Cited by 261Iron Metabolism and DisordersBacterial Genetics and BiotechnologyEscherichia coli research studies

The DOI matches its Crossref record; 178 of the 179 references it cites were found in a registry or an index.

Sequestration and Scavenging of Iron in Infection

Open access

Parrow, Nermi L., Fleming, Robert E., Minnick, Michael F.·2013·Infection and Immunity

Open this paper in CoChat — free account Open PDF

Abstract

The proliferative capability of many invasive pathogens is limited by the bioavailability of iron. Pathogens have thus developed strategies to obtain iron from their host organisms. In turn, host defense strategies have evolved to sequester iron from invasive pathogens. This review explores the mechanisms employed by bacterial pathogens to gain access to host iron sources, the role of iron in bacterial virulence, and iron-related genes required for the establishment or maintenance of infection. Host defenses to limit iron availability for bacterial growth during the acute-phase response and the consequences of iron overload conditions on susceptibility to bacterial infection are also examined. The evidence summarized herein demonstrates the importance of iron bioavailability in influencing the risk of infection and the ability of the host to clear the pathogen.

Integrity signals

Registry

Crossref · 10.1128/iai.00602-13

Cites

178 of 178 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166
Bacterial iron homeostasis
Andrews, S. C., Robinson, A. K., & Rodríguez-Quiñones, F. (2003) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(03)00055-x · Cited by 2,702
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., & Ganz, T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420945 · Cited by 2,650 · cited 11×
“The APR markedly alters host iron metabolism in ways that serve to minimize iron bioavailability to pathogens (Fig.”
BackgroundInfluential
The catalytic decomposition of hydrogen peroxide by iron salts
Haber, F., & Weiss, J. (1934) · Proceedings of the Royal Society of London. Series A - Mathematical and Physical Sciences · doi:10.1098/rspa.1934.0221 · Cited by 2,571
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
Krause, A., Neitz, S., Mägert, H.-J., Schulz, A., Forssmann, W.-G., Schulz-Knappe, P., & Adermann, K. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01920-7 · Cited by 1,324
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A., & Vaulont, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215686 · Cited by 1,214

Show all 179 references

Research works printed but not linked: 1

ChaberekSMartellAE. 1959. Organic sequestering agents. John Wiley & Sons, Inc, New York, NY.

