Lipid Transport by Candida albicans Dnf2 Is Required for Hyphal Growth and Virulence
Open accessPublished version of a preprint
Abstract
Candida albicans is a common cause of human mucosal yeast infections, and invasive candidiasis can be fatal. Antifungal medications are limited, but those targeting the pathogen cell wall or plasma membrane have been effective.
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Cites
Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764 · see citing works
<i>Candida albicans</i> pathogenicity mechanisms
Mayer, F. L., Wilson, D., & Hube, B. (2013) · Virulence · doi:10.4161/viru.22913 · Cited by 1,848 · see citing works
Antifungal Drug Resistance: Molecular Mechanisms in <i>Candida albicans</i> and Beyond
Lee, Y., Puumala, E., Robbins, N., & Cowen, L. E. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00199 · Cited by 801 · see citing works
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Lipid Flippase Subunit Cdc50 Mediates Drug Resistance and Virulence in Cryptococcus neoformans
Huang, W., Liao, G., Baker, G. M., Wang, Y., Lau, R., Paderu, P., Perlin, D. S., & Xue, C. (2016) · mBio · doi:10.1128/mbio.00478-16 · Cited by 88 · see citing works
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- Authors
- Jain, B. K., Wagner, A. S., Reynolds, T. B., & Graham, T. R.
- Affiliations
- Vanderbilt University (US)
- University of Tennessee at Knoxville (US)
- Corresponding author
- Graham, Todd R.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2022-11-17
- Volume
- 90
- Issue
- 11
- Pages
- e0041622-e0041622
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC9670988
- OpenAlex
- W4303986632
- Cited by
- 11
- References
- 5
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Infection and Immunity (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | National Institutes of Health (R35 GM144123-01, 1R01AI53599-01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida albicans, lipid transport, hyphal growth, virulence, invasive candidiasis, fungal pathogenesis, antifungal resistance
- MeSH terms
- Adenosine Triphosphatases, Animals, Candida albicans, Humans, Saccharomyces cerevisiae, Virulence, ATP-Binding Cassette Transporters, Hyphae, Membrane Transport Proteins, Saccharomyces cerevisiae Proteins, Mice
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