Mitochondria and Fungal Pathogenesis: Drug Tolerance, Virulence, and Potential for Antifungal Therapy

Shingu-Vazquez, Miguel, Traven, Ana·2011·Eukaryotic Cell

Cited by (210)

Items 101–200 of 210

  1. Genome-Wide Response to Drugs and Stress in the Pathogenic Yeast Candida glabrata
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  2. Diversity of Mobile Genetic Elements in the Mitogenomes of Closely Related Fusarium culmorum and F. graminearum sensu stricto Strains and Its Implication for Diagnostic Purposes
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  3. Mechanistic Insights into the Anticandidal Action of Vanillin Reveal Disruption of Cell Surface Integrity and Mitochondrial Functioning
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  4. Responses of the Necrotrophic Fungus Alternaria brassisicola to the Indolic Phytoalexin Brassinin
    Guillaume Quang Henri Nguyen, Roxane Raulo, Antoine Porquier, Beatrice Iacomı, Sandra Pelletier, Jean‐Pierre Renou, Nelly Bataillé‐Simoneau, Claire Campion, Bruno Hamon, Anthony Kwasiborski et al. · 2021 · Frontiers in Plant Science
  5. Identification and Characterization of Key Charged Residues in the Cofilin Protein Involved in Azole Susceptibility, Apoptosis, and Virulence of Aspergillus fumigatus
    Zhongyi Lu, Xiaodong Jia, Yong Chen, Xuelin Han, Fangyan Chen, Shuguang Tian, Xueting Su, Zongwei Li, Jingya Zhao, Xi Zhang et al. · 2018 · Antimicrobial Agents and Chemotherapy
  6. Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin
    Theresia Conrad, Olaf Kniemeyer, Sebastian Henkel, Thomas Krüger, Derek J. Mattern, Vito Valiante, Reinhard Guthke, Ilse Denise Jacobsen, Axel A. Brakhage, S. Vlaic et al. · 2018 · BMC Systems Biology
  7. Proteomics Analysis of Candida albicans dnm1 Haploid Mutant Unraveled the Association between Mitochondrial Fission and Antifungal Susceptibility
    Thuyen Truong, Guisheng Zeng, Teck Kwang Lim, Tong Cao, Li Mei Pang, Yew Mun Lee, Qingsong Lin, Yue Wang, Chaminda Jayampath Seneviratne · 2019 · PROTEOMICS
  8. Mitochondrial Genome Sequences of the Emerging Fungal Pathogen Candida auris
    Elizabeth Misas, Nancy A. Chow, Oscar Mauricio Gómez, José F. Muñoz, Juan Guillermo McEwen, Anastasia P. Litvintseva, Oliver Clay · 2020 · Frontiers in Microbiology
  9. Functional Analyses of the Bacillus velezensis HMB26553 Genome Provide Evidence That Its Genes Are Potentially Related to the Promotion of Plant Growth and Prevention of Cotton Rhizoctonia Damping-Off
    Zhenhe Su, Gaoge Liu, Xiaomeng Liu, Shezeng Li, Xiuyun Lu, Peipei Wang, Weisong Zhao, Xiaoyun Zhang, Lihong Dong, Yuanhang Qu et al. · 2023 · Cells
  10. Combined Transcriptome and Metabolome Analysis Reveals That the Potent Antifungal Pyrylium Salt Inhibits Mitochondrial Complex I in Candida albicans
    Lv, Quanzhen, Yan, Lan, Wang, Jinxin, Feng, Jia, Gao, Lu, Qiu, Lijuan, Chao, Wen, Qin, Yu-Lin, Jiang, Yuanying · 2023 · Microbiology Spectrum
  11. The mitochondrial protein Bcs1A regulates antifungal drug tolerance by affecting efflux pump expression in the filamentous pathogenic fungus Aspergillus fumigatus
    Guorong Yang, Weiwei Shi, Wenlin He, Jing Wu, Sutao Huang, Mo Li, Junjie Zhang, Huaxue Wang, Xiaogang Zhou · 2024 · Microbiology Spectrum
  12. Deciphering the role of mitochondria in human fungal drug resistance
    Yuanyuan Ma, Yachun Zhou, Tianyuan Jia, Zilin Zhuang, Peng Xue, Liang Yang · 2025 · Mycology: An International Journal on Fungal Biology
  13. Low Glucose Mediated Fluconazole Tolerance in Cryptococcus neoformans
    Somanon Bhattacharya, Natália Kronbauer Oliveira, Anne G. Savitt, Vanessa K. A. Silva, Rachel B. Krausert, Berhane Ghebrehiwet, Bettina C. Fries · 2021 · Journal of Fungi
  14. Dysfunction of Prohibitin 2 Results in Reduced Susceptibility to Multiple Antifungal Drugs via Activation of the Oxidative Stress-Responsive Transcription Factor Pap1 in Fission Yeast
