Cited by 208Gut microbiota and healthT-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

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Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia

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Gauguet, Stefanie, D'Ortona, Samantha, Ahnger-Pier, Kathryn, Duan, Biyan, Surana, Neeraj K., Lu, Roger, Cywes-Bentley, Colette, Gadjeva, Mihaela, Shan, Qiang, Priebe, Gregory P., Pier, Gerald B.·2015·Infection and Immunity

DOI 10.1128/iai.00037-15PMC PMC4567647

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Abstract

Th17 immunity in the gastrointestinal tract is regulated by the intestinal microbiota composition, particularly the presence of segmented filamentous bacteria (sfb), but the role of the intestinal microbiota in pulmonary host defense is not well explored. We tested whether altering the gut microbiota by acquiring sfb influences the susceptibility to staphylococcal pneumonia via induction of type 17 immunity. Groups of C57BL/6 mice which differed in their intestinal colonization with sfb were challenged with methicillin-resistant Staphylococcus aureus in an acute lung infection model. Bacterial burdens, bronchoalveolar lavage fluid (BALF) cell counts, cell types, and cytokine levels were compared between mice from different vendors, mice from both vendors after cohousing, mice given sfb orally prior to infection, and mice with and without exogenous interleukin-22 (IL-22) or anti-IL-22 antibodies. Mice lacking sfb developed more severe S. aureus pneumonia than mice colonized with sfb, as indicated by higher bacterial burdens in the lungs, lung inflammation, and mortality. This difference was reduced when sfb-negative mice acquired sfb in their gut microbiota through cohousing with sfb-positive mice or when given sfb orally. Levels of type 17 immune effectors in the lung were higher after infection in sfb-positive mice and increased in sfb-negative mice after acquisition of sfb, as demonstrated by higher levels of IL-22 and larger numbers of IL-22(+) TCRβ(+) cells and neutrophil…

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Authors: Gauguet, S., D'Ortona, S., Ahnger-Pier, K., Duan, B., Surana, N. K., Lu, R., Cywes-Bentley, C., Gadjeva, M., Shan, Q., Priebe, G. P., & Pier, G. B.
Affiliations: Brigham and Women's Hospital (US)
Boston Children's Hospital (US)
Division of Infectious Diseases, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
ORCID: Gauguet, Stefanie
Ahnger-Pier, Kathryn
Surana, Neeraj K.
Gadjeva, Mihaela
Shan, Qiang
Priebe, Gregory P.
Pier, Gerald B.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2015-10
Volume: 83
Issue: 10
Pages: 4003-4014
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.00037-15
PMC: PMC4567647
OpenAlex: W1789863752
Cited by: 208
References: 48
Citations by year: 2026: 11 · 2025: 13 · 2024: 18 · 2023: 19 · 2022: 23 · 2021: 18 · 2020: 26 · 2019: 20 · 2018: 19 · 2017: 18 · 2016: 22 · 2015: 1
FWCI: 8.69
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL092515)
National Eye Institute (R01EY022054)
National Institute of Allergy and Infectious Diseases (K08AI108690, AI057159, R21AI046706, U54AI057159, R01AI046706, AI 46706)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD047349)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: gut microbiota, segmented filamentous bacteria, Staphylococcus aureus pneumonia, methicillin-resistant Staphylococcus aureus, Th17 response, IL-22, pulmonary host defense, lung inflammation, bacterial translocation, cohousing, neutrophils
MeSH terms: Gastrointestinal Microbiome, Interleukin-22, Animals, Female, Humans, Interleukins, Intestines, Lung, Male, Mice, Inbred C57BL, Pneumonia, Staphylococcal, Staphylococcus aureus, Mice

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Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia

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