Characterization of Global Gene Expression, Regulation of Metal Ions, and Infection Outcomes in Immune-Competent 129S6 Mouse Macrophages
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Abstract
Nutritional immunity involves cellular and physiological responses to invading pathogens, such as limiting iron, increasing exposure to bactericidal copper, and altering zinc to restrict the growth of pathogens. Here, we examine infection of bone marrow-derived macrophages from 129S6/SvEvTac mice by Salmonella enterica serovar Typhimurium.
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Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
Iron in infection and immunity
Cassat, J. E., & Skaar, E. P. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.04.010 · Cited by 1,214 · see citing works
A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity
White, C., Lee, J., Kambe, T., Fritsche, K., & Petris, M. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.070201 · Cited by 524 · see citing works
Lipocalin 2: an emerging player in iron homeostasis and inflammation
Xiao, X., Yeoh, B. S., & Vijay-Kumar, M. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064559 · Cited by 426 · see citing works
Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human Macrophages
Botella, H., Peyron, P., Levillain, F., Poincloux, R., Poquet, Y., Brandli, I., Wang, C., Tailleux, L., Tilleul, S., Charrière, G. M., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.08.006 · Cited by 381 · see citing works
ZIP8 Regulates Host Defense through Zinc-Mediated Inhibition of NF-κB
Liu, M.-J., Bao, S., Gálvez-Peralta, M., Pyle, C. J., Rudawsky, A. C., Pavlovicz, R. E., Killilea, D. W., Li, C., Nebert, D. W., Wewers, M. D., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.009 · Cited by 367 · see citing works
Ganz, T. (2018) · International Journal of Hematology · doi:10.1007/s12185-017-2366-2 · Cited by 270 · see citing works
A bioinformatics view of zinc enzymes
Andreini, C., & Bertini, I. (2012) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2011.11.020 · Cited by 227 · cited 1× · see citing works
“In mammals, Zn is a requisite cofactor for approximately 10% of the proteome (8), including many transcription factors and enzymes.”
BackgroundNúñez, G., Sakamoto, K., & Soares, M. P. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800325 · Cited by 115 · see citing works
Iron Regulatory Proteins Mediate Host Resistance to Salmonella Infection
Nairz, M., Ferring-Appel, D., Casarrubea, D., Sonnweber, T., Viatte, L., Schroll, A., Haschka, D., Fang, F. C., Hentze, M. W., Weiss, G., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.06.017 · Cited by 103 · see citing works
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- Authors
- Janiszewski, L. N., Minson, M., Allen, M. A., Dowell, R. D., & Palmer, A. E.
- Affiliations
- University of Colorado Boulder (US)
- Corresponding author
- Palmer, Amy E.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2021-10-15
- Volume
- 89
- Issue
- 11
- Pages
- e0027321-e0027321
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC8519282
- OpenAlex
- W3192348233
- Cited by
- 6
- References
- 10
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 1
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Infection and Immunity (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CU Scholar (University of Colorado Boulder) (submittedVersion)
- Funders
- HHS | National Institutes of Health (DP1 GM114863, R35 GM139644, R01 GM125871, R01 HL156475)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Keywords
- nutritional immunity, Salmonella typhimurium, macrophages, SLC11A1, zinc homeostasis, iron limitation, copper, host-pathogen interaction, bacterial clearance, transcriptome, mouse strain differences
- MeSH terms
- Animals, Complement System Proteins, Female, Macrophages, Metals, Mice, Inbred C57BL, Salmonella Infections, Animal, Salmonella typhimurium, Zinc, Gene Expression, Mice, Host-Pathogen Interactions
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