    Qiannan Liu, Fan Yao, Guanglie Jiang, Min Xu, Si Chen, Lina Zhou, Norihiro Sakamoto, Takayoshi Kuno, Yue Fang · 2018 · Antimicrobial Agents and Chemotherapy
  15. Mechanisms of Drug Resistance in Fungi and Their Significance in Biofilms
    Rajendra Prasad, Abdul Haseeb Shah, Sanjiveeni Dhamgaye · 2014 · Springer series on biofilms
  16. Phospholipid biosynthesis disruption renders the yeast cells sensitive to antifungals
    Deepika Kundu, Saif Hameed, Zeeshan Fatima, Ritu Pasrija · 2019 · Folia Microbiologica
  17. Down-regulation of TUFM impairs host cell interaction and virulence by Paracoccidioides brasiliensis
    Caroline Maria Marcos, Gabrielle Tamer, Haroldo César de Oliveira, Patrícia Akemi Assato, Liliana Scorzoni, Cláudia Tavares dos Santos, Júnya de Lacorte Singulani, Julhiany de Fátima da Silva, Rodrigo de Almeida, Ana Carolina Alves de Paula e Silva et al. · 2019 · Scientific Reports
  18. Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism.
    Xibo Zhang, Yue Fang, Wurentuya Jaiseng, Lingling Hu, Yabin Lü, Yan Ma, Tomoyuki Furuyashiki · 2015 · PubMed
  19. Anticandidal Agent for Multiple Targets: The Next Paradigm in the Discovery of Proficient Therapeutics/Overcoming Drug Resistance
    Anubhuti Jha, Awanish Kumar · 2019 · Future Medicinal Chemistry
  20. Requirement of a putative mitochondrial GTPase, GemA, for azole susceptibility, virulence, and cell wall integrity in Aspergillus fumigatus
    Zhou, Xiaogang, Yang, Guorong, Li, Chengxi, Yang, Fan, Chang, Xuelian · 2022 · Frontiers in Microbiology
  21. Azorean Black Tea (Camellia sinensis) Antidermatophytic and Fungicidal Properties
    Chantal Fernandes, José Sousa-Baptista, Ana Filipa Lenha-Silva, Daniela Calheiros, Edmilson Emanuel Monteiro Correia, Artur Figueirinha, Lı́gia Salgueiro, Teresa Gonçalves · 2023 · Molecules
  22. Repurposing of MitoTam: Novel Anti-Cancer Drug Candidate Exhibits Potent Activity against Major Protozoan and Fungal Pathogens
    Dominik Arbon, Kateřina Ženíšková, Karolína Šubrtová, Jan Mach, Jan Štursa, Marta Machado, Farnaz Zahedifard, Tereza Leštinová, Carolina Hierro-Yap, Jiřı́ Neužil et al. · 2022 · Antimicrobial Agents and Chemotherapy
  23. Codon usage bias analysis of mitochondrial protein-coding genes in 12 species of Candida
    Fen Wang, Nan Zhang, Chunling Zhao, Zhangyong Song, Caiyan Xin · 2023 · Journal of Genetics
  24. Arf-like proteins (Arl1 and Arl2) are involved in mitochondrial homeostasis in Mucor circinelloides
    José Alberto Patiño-Medina, Marco Iván Valle-Maldonado, David Vargas-Tejeda, Víctor M. Chávez-Jacobo, Alma Rosa Corrales Escobosa, Joel Ramı́rez-Emiliano, León Francisco Ruíz‐Herrera, Martha Isela Ramírez-Díaz, Victoriano Garre, Víctor Meza‐Carmen · 2020 · Fungal Biology
  25. Stable Redox-Cycling Nitroxide Tempol Has Antifungal and Immune-Modulatory Properties
    Ava Hosseinzadeh, Marios Stylianou, José Pedro Lopes, Daniel C. Müller, André Häggman, Sandra M. Holmberg, Christian Grumaz, Anders F. Johansson, Kai Sohn, Christoph Dieterich et al. · 2019 · Frontiers in Microbiology
  26. Exposure of Candida parapsilosis to the silver(I) compound SBC3 induces alterations in the proteome and reduced virulence
    Magdalena E. Piatek, Cillian O’Beirne, Zoe Beato, Matthias Tacke, Kevin A. Kavanagh · 2022 · Metallomics
  27. Known Antimicrobials Versus Nortriptyline in Candida albicans: Repositioning an Old Drug for New Targets
    Caldara, Marina, Marmiroli, Nelson · 2020 · Microorganisms
  28. Edeine B 1 produced by Brevibacillus brevis reduces the virulence of a plant pathogenic fungus by inhibiting mitochondrial respiration
    Bomin Kim, Minh Van Nguyen, Jiyeun Park, Yeong Seok Kim, Jae Woo Han, Joo-Youn Lee, Junhyun Jeon, Hokyoung Son, Gyung Ja Choi, Hun Kim · 2024 · mBio
  29. Clotrimazole disrupts ergosterol biosynthesis and cell membrane integrity via targeting sterol 14α-demethylases to suppress virulence of Magnaporthe oryzae
