Cited by 308Fungal and yeast genetics researchRedox biology and oxidative stressAntifungal resistance and susceptibility

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The Hog1 Mitogen-Activated Protein Kinase Is Essential in the Oxidative Stress Response and Chlamydospore Formation in Candidaalbicans

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Alonso-Monge, Rebeca, Navarro-García, Federico, Román, Elvira, Negredo, Ana I., Eisman, Blanca, Nombela, César, Pla, Jesús·2003·Eukaryotic Cell

DOI 10.1128/ec.2.2.351-361.2003PMC PMC154845

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Abstract

Candidaalbicans mutants with mutations in mitogen-activated protein (MAP) kinase HOG1 displayed an increased sensitivity to agents producing reactive oxygen species, such as oxidants (menadione, hydrogen peroxide, or potassium superoxide), and UV light. Consistent with this finding,C.albicans Hog1 was activated not only in response to an increase in external osmolarity, as happens with its Saccharomycescerevisiae homologue, but also in response to hydrogen peroxide. The Hog1-mediated response to oxidative stress was different from that of transcription factor Cap1, the homologue of S.cerevisiae Yap1, as shown by the different sensitivities to oxidants and the kinetics of cell death of cap1 Δ,hog1, and hog1cap1 Δ mutants. Deletion of CAP1 did not influence the level of Hog1 phosphorylation, and deletion of HOG1 did not affect Cap1 nuclear localization. Moreover, we show that the HOG1 gene plays a role in chlamydospore formation, another oxygen-related morphogenetic event, as demonstrated by the fact that hog1 cells were unable to generate these thick-walled structures in several media through a mechanism different from that of the EFG1 regulator. This is the first demonstration of the role of the Hog1-mediated MAP kinase pathway in resistance to oxidative stress in pathogenic fungi, and it allows us to propose a molecular model for the oxidative stress response in C.albicans.

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Authors: Alonso-Monge, R., Navarro-García, F., Román, E., Negredo, A. I., Eisman, B., Nombela, C., & Pla, J.
Affiliations: Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, E-28040 Madrid, Spain
Universidad Complutense de Madrid (ES)
Venue: Eukaryotic Cell
Publisher: American Society for Microbiology
Published: 2003-04
Volume: 2
Issue: 2
Pages: 351-361
ISSN: 1535-9778 (ISSN-L)
1535-9786
DOI: 10.1128/ec.2.2.351-361.2003
PMC: PMC154845
OpenAlex: W2146807721
Cited by: 308
References: 73
Citations by year: 2026: 8 · 2025: 13 · 2024: 10 · 2023: 8 · 2022: 7 · 2021: 9 · 2020: 12 · 2019: 10 · 2018: 15 · 2017: 22 · 2016: 15 · 2015: 11 · 2014: 18 · 2013: 12 · 2012: 11
FWCI: 6.56
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Eukaryotic Cell (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Ministerio de Ciencia y Tecnología
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords: Hog1 MAP kinase, Candida albicans, oxidative stress response, chlamydospore formation, hydrogen peroxide, reactive oxygen species, EFG1, fungal pathogenicity, cell death
MeSH terms: Candida albicans, Cell Nucleus, Cells, Cultured, Fungal Proteins, Mutation, Osmolar Concentration, Phosphorylation, Spores, Fungal, Ultraviolet Rays, Organelles, Oxidants, Cell Death, Reactive Oxygen Species, Oxidative Stress, Cell Cycle Proteins, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, Saccharomyces cerevisiae Proteins, Basic-Leucine Zipper Transcription Factors

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The Hog1 Mitogen-Activated Protein Kinase Is Essential in the Oxidative Stress Response and Chlamydospore Formation in Candidaalbicans

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