Effect of hypoxia on the pathogenesis of Acinetobacter baumannii and Pseudomonas aeruginosa in vitro and in murine experimental models of infection
Open accessAbstract
Hypoxia modulates bacterial virulence and the inflammation response through hypoxia-inducible factor 1α (HIF-1α). Here we study the influence of hypoxia on Acinetobacter baumannii and Pseudomonas aeruginosa infections.
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Many pathophysiologic features of anemia of chronic disease suggest that this form of anemia is an intended mechanism of defense against infections that aims at withdrawing iron, oxygen or both from pathogens.
“Many of the pathophysiologic features of ACD suggest that this form of anemia is an intended mechanism of defense against infections which aims at withdrawing iron, oxygen or both from pathogens (Gil-Marques et al., 2018;Nairz et al., 2016;Siegert et al., 2015).”
From Iron in infection and immunity (2020) · cites this paper as Gil-Marques et al., 2018
The Introduction (page unavailable) says hypoxia may protect against bacterial infections and reports reduced expression of some bacterial virulence factors under hypoxia. It does not discuss anemia of chronic disease, iron withdrawal, or whether anemia is an intended defensive mechanism. (LLM, conf=0.82)
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Self-citation
- Authors
- Gil-Marqués, M. L., Pachón-Ibáñez, M. E., Pachón, J., & Smani, Y.
- Affiliations
- Instituto de Biomedicina de Sevilla (ES)
- Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2018-10
- Volume
- 86
- Issue
- 10
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC6204731
- OpenAlex
- W2886137859
- Cited by
- 23
- References
- 49
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 3 · 2020: 8 · 2018: 1
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Infection and Immunity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, cc-by)
- Funders
- Spanish Network for Research in Infectious Diseases (RD16/0009)
- Ministerio de Educación Cultura y Deporte, Spain (FPU13/04545)
- Ministerio de Economía y Competitividad, Instituto de Salud Carlos III, Spain (RD16/0009)
- Ministerio de Economía y Competitividad (Miguel Servet tipo I), Spain, Subdirección General de Redes y Centros de Investigación Cooperativa (CP15/00132)
- EC | European Regional Development Fund (RD16/0009)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Keywords
- hypoxia, Acinetobacter baumannii, Pseudomonas aeruginosa, hypoxia-inducible factor-1α, bacterial virulence, pathogenesis, mouse infection model, inflammation
- MeSH terms
- Acinetobacter Infections, Animals, Hypoxia, Bacterial Adhesion, Humans, Macrophages, Male, Mice, Inbred C57BL, Oxygen, Pseudomonas aeruginosa, Pseudomonas Infections, Virulence, Acinetobacter baumannii, Microbial Viability, Mice, Hypoxia-Inducible Factor 1, alpha Subunit
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