Sorted by citations

Staphylococcal Biofilm Development: Structure, Regulation, and Treatment Strategies
Schilcher, K., & Horswill, A. R. (2020) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00026-19 · Cited by 762
Sequential activation of microglia and astrocyte cytokine expression precedes increased iba‐1 or GFAP immunoreactivity following systemic immune challenge
Norden, D. M., Trojanowski, P. J., Villanueva, E., Navarro, E., & Godbout, J. P. (2015) · Glia · doi:10.1002/glia.22930 · Cited by 623
Anemia and iron metabolism in COVID-19: a systematic review and meta-analysis
Taneri, P. E., Gómez-Ochoa, S. A., Llanaj, E., Raguindin, P. F., Rojas, L. Z., Roa-Díaz, Z. M., Salvador, D., Groothof, D., Minder, B., Kopp-Heim, D., et al. (2020) · European Journal of Epidemiology · doi:10.1007/s10654-020-00678-5 · Cited by 369
Iron, copper, zinc, and manganese transport and regulation in pathogenic Enterobacteria: correlations between strains, site of infection and the relative importance of the different metal transport systems for virulence
Porcheron, G., Garénaux, A., Proulx, J., Sabri, M., & Dozois, C. M. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00090 · Cited by 385
Host-Associated Probiotics: A Key Factor in Sustainable Aquaculture
Doan, H. V., Hoseinifar, S. H., Ringø, E., Esteban, M. Á., Dadar, M., Dawood, M. A. O., & Faggio, C. (2019) · Reviews in Fisheries Science & Aquaculture · doi:10.1080/23308249.2019.1643288 · Cited by 365
M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity
Khan, N., Downey, J., Sanz, J., Kaufmann, E., Blankenhaus, B., Pacis, A., Pernet, E., Ahmed, E. A., Cardoso, S., Nijnik, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.09.062 · Cited by 306
Do Iron Oxide Nanoparticles Have Significant Antibacterial Properties?
Gudkov, S. V., Burmistrov, D. E., Serov, D. A., Ребезов, М. Б., Semenova, A., & Lisitsyn, A. B. (2021) · Antibiotics · doi:10.3390/antibiotics10070884 · Cited by 300
The Review of Current Knowledge on Neutrophil Gelatinase-Associated Lipocalin (NGAL)
Romejko, K., Markowska, M., & Niemczyk, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310470 · Cited by 264
Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace
Ramirez, M. S., Bonomo, R. A., & Tolmasky, M. E. (2020) · Biomolecules · doi:10.3390/biom10050720 · Cited by 245
Sepsis: mechanisms of bacterial injury to the patient
Minasyan, H. A. (2019) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/s13049-019-0596-4 · Cited by 235
Cell-surface signaling in Pseudomonas: stress responses, iron transport, and pathogenicity
Llamas, M. A., Imperi, F., Visca, P., & Lamont, I. L. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12078 · Cited by 176
Bioinorganic antimicrobial strategies in the resistance era
Regiel-Futyra, A., Dąbrowski, J. M., Mazuryk, O., Śpiewak, K., Kyzioł, A., Pucelik, B., Brindell, M., & Stochel, G. (2017) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.05.005 · Cited by 168
Ferroptotic stress promotes macrophages against intracellular bacteria
Ma, R., Fang, L., Chen, L., Wang, X., Jiang, J., & Gao, L. (2022) · Theranostics · doi:10.7150/thno.66663 · Cited by 167
Immune dysfunction in cirrhosis
Sipeki, N. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i10.2564 · Cited by 166
Inflammation-associated Adherent-invasive Escherichia coli Are Enriched in Pathways for Use of Propanediol and Iron and M-cell Translocation
Dogan, B., Suzuki, H., Herlekar, D., Sartor, R. B., Campbell, B. J., Roberts, C. L., Stewart, K., Scherl, E., Araz, Y., Bitar, P. P., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000183 · Cited by 160
Iron Acquisition Systems of Gram-negative Bacterial Pathogens Define TonB-Dependent Pathways to Novel Antibiotics
Klebba, P. E., Newton, S. M. C., Six, D. A., Kumar, A., Yang, T., Nairn, B. L., Munger, C., & Chakravorty, S. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01005 · Cited by 150
