The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
CD 161++CD 8+T cells, including the MAIT cell subset, are specifically activated by IL‐12+IL‐18 in a TCR‐independent manner
Open accessAbstract
CD 161++CD 8+ T cells represent a novel subset that is dominated in adult peripheral blood by mucosal‐associated invariant T (MAIT) cells, as defined by the expression of a variable‐α chain 7.2 (V α7.2)‐J α33 TCR, and IL‐18 R α. Stimulation with IL‐18+IL‐12 is known to induce IFN‐γ by both NK cells and, to a more limited extent, T cells. Here, we show the CD 161++ CD 8+ T‐cell population is the primary T‐cell population triggered by this mechanism. Both CD 161++V α7.2+ and CD 161++V α7.2− T‐cell subsets responded to IL‐12+IL‐18 stimulation, demonstrating this response was not restricted to the MAIT cells, but to the CD 161++ phenotype. Bacteria and TLR agonists also indirectly triggered IFN‐γ expression via IL‐12 and IL‐18. These data show that CD 161++ T cells are the predominant T‐cell population that responds directly to IL‐12+IL‐18 stimulation. Furthermore, our findings broaden the potential role of MAIT cells beyond bacterial responsiveness to potentially include viral infections and other inflammatory stimuli.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Cloning of a new cytokine that induces IFN-γ production by T cells
Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K., et al. (1995) · Nature · doi:10.1038/378088a0 · Cited by 2,600
MR1 presents microbial vitamin B metabolites to MAIT cells
Kjer-Nielsen, L., Patel, O., Corbett, A. J., Le Nours, J., Meehan, B., Liu, L., Bhati, M., Chen, Z., Kostenko, L., Reantragoon, R., et al. (2012) · Nature · doi:10.1038/nature11605 · Cited by 1,351
Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production
Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A., Quintal, L., Sekut, L., Talanian, R., Paskind, M., et al. (1997) · Nature · doi:10.1038/386619a0 · Cited by 1,203
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
Treiner, E., Duban, L., Bahram, S., Radosavljevic, M., Wanner, V., Tilloy, F., Affaticati, P., Gilfillan, S., & Lantz, O. (2003) · Nature · doi:10.1038/nature01433 · Cited by 1,139
Antimicrobial activity of mucosal-associated invariant T cells
Le Bourhis, L., Martin, E., Péguillet, I., Guihot, A., Froux, N., Coré, M., Lévy, E., Dusseaux, M., Meyssonnier, V., Premel, V., et al. (2010) · Nature Immunology · doi:10.1038/ni.1890 · Cited by 936
Signaling Pathways Downstream of Pattern-Recognition Receptors and Their Cross Talk
Lee, M. S., & Kim, Y.-J. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060605.122847 · Cited by 756
Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells
Gold, M. C., Cerri, S., Smyk-Pearson, S., Cansler, M. E., Vogt, T. M., Delepine, J., Winata, E., Swarbrick, G. M., Chua, W.-J., Yu, Y. Y. L., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000407 · Cited by 673
Self-citationTilloy, F., Treiner, E., Park, S.-H., Garcia, C., Lemonnier, F., de la Salle, H., Bendelac, A., Bonneville, M., & Lantz, O. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.12.1907 · Cited by 615
Micallef, M. J., Ohtsuki, T., Kohno, K., Tanabe, F., Ushio, S., Namba, M., Tanimoto, T., Torigoe, K., Fujii, M., Ikeda, M., et al. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260736 · Cited by 597
Cited by
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage
Koay, H.-F., Gherardin, N. A., Enders, A., Loh, L., Mackay, L. K., Almeida, C. F., Russ, B. E., Nold-Petry, C. A., Nold, M. F., Bedoui, S., et al. (2016) · Nature Immunology · doi:10.1038/ni.3565 · Cited by 377
Mucosal-associated invariant T cells and disease
Toubal, A., Nel, I., Lotersztajn, S., & Lehuen, A. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0191-y · Cited by 300
T cell responses in the central nervous system
Korn, T., & Kallies, A. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.144 · Cited by 268
Jeffery, H. C., van Wilgenburg, B., Kurioka, A., Parekh, K., Stirling, K., Roberts, S., Dutton, E. E., Hunter, S., Geh, D., Braitch, M. K., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.12.017 · Cited by 212
Self-citation
Metadata
- Authors
- Ussher, J. E., Bilton, M., Attwod, E., Shadwell, J., Richardson, R., de Lara, C., Mettke, E., Kurioka, A., Hansen, T. H., Klenerman, P., & Willberg, C. B.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2013-10
- Volume
- 44
- Issue
- 1
- Pages
- 195-203
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W1538607209
- Cited by
- 543
- References
- 41
- FWCI
- 11.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: CD 161++CD 8+T cells, including the MAIT cell subset, are specifically activated by IL‐12+IL‐18 in a TCR‐independent manner. https://app.cochat.ai/papers/10.1002/eji.201343509
- The paper
- Ussher, J. E., Bilton, M., Attwod, E., Shadwell, J., Richardson, R., de Lara, C., Mettke, E., Kurioka, A., Hansen, T. H., Klenerman, P., & Willberg, C. B. (2014). CD 161++CD 8+T cells, including the MAIT cell subset, are specifically activated by IL‐12+IL‐18 in a TCR‐independent manner. European Journal of Immunology. https://doi.org/10.1002/eji.201343509
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
