The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Polyclonal Mucosa-Associated Invariant T Cells Have Unique Innate Functions in Bacterial Infection
Open accessAbstract
Mucosa-associated invariant T (MAIT) cells are a unique population of αβ T cells in mammals that reside preferentially in mucosal tissues and express an invariant Vα paired with limited Vβ T-cell receptor (TCR) chains. Furthermore, MAIT cell development is dependent upon the expression of the evolutionarily conserved major histocompatibility complex (MHC) class Ib molecule MR1. Using in vitro assays, recent studies have shown that mouse and human MAIT cells are activated by antigen-presenting cells (APCs) infected with diverse microbes, including numerous bacterial strains and yeasts, but not viral pathogens. However, whether MAIT cells play an important, and perhaps unique, role in controlling microbial infection has remained unclear. To probe MAIT cell function, we show here that purified polyclonal MAIT cells potently inhibit intracellular bacterial growth of Mycobacterium bovis BCG in macrophages (MΦ) in coculture assays, and this inhibitory activity was dependent upon MAIT cell selection by MR1, secretion of gamma interferon (IFN-γ), and an innate interleukin 12 (IL-12) signal from infected MΦ. Surprisingly, however, the cognate recognition of MR1 by MAIT cells on the infected MΦ was found to play only a minor role in MAIT cell effector function. We also report that MAIT cell-deficient mice had higher bacterial loads at early times after infection compared to wild-type (WT) mice, demonstrating that MAIT cells play a unique role among innate lymphocytes in protective immunity against bacterial infection.
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Citations
Cites
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Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17–secreting T cells
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Cited by
Ussher, J. E., Bilton, M., Attwod, E., Shadwell, J., Richardson, R., de Lara, C., Mettke, E., Kurioka, A., Hansen, T. H., Klenerman, P., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201343509 · Cited by 543
Self-citationMAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets
Kurioka, A., Ussher, J. E., Cosgrove, C., Clough, C., Fergusson, J. R., Smith, K., Kang, Y.-H., Walker, L. J., Hansen, T. H., Willberg, C. B., et al. (2015) · Mucosal Immunology · doi:10.1038/mi.2014.81 · Cited by 398
Self-citationLeeansyah, E., Ganesh, A., Quigley, M. F., Sönnerborg, A., Andersson, J., Hunt, P. W., Somsouk, M., Deeks, S. G., Martin, J. N., Moll, M., et al. (2013) · Blood · doi:10.1182/blood-2012-07-445429 · Cited by 372
IL-7 Licenses Activation of Human Liver Intrasinusoidal Mucosal-Associated Invariant T Cells
Tang, X.-Z., Jo, J., Tan, A. T., Sandalova, E., Chia, A., Tan, K. C., Lee, K. H., Gehring, A. J., De Libero, G., & Bertoletti, A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203218 · Cited by 356
Recognition of vitamin B metabolites by mucosal-associated invariant T cells
Patel, O., Kjer-Nielsen, L., Le Nours, J., Eckle, S. B. G., Birkinshaw, R., Beddoe, T., Corbett, A. J., Liu, L., Miles, J. J., Meehan, B., et al. (2013) · Nature Communications · doi:10.1038/ncomms3142 · Cited by 301
Metadata
- Authors
- Chua, W.-J., Truscott, S. M., Eickhoff, C. S., Blazevic, A., Hoft, D. F., & Hansen, T. H.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2012-09
- Volume
- 80
- Issue
- 9
- Pages
- 3256-3267
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2141895032
- Cited by
- 301
- References
- 80
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Chua, W.-J., Truscott, S. M., Eickhoff, C. S., Blazevic, A., Hoft, D. F., & Hansen, T. H. (2012). Polyclonal Mucosa-Associated Invariant T Cells Have Unique Innate Functions in Bacterial Infection. Infection and Immunity. https://doi.org/10.1128/iai.00279-12
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