Interactions of Aspergillus fumigatus Conidia with Airway Epithelial Cells: A Critical Review
Croft, C. A., Culibrk, L., Moore, M. M., & Tebbutt, S. J. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00472 · Cited by 142
Extensive horizontal gene transfer in cheese-associated bacteria
Bonham, K. S., Wolfe, B. E., & Dutton, R. J. (2017) · eLife · doi:10.7554/elife.22144 · Cited by 135
Selection and validation of reference genes for gene expression studies in Klebsiella pneumoniae using Reverse Transcription Quantitative real-time PCR
Gomes, A. É. I., Stuchi, L. P., Siqueira, N. M. G., Henrique, J. B., Vicentini, R., Ribeiro, M. L., Darrieux, M., & Ferraz, L. F. C. (2018) · Scientific Reports · doi:10.1038/s41598-018-27420-2 · Cited by 127
Role of iron in the pathogenesis of respiratory disease
Ali, M. K., Kim, R., Karim, R., Mayall, J., Martin, K. L., Shahandeh, A., Abbasian, F., Starkey, M. R., Loustaud-Ratti, V., Johnstone, D. M., et al. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.05.003 · Cited by 114
Neutrophil gelatinase-associated lipocalin and innate immune responses to bacterial infections
Nasioudis, D., & Witkin, S. S. (2015) · Medical Microbiology and Immunology · doi:10.1007/s00430-015-0394-1 · Cited by 106
Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species
Butt, A. T., & Thomas, M. S. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00460 · Cited by 103
Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles
Bardestani, A., Ebrahimpour, S., Esmaeili, A., & Esmaeili, A. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01059-0 · Cited by 106
Compartmentalization of iron between mitochondria and the cytosol and its regulation
Mühlenhoff, U., Hoffmann, B., Richter, N., Rietzschel, N., Spantgar, F., Stehling, O., Uzarska, M. A., & Lill, R. (2015) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2015.05.003 · Cited by 95
Bacterial Chat: Intestinal Metabolites and Signals in Host-Microbiota-Pathogen Interactions
Lustri, B. C., Sperandio, V., & Moreira, C. G. (2017) · Infection and Immunity · doi:10.1128/iai.00476-17 · Cited by 98
Ferroptosis in viral infection: the unexplored possibility
Wang, M., Banda, J., Jin, N., Du, S., & Li, C. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00814-1 · Cited by 92
Molecular basis of host specificity in human pathogenic bacteria
Pan, X., Yang, Y., & Zhang, J. (2014) · Emerging Microbes & Infections · doi:10.1038/emi.2014.23 · Cited by 82
The Small RNA RyhB Contributes to Siderophore Production and Virulence of Uropathogenic Escherichia coli
Porcheron, G., Habib, R., Houle, S., Caza, M., Lepine, F. L., Daigle, F., Massé, É., & Dozois, C. M. (2014) · Infection and Immunity · doi:10.1128/iai.02287-14 · Cited by 80
Interaction between host genes and Mycobacterium tuberculosis lineage can affect tuberculosis severity: Evidence for coevolution?
McHenry, M. L., Bartlett, J., Igo, R. P., Wampande, E. M., Benchek, P. H., Mayanja‐Kizza, H., Fluegge, K., Hall, N. B., Gagneux, S., Tishkoff, S. A., et al. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008728 · Cited by 79
Key players in the regulation of iron homeostasis at the host-pathogen interface
Ullah, I., & Lang, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1279826 · Cited by 80
Anemia and iron metabolism in COVID-19: A systematic review and meta-analysis
Taneri, P. E., Alejandro Gómez-Ochoa, S., Llanaj, E., Francis Raguindin, P., Rojas, L. Z., Wyssmann, B. M., Kopp-Heim, D., Hautz, W. E., Eisenga, M. F., Franco, O. H., et al. (2020) · doi:10.1101/2020.06.04.20122267 · Cited by 72
H-Ferritin is essential for macrophages’ capacity to store or detoxify exogenously added iron
Mesquita, G., Silva, T., Gomes, A. C., Oliveira, P. F., Alves, M. G., Fernandes, R., Almeida, A. A., Moreira, A. C., & Gomes, M. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-59898-0 · Cited by 69
Associations of genetically determined iron status across the phenome: A mendelian randomization study
