The DOI matches its Crossref record; 178 of the 179 references it cites were found in a registry or an index.
Sequestration and Scavenging of Iron in Infection
Open accessAbstract
The proliferative capability of many invasive pathogens is limited by the bioavailability of iron. Pathogens have thus developed strategies to obtain iron from their host organisms. In turn, host defense strategies have evolved to sequester iron from invasive pathogens. This review explores the mechanisms employed by bacterial pathogens to gain access to host iron sources, the role of iron in bacterial virulence, and iron-related genes required for the establishment or maintenance of infection. Host defenses to limit iron availability for bacterial growth during the acute-phase response and the consequences of iron overload conditions on susceptibility to bacterial infection are also examined. The evidence summarized herein demonstrates the importance of iron bioavailability in influencing the risk of infection and the ability of the host to clear the pathogen.
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“As such, host defense mechanisms act to sequester free iron away from invading pathogens [33].”
From Associations of genetically determined iron status across the phenome: A mendelian randomization study (2019) · cites this paper as [33]
Citations
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Norden, D. M., Trojanowski, P. J., Villanueva, E., Navarro, E., & Godbout, J. P. (2015) · Glia · doi:10.1002/glia.22930 · Cited by 623
Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis
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Porcheron, G., Garénaux, A., Proulx, J., Sabri, M., & Dozois, C. M. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00090 · Cited by 385
Host-Associated Probiotics: A Key Factor in Sustainable Aquaculture
Doan, H. V., Hoseinifar, S. H., Ringø, E., Esteban, M. Á., Dadar, M., Dawood, M. A. O., & Faggio, C. (2019) · Reviews in Fisheries Science & Aquaculture · doi:10.1080/23308249.2019.1643288 · Cited by 365
Metadata
- Authors
- Parrow, N. L., Fleming, R. E., & Minnick, M. F.
- Affiliations
- National Institutes of Health (US)
- Saint Louis University (US)
- University of Montana (US)
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2013-10
- Volume
- 81
- Issue
- 10
- Pages
- 3503-3514
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC3811770
- OpenAlex
- W2126286427
- Cited by
- 261
- References
- 179
- Citations by year
- 2026: 14 · 2025: 26 · 2024: 25 · 2023: 24 · 2022: 25 · 2021: 26 · 2020: 31 · 2019: 26 · 2018: 16 · 2017: 16 · 2016: 11 · 2015: 11 · 2014: 8 · 2013: 1
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Mathematics Enthusiast (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Keywords
- iron sequestration, iron scavenging, iron bioavailability, bacterial virulence, host-pathogen interaction, acute phase response, iron overload, bacterial iron acquisition, host defense against infection
- MeSH terms
- Animals, Bacteria, Homeostasis, Humans, Iron
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