    Jing Wang, Lizi Zuo, Ziqi Lu, Muhammad Noman, Chenwen Xiao, Haiping Qiu, Zhongna Hao, Yingying Cai, Zhen Zhang, Rongyao Chai et al. · 2025 · International Journal of Biological Macromolecules
  30. Atypical changes in Candida albicans cells treated with the Venetin-1 complex from earthworm coelomic fluid
    Sylwia Wójcik-Mieszawska, Kinga Lewtak, Weronika Sofińska-Chmiel, Jerzy Wydrych, Marta J. Fiołka · 2023 · Scientific Reports
  31. Transcriptome analysis and Structure-Based drug discovery identifies potential biofungicides for controlling Fusarium wilt in chickpea
    Rosaleen Sahoo, Narendra Y. Kadoo · 2024 · Journal of Molecular Liquids
  32. Fungicide Xylaria sp. BCC 1067 Extract Induces Reactive Oxygen Species and Activates Multidrug Resistance System in Saccharomyces Cerevisiae
    Pichayada Somboon, Attaporn Poonsawad, Songsak Wattanachaisaereekul, Laran T. Jensen, Masakazu Niimi, Supapon Cheevadhanarak, Nitnipa Soontorngun · 2017 · Future Microbiology
  33. Uncovering the role of mitochondrial genome in pathogenicity and drug resistance in pathogenic fungi
    Yue Ni, Xindi Gao · 2025 · Frontiers in Cellular and Infection Microbiology
  34. Candida auris vacuolar calcium pump mediates fluconazole efflux and resistance evolution
    Yabing Song, Jinxin Chen, Junhua Wan, Jiamo Zhang, Qizheng Liu, Fei Sun, Hanlin Zhang, Yuru Guo, Eve W. L. Chow, Yali Chen et al. · 2026 · Nature Microbiology
  35. Blocking the shikimate pathway amplifies the impact of carvacrol on biofilm formation in Candida albicans
    Ali Molaeitabari, Tanya E. S. Dahms · 2025 · Microbiology Spectrum
  36. The sat1 Gene Is Required for the Growth and Virulence of the Human Pathogenic Fungus Aspergillus fumigatus
    Yunyun Wei, Dan He, Busi Zhao, Yuhuan Liu, Song Gao, Xiaowei Zhang, Li Wang · 2022 · Microbiology Spectrum
  37. Purification and characterization of a cytochrome c with novel caspase-3 activation activity from the pathogenic fungus Rhizopus arrhizus
    Manoj Saxena, Rohit Kumar Sharma, Josell Ramírez‐Paz, Arthur D. Tinoco, Kai H. Griebenow · 2015 · BMC Biochemistry
  38. Sequence modification of the master regulator Pdr1 interferes with its transcriptional autoregulation and confers altered azole resistance in Candida glabrata
    Yuan Tian, Ning Gao, Qi Ni, Yinhe Mao, Danfeng Dong, Xinhua Huang, Cen Jiang, Zhen Li, Lihua Zhang, Xuefeng Wang et al. · 2018 · FEMS Yeast Research
  39. The antifungal activities and biological consequences of BMVC-12C-P, a carbazole derivative against Candida species
    Mandy Shen, Pei‐Tzu Li, Yan-Jia Wu, Ching‐Hsuan Lin, Eric Chai, Ta‐Chau Chang, Chin‐Tin Chen · 2019 · Medical Mycology
  40. The First Mitochondrial Genome of Ciborinia camelliae and Its Position in the Sclerotiniaceae Family
    Irene Valenti, Luca Degradi, Andrea Kunova, P. Cortesi, Matias Pasquali, M. Saracchi · 2022 · Frontiers in Fungal Biology
  41. Whole-Genome Approach to Understanding the Mechanism of Action of a Histatin 5-Derived Peptide
    Cody B. Bullock, David S. McNabb, Inés Pinto · 2019 · Antimicrobial Agents and Chemotherapy
  42. Mitochondrial Protease Oct1p Regulates Mitochondrial Homeostasis and Influences Pathogenicity through Affecting Hyphal Growth and Biofilm Formation Activities in Candida albicans
    Zhu, Xiaoxiao, Jin, Feng, Yang, Guangyuan, Zhuang, Tian, Zhang, Cangcang, Zhou, Hanjing, Niu, Xiaojia, Wang, Hongchen, Wu, Daqiang · 2024 · Journal of Fungi
  43. The Dual Role of Mitochondria in Infection: Sentinels of Immunity and Targets of Pathogen Manipulation
    Rim Abbas, Ghassan Ghssein · 2025 · Clinical bioenergetics
  44. GSNOR plays roles in growth, pathogenicity, and stress resistance by modulating mitochondrial protein COX6B S-nitrosylation in Colletotrichum gloeosporioides
    Xing Ya Yang, Yongbao Yang, Aoxue Wang, Zhihao Zhao, Hongli Luo, Bang An, Qiannan Wang · 2025 · mBio
  45. Host species and pathogenicity effects in the evolution of the mitochondrial genomes of Eimeria species (Apicomplexa; Coccidia; Eimeriidae)
