The Hog1 MAP kinase controls respiratory metabolism in the fungal pathogen Candida albicans

Alonso-Monge, Rebeca; Carvaihlo, Sara; Nombela, Cesar; Rial, Eduardo; Pla, Jesús

doi:10.1099/mic.0.023309-0

Cited by 105Fungal and yeast genetics researchMitochondrial Function and PathologyAntifungal resistance and susceptibility

The Hog1 MAP kinase controls respiratory metabolism in the fungal pathogen Candida albicans

Alonso-Monge, Rebeca, Carvaihlo, Sara, Nombela, Cesar, Rial, Eduardo, Pla, Jesús·2009·Microbiology

DOI 10.1099/mic.0.023309-0

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Abstract

Signal transduction pathways mediated by mitogen-activated protein kinases (MAPKs) play crucial roles in eukaryotic cells. In the pathogenic fungus Candida albicans the HOG MAPK pathway regulates the response to external stresses (osmotic and oxidative among others) and is involved in morphogenesis and virulence. We show here that the lack of the Hog1 MAPK increases the sensitivity of this fungus to inhibitors of the respiratory chain.hog1 mutants also show an enhanced basal respiratory rate compared to parental strains, and higher levels of intracellular reactive oxygen species despite an increased expression of detoxifying enzymes. We also demonstrate that although oxidative phosphorylation is essentially unaffected,hog1 mutants have an altered mitochondrial membrane potential. Data indicate that hog1-defective mutants are more dependent on mitochondrial ATP synthesis, probably due to an increased cellular ATP demand. Our results therefore link a MAPK pathway with respiratory metabolism in pathogenic fungi.

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In C. albicans, both the alternative oxidase (CaAox2) and thioredoxin (CaTrx1) are directly involved in the response to oxidative stress.
“In C. albicans, both, the alternative oxidase (CaAox2) and thioredoxin (CaTrx1), are directly involved in the response to oxidative stress”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Alonso-Monge et al. 2009
The Hog1 MAP kinase integrating osmolarity homeostasis with respiratory metabolism and retrograde signaling is an example of such conserved mechanism present both in S. cerevisiae and C. albicans.
“The Hog1 MAP kinase integrating osmolarity homeostasis with respiratory metabolism and retrograde signaling is an example of such conserved mechanism that is present both in S. cerevisiae (Guaragnella et al. 2013, 2021, Di Noia et al. 2023, 2024) and C. albicans (Alonso-Monge et al. 2009).”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Alonso-Monge et al. 2009
Modulation of stress response, in particular to osmotic stress, depending on respiratory capacity is observed in S. cerevisiae and C. albicans.
“Modulation of stress response, in particular to the osmotic stress, depending on respiratory capacity is observed in S. cerevisiae (Di Noia et al. 2023, 2024) as well as in C. albicans (Alonso-Monge et al. 2009).”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Alonso-Monge et al. 2009
In C. albicans, Hog1 MAPK is a major regulator of fungal stress response, morphogenesis, and virulence.
“In C. albicans, Hog1 MAPK is a major regulator of fungal stress response, morphogenesis, and virulence (32–34, 36, 61).”
From The Candida auris Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence (2024) · cites this paper as [61]

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The MAPK Hog1 mediates the response to amphotericin B in Candida albicans
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Authors: Alonso-Monge, R., Carvaihlo, S., Nombela, C., Rial, E., & Pla, J.
Affiliations: Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, E-28040 Madrid, Spain
Universidad Complutense de Madrid (ES)
Consejo Superior de Investigaciones Científicas (ES)
ORCID: Rial, Eduardo
Venue: Microbiology
Publisher: Microbiology Society
Published: 2009-02-01
Volume: 155
Issue: 2
Pages: 413-423
ISSN: 1350-0872 (ISSN-L)
1465-2080
DOI: 10.1099/mic.0.023309-0
OpenAlex: W2154125232
Semantic Scholar: e401aa71188c912af62a67fe67f6580e7cde61d3
Cited by: 105
References: 40
Citations by year: 2026: 3 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 8 · 2018: 6 · 2017: 15 · 2016: 7 · 2015: 3 · 2014: 8 · 2013: 7 · 2012: 7
FWCI: 2.68
Type: journal article
Language: en
Open access: closed
Locations: Microbiology (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders: Universidad Complutense de Madrid
Ministerio de Ciencia y Tecnología
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords: Hog1 MAP kinase, Candida albicans, respiratory metabolism, respiratory chain inhibitors, oxidative phosphorylation, reactive oxygen species, mitochondrial membrane potential, mitochondrial ATP production, osmotic stress response, oxidative stress response, fungal pathogenesis
MeSH terms: Adenosine Triphosphate, Candida albicans, Candidiasis, Chloramphenicol, Electron Transport, Fungal Proteins, Mitochondria, Mutation, Oligomycins, Oxygen, Oxidative Stress, Mitogen-Activated Protein Kinases, Membrane Potential, Mitochondrial

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The Hog1 MAP kinase controls respiratory metabolism in the fungal pathogen Candida albicans

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