Gill, D., Benyamin, B., Moore, L. S. P., Monori, G., Zhou, A., Koskeridis, F., Evangelou, E., Laffan, M., Walker, A. P., Tsilidis, K. K., et al. (2019) · PLOS Medicine · doi:10.1371/journal.pmed.1002833 · Cited by 63
Nanocolloidal Hydrogel with Sensing and Antibacterial Activities Governed by Iron Ion Sequestration
Chekini, M., Krivoshapkina, E. F., Shkodenko, L. A., Koshel, E. I., Shestovskaya, M. V., Dukhinova, M., Kheiri, S., Khuu, N., & Kumacheva, E. (2020) · Chemistry of Materials · doi:10.1021/acs.chemmater.0c03362 · Cited by 63
Human Antimicrobial Peptides in Bodily Fluids: Current Knowledge and Therapeutic Perspectives in the Postantibiotic Era
Bastos, P. A. D., Trindade, F., da Costa, J. P., Ferreira, R. M., & Vitorino, R. M. P. (2017) · Medicinal Research Reviews · doi:10.1002/med.21435 · Cited by 63
Iron imbalance in cancer: Intersection of deficiency and overload
Basak, T., & Kanwar, R. K. (2022) · Cancer Medicine · doi:10.1002/cam4.4761 · Cited by 60
Iron acquisition in the cystic fibrosis lung and potential for novel therapeutic strategies
Tyrrell, J., & Callaghan, M. (2016) · Microbiology · doi:10.1099/mic.0.000220 · Cited by 56
The fungus Colletotrichum as a source for bioactive secondary metabolites
Kim, J. W., & Shim, S. H. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01142-z · Cited by 59
Iron in Lung Pathology
Zhang, V., Nemeth, E., & Kim, A. (2019) · Pharmaceuticals · doi:10.3390/ph12010030 · Cited by 57
Pseudomonas aeruginosa possesses three distinct systems for sensing and using the host molecule haem
Otero‐Asman, J. R., García‐García, A. I., Civantos, C., Quesada, J. M., & Llamas, M. A. (2019) · Environmental Microbiology · doi:10.1111/1462-2920.14773 · Cited by 54
Clostridioides difficile ferrosome organelles combat nutritional immunity
Pi, H., Sun, R., McBride, J. R., Kruse, A. R. S., Gibson-Corley, K. N., Krystofiak, E. S., Nicholson, M. R., Spraggins, J. M., Zhou, Q., & Skaar, E. P. (2023) · Nature · doi:10.1038/s41586-023-06719-9 · Cited by 54
Environmental determinants of pyoverdine production, exploitation and competition in natural Pseudomonas communities
Butaitė, E., Kramer, J., Wyder, S., & Kümmerli, R. (2018) · Environmental Microbiology · doi:10.1111/1462-2920.14355 · Cited by 55
Hepcidin, iron, and bacterial infection
Barton, J. C., & Acton, R. T. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2019.01.011 · Cited by 53
The ‘Whey’ to good health: Whey protein and its beneficial effect on metabolism, gut microbiota and mental health
Boscaini, S., Skuse, P., Nilaweera, K. N., Cryan, J. F., & Cotter, P. D. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.12.009 · Cited by 59
Catechol Siderophore Transport by Vibrio cholerae
Wyckoff, E. E., Allred, B. E., Raymond, K. N., & Payne, S. M. (2015) · Journal of Bacteriology · doi:10.1128/jb.00417-15 · Cited by 53
Epithelial cell function and remodeling in nasal polyposis
Bankova, L. G., & Barrett, N. A. (2020) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2020.01.018 · Cited by 55
Evaluating the in vitro efficacy of bovine lactoferrin products against SARS-CoV-2 variants of concern
Wotring, J. W., Fursmidt, R. M., Ward, L. S., & Sexton, J. Z. (2022) · Journal of Dairy Science · doi:10.3168/jds.2021-21247 · Cited by 52
COVID-19 during Gestation: Maternal Implications of Evoked Oxidative Stress and Iron Metabolism Impairment
Moreno‐Fernández, J., Ochoa, J. J., Matallana, C. D. P., Caño, Á., Martín‐Álvarez, E., Sánchez‐Romero, J., Toledano, J. M., Puche-Juárez, M., Prados, S., Ruiz‐Durán, S., et al. (2022) · Antioxidants · doi:10.3390/antiox11020184 · Cited by 51
Evaluation of Gallium Citrate Formulations against a Multidrug-Resistant Strain of Klebsiella pneumoniae in a Murine Wound Model of Infection
Thompson, M. G., Truong-Le, V. L., Alamneh, Y. A., Black, C. C., Anderl, J. N., Honnold, C. L., Pavlicek, R. L., Abu-Taleb, R., Wise, M. C., Hall, E. R., et al. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00882-15 · Cited by 52