    Asma Awadi · 2017 · Journal of Biological Research - Thessaloniki
  46. A Novel Use for an Old Drug: Resistance Reversal in Candida Albicans by Combining Dihydroartemisinin with Fluconazole
    Hui Li, Hai‐Sheng Chen, Wenna Shi, Jing Shi, Jupeng Yuan, Cunxian Duan, Qing Fan, Yuguo Liu · 2021 · Future Microbiology
  47. Deletion of the Candida albicans TLO gene family results in alterations in membrane sterol composition and fluconazole tolerance
    James O’Connor-Moneley, Jessica Fletcher, Cody Bean, Josie E. Parker, Steven L. Kelly, Gary P. Moran, Derek J. Sullivan · 2024 · PLoS ONE
  48. Mitochondrial Protein Nfu1 Influences Homeostasis of Essential Metals in the Human Fungal Pathogen Cryptococcus neoformans
    Jeongmi Kim, Minji Park, Eunsoo Do, Won Hee Jung · 2014 · Mycobiology
  49. Mass spectrometry‐based untargeted lipidomics reveals new compositional insights into membrane dynamics of Candida albicans under magnesium deprivation
    Sandeep Hans, Zeeshan Fatima, Saif Hameed · 2021 · Journal of Applied Microbiology
  50. Mitochondrial anchor protein Num11 is key to pathogenicity of Candida albicans by affecting mitochondrial function and cell wall masking
    Yang, Guangyuan, Niu, Xiaojia, Zhuang, Tian, Zhu, Xiaoxiao, Xu, Qianwen, Wang, Hongchen, Shao, Jing, Wang, Changzhong, Yang, Yue, Wang, Tianming et al. · 2025 · Virulence
  51. Agricultural SDHIs Induce Azole Resistance in Aspergillus fumigatus via Mitochondrial Sdh1 Suppression
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  52. Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance
    Andreas Fellas, Alison L Pidoux, Pin Tong, Harriet H Hewes, Emma C. Wallace, Robin C. Allshire · 2025 · The EMBO Journal
  53. Only One of Three Bcs1 Homologs in Aspergillus fumigatus Confers Respiratory Growth
    Isabel Klugherz, Marion Basch, Natanya Ng, Zhaojun Zhu, Nikola Wagener, Johannes Wagener · 2023 · Journal of Fungi
  54. Uncovering the antifungal potential of Cannabidiol and Cannabidivarin
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  55. Fungal mitochondria govern both gliotoxin biosynthesis and self-protection
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  56. Novel Azole-Modified Porphyrins for Mitochondria-Targeted Photodynamic Therapy
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  57. Mitochondria in Cryptococcus: an update of mitochondrial transcriptional regulation in Cryptococcus
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  58. Sterol‐Targeted Laboratory Evolution Allows the Isolation of Thermotolerant and Respiratory‐Competent Clones of the Industrial Yeast Saccharomyces cerevisiae
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  59. ER–mitochondria encounter structure connections determine drug sensitivity and virulence of Cryptococcus neoformans
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  60. Synthesis, biological evaluation and docking study of possible antifungal compounds with a coumarin-containing triazole side chain
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  61. Genetic landscape of an in vivo protein interactome
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  62. Boronic acid derivatives inhibit Candida albicans growth by compromising energy metabolism
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  63. Antifungal activity of cinnamaldehyde against Aspergillus fumigatus involves disruption of the TCA cycle and protein metabolism
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  64. A comprehensive review of Candida spp./bacteria interactions within polymicrobial biofilms: resistance and therapeutic strategies
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  65. Multidrug Resistance in Fusarium incarnatum from Maize Stalk Rot: Molecular Mechanisms and Fitness Characterization
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  69. Thonzonium bromide inhibits progression of malignant pleural mesothelioma through regulation of ERK1/2 and p38 pathways and mitochondrial uncoupling
