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Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia
Open accessAbstract
Th17 immunity in the gastrointestinal tract is regulated by the intestinal microbiota composition, particularly the presence of segmented filamentous bacteria (sfb), but the role of the intestinal microbiota in pulmonary host defense is not well explored. We tested whether altering the gut microbiota by acquiring sfb influences the susceptibility to staphylococcal pneumonia via induction of type 17 immunity. Groups of C57BL/6 mice which differed in their intestinal colonization with sfb were challenged with methicillin-resistant Staphylococcus aureus in an acute lung infection model. Bacterial burdens, bronchoalveolar lavage fluid (BALF) cell counts, cell types, and cytokine levels were compared between mice from different vendors, mice from both vendors after cohousing, mice given sfb orally prior to infection, and mice with and without exogenous interleukin-22 (IL-22) or anti-IL-22 antibodies. Mice lacking sfb developed more severe S. aureus pneumonia than mice colonized with sfb, as indicated by higher bacterial burdens in the lungs, lung inflammation, and mortality. This difference was reduced when sfb-negative mice acquired sfb in their gut microbiota through cohousing with sfb-positive mice or when given sfb orally. Levels of type 17 immune effectors in the lung were higher after infection in sfb-positive mice and increased in sfb-negative mice after acquisition of sfb, as demonstrated by higher levels of IL-22 and larger numbers of IL-22(+) TCRβ(+) cells and neutrophil…
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“SFB-deficient animals have increased lung bacterial burdens and more severe pneumonia when challenged with methicillin-resistant Staphylococcus aureus (MRSA) (54), which was associated with decreased IL-17-mediated responses in the lung.”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [54]
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Metadata
- Authors
- Gauguet, S., D'Ortona, S., Ahnger-Pier, K., Duan, B., Surana, N. K., Lu, R., Cywes-Bentley, C., Gadjeva, M., Shan, Q., Priebe, G. P., & Pier, G. B.
- Affiliations
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Division of Infectious Diseases, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
- ORCID
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2015-10
- Volume
- 83
- Issue
- 10
- Pages
- 4003-4014
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC4567647
- OpenAlex
- W1789863752
- Cited by
- 208
- References
- 48
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 18 · 2023: 19 · 2022: 23 · 2021: 18 · 2020: 26 · 2019: 20 · 2018: 19 · 2017: 18 · 2016: 22 · 2015: 1
- FWCI
- 8.69
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Infection and Immunity (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL092515)
- National Eye Institute (R01EY022054)
- National Institute of Allergy and Infectious Diseases (K08AI108690, AI057159, R21AI046706, U54AI057159, R01AI046706, AI 46706)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD047349)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- gut microbiota, segmented filamentous bacteria, Staphylococcus aureus pneumonia, methicillin-resistant Staphylococcus aureus, Th17 response, IL-22, pulmonary host defense, lung inflammation, bacterial translocation, cohousing, neutrophils
- MeSH terms
- Gastrointestinal Microbiome, Interleukin-22, Animals, Female, Humans, Interleukins, Intestines, Lung, Male, Mice, Inbred C57BL, Pneumonia, Staphylococcal, Staphylococcus aureus, Mice
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