Transferrin-mediated iron sequestration suggests a novel therapeutic strategy for controlling Nosema disease in the honey bee, Apis mellifera
Rodríguez-García, C., Heerman, M. C., Cook, S. C., Evans, J. D., DeGrandi-Hoffman, G., Banmeke, O., Zhang, Y., Huang, S., Hamilton, M., & Chen, Y. P. (2021) · PLOS Pathogens · doi:10.1371/journal.ppat.1009270 · Cited by 50
Virulence mechanisms of vibrios belonging to the Splendidus clade as aquaculture pathogens, from case studies and genome data
Zhang, W., & Li, C. (2021) · Reviews in Aquaculture · doi:10.1111/raq.12555 · Cited by 55
Bacterial metabolism in the host and its association with virulence
Bhagwat, A. C., Haldar, T., Kanojiya, P., & Saroj, S. D. (2025) · Virulence · doi:10.1080/21505594.2025.2459336 · Cited by 51
Immunodeficiency caused by cirrhosis
Tuchendler, E., Tuchendler, P., & Madej, G. (2018) · Clinical and Experimental Hepatology · doi:10.5114/ceh.2018.78119 · Cited by 48
ATP Exhibits Antimicrobial Action by Inhibiting Bacterial Utilization of Ferric Ions
Tatano, Y., Kanehiro, Y., Sano, C., Shimizu, T., & Tomioka, H. (2015) · Scientific Reports · doi:10.1038/srep08610 · Cited by 46
Do Bacterial “Virulence Factors” Always Increase Virulence? A Meta-Analysis of Pyoverdine Production in Pseudomonas aeruginosa As a Test Case
Granato, E. T., Harrison, F., Kümmerli, R., & Ross‐Gillespie, A. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01952 · Cited by 43
Pathogen avoidance within an integrated immune system: Multiple components with distinct costs and benefits.
Gangestad, S. W., & Grebe, N. M. (2014) · Evolutionary Behavioral Sciences · doi:10.1037/ebs0000023 · Cited by 43
Antimicrobial Activity of Gallium(III) Compounds: Pathogen-Dependent Targeting of Multiple Iron/Heme-Dependent Biological Processes
Choi, S., Hassan, M., Britigan, B. E., & Narayanasamy, P. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46080541 · Cited by 44
Hybridization-based capture of pathogen mRNA enables paired host-pathogen transcriptional analysis
Betin, V., Peñaranda, C., Bandyopadhyay, N., Yang, R., Abitua, A., Bhattacharyya, R. P., Fan, A. C., Avraham, R., Livny, J., Noam Shoresh, F., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-55633-6 · Cited by 40
The applications of 3D printing in wound healing: The external delivery of stem cells and antibiosis
Yu, Q., Wang, Q., Zhang, L., Deng, W., Cao, X., Wang, Z., Sun, X., Yu, J., & Xu, X. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114823 · Cited by 40
Diversity of extracytoplasmic function sigma (σ ECF ) factor‐dependent signaling in Pseudomonas
Otero‐Asman, J. R., Wettstadt, S., Bernal, P., & Llamas, M. A. (2019) · Molecular Microbiology · doi:10.1111/mmi.14331 · Cited by 39
Advances in Ferritin Physiology and Possible Implications in Bacterial Infection
Gehrer, C. M., Mitterstiller, A., Grubwieser, P., Meyron‐Holtz, E. G., Weiß, G., & Nairz, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054659 · Cited by 42
Human Colon Mucosal Biofilms and Murine Host Communicate via Altered mRNA and microRNA Expression during Cancer
Tomkovich, S., Gharaibeh, R. Z., Dejea, C. M., Pope, J. L., Jiang, J., Winglee, K., Gauthier, J., Newsome, R. C., Yang, Y., Fodor, A. A., et al. (2020) · mSystems · doi:10.1128/msystems.00451-19 · Cited by 40
Structural and Functional Characterization of Aerobactin Synthetase IucA from a Hypervirulent Pathotype of Klebsiella pneumoniae
Bailey, D. C., Drake, E. J., Grant, T. D., & Gulick, A. M. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00409 · Cited by 40
Interferon-gamma promotes iron export in human macrophages to limit intracellular bacterial replication
Abreu, R., Essler, L., Giri, P., & Quinn, F. (2020) · PLOS ONE · doi:10.1371/journal.pone.0240949 · Cited by 37
Longitudinal Transcriptomic, Proteomic, and Metabolomic Analysis of Citrus limon Response to Graft Inoculation by Candidatus Liberibacter asiaticus