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  70. Is metabolic generalism the Breakfast of Champions for pathogenic Candida species?
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  74. Human Fungal Pathogens and Drug Resistance Against Azole Drugs
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  75. Multiple rearrangements and low inter- and intra-species mitogenome sequence variation in the Heterobasidion annosum s.l. species complex
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  76. Mss2 shapes the virulence of Candida albicans through reactive oxygen species (ROS) and calcium signaling, independent of direct transcriptional control
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  77. Current scenario of antifungal resistance and the drugs in the pipeline
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  82. Heterologous expression of mitochondrial nicotinamide adenine dinucleotide transporter (Ndt1) from Aspergillus fumigatus rescues impaired growth in Δndt1Δndt2 Saccharomyces cerevisiae strain
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  83. In the Crossroad Between Drug Resistance and Virulence in Fungal Pathogens
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  84. Mitochondrial cardiolipin sequestration of caspofungin underlies Cryptococcus neoformans inherent resistance and may contribute to cardiotoxicity
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  85. Análise dos níveis relativos de transcrição de genes antioxidantes e da cadeia de transporte de elétrons de Aspergillus fumigatus
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  86. Assessing Mitochondrial Functions in Candida albicans
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  87. Systems in Candida albicans Mitochondrial Two-Component Signaling
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  88. Caracterização molecular e bioquímica de um transportador mitocondrial de nicotinamida adenina dinucleotídeo de Aspergillus fumigatus
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  89. Hijacking the Candida albicans Multidrug Resistant Transporter MDR1 to Potentiate Antifungal Activity
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  90. Role of Mitochondria in Fungal Drug Resistance
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  91. The structural organization and functions of the ERMES complex in fungi
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  93. Assessing Complex I (CI) Mitochondrial Subunit Protein Functions in Candida albicans
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  94. Kemampuan Ekstrak Etanol Batang Brotowali (Tinospora crispa L.) Sebagai Antifungi Terhadap Candida tropicalis
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  95. Succinate Dehydrogenase Inhibitors as Triggers of Azole Resistance in Aspergillus fumigatus: The Role of sdh1 and Efflux Pathways
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  97. Recent Advances on Resistance Mechanism and Structural Modification of Azole Drugs
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  98. Additional file 1 of Thonzonium bromide inhibits progression of malignant pleural mesothelioma through regulation of ERK1/2 and p38 pathways and mitochondrial uncoupling
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  99. Additional file 2 of Thonzonium bromide inhibits progression of malignant pleural mesothelioma through regulation of ERK1/2 and p38 pathways and mitochondrial uncoupling
    Irene Dell’Anno, Federica Morani, Simone Patergnani, Antonio Daga, Pinton, Paolo, Carlotta Giorgi, Luciano Mutti, Federica Gemignani, Stefano Landi · 2024 · Figshare
  100. Efficient star polycation-based thifluzamide for destructive soil-borne disease: High direct fungicidal activity via impairing citrate cycle and amino acid metabolism
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