Ramsey, J. S., Chin, E. L., Chavez, J. D., Saha, S., Mischuk, D., Mahoney, J. E., Mohr, J. P., Robison, F., Mitrovic, E., Xu, Y., et al. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00802 · Cited by 36
Approaches to Understanding Mechanisms of Dentilisin Protease Complex Expression in Treponema denticola
Goetting‐Minesky, M. P., Godovikova, V., & Fenno, J. C. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.668287 · Cited by 35
The Serratia marcescens Siderophore Serratiochelin Is Necessary for Full Virulence during Bloodstream Infection
Weakland, D. R., Smith, S. N., Bell, B. A., Tripathi, A., & Mobley, H. L. T. (2020) · Infection and Immunity · doi:10.1128/iai.00117-20 · Cited by 34
In-vivo microscopy reveals the impact of Pseudomonas aeruginosa social interactions on host colonization
Rezzoagli, C., Granato, E. T., & Kümmerli, R. (2019) · The ISME Journal · doi:10.1038/s41396-019-0442-8 · Cited by 31
Direct Detection of Fungal Siderophores on Bats with White-Nose Syndrome via Fluorescence Microscopy-Guided Ambient Ionization Mass Spectrometry
Mascuch, S. J., Moree, W. J., Hsu, C., Turner, G. G., Cheng, T. L., Blehert, D. S., Kilpatrick, A. M., Frick, W. F., Meehan, M. J., Dorrestein, P. C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119668 · Cited by 32
Trauma-induced heme release increases susceptibility to bacterial infection
Lee, G. R., Gallo, D. J., de Souza, R. W. A., Tiwari‐Heckler, S., Csizmadia, E., Harbison, J., Shankar, S., Banner‐Goodspeed, V., Yaffe, M. B., Longhi, M. S., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.150813 · Cited by 32
Functional Characterization of FeoAB in Iron Acquisition and Pathogenicity in Riemerella anatipestifer
Huang, M. N., Wang, M., Feng, Y., Wang, M., Gao, Q., Zhu, D., Jia, R., Chen, S., Zhao, X., Yang, Q., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.01373-23 · Cited by 32
Characterization of Foot and Mouth Disease Virus Serotype SAT-2 in Swamp Water Buffaloes (Bubalus bubalis) under the Egyptian Smallholder Production System
Damaty, H. M. E., Fawzi, E. M., Neamat‐Allah, A. N. F., Elsohaby, I., Abdallah, A., Farag, G. K., El-Shazly, Y. A., & Mahmmod, Y. S. (2021) · Animals · doi:10.3390/ani11061697 · Cited by 31
Donor-dependent fecal microbiota transplantation efficacy against necrotizing enterocolitis in preterm pigs
Yan, H., Vestergaard, G., Deng, L., Kot, W., Thymann, T., Brunse, A., & Nielsen, D. S. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00310-2 · Cited by 31
Sickness-Associated Anorexia: Mother Nature’s Idea of Immunonutrition?
van Niekerk, G., Isaacs, A. W., Nell, T. A., & Engelbrecht, A. (2016) · Mediators of Inflammation · doi:10.1155/2016/8071539 · Cited by 32
Transcriptional response of Clostridium difficile to low iron conditions
Hastie, J. L., Hanna, P. C., & Carlson, P. E. (2018) · Pathogens and Disease · doi:10.1093/femspd/fty009 · Cited by 27
Proteome analysis of Bordetella pertussis isolated from human macrophages
Lamberti, Y., Cafiero, J. H., Surmann, K., Valdez, H., Holubová, J., Večerek, B., Šebo, P., Schmidt, F., Völker, U., & Rodrı́guez, M. E. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.02.002 · Cited by 29
Haptoglobin improves acute phase response and endotoxin tolerance in response to bacterial LPS
Raju, S. M., Kumar, A., Yadav, A. N., Rajkumar, K., Sandhya, M. V. S., & Burgula, S. (2019) · Immunology Letters · doi:10.1016/j.imlet.2019.01.002 · Cited by 29
Near‐Infrared‐Light‐Triggered Antimicrobial Indium Phosphide Quantum Dots
Levy, M., Bertram, J. R., Eller, K. A., Chatterjee, A., & Nagpal, P. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201906501 · Cited by 29
How to kill Pseudomonas —emerging therapies for a challenging pathogen
Yaeger, L. N., Coles, V. E., Chan, D. C. K., & Burrows, L. L. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14596 · Cited by 31
Immunoceuticals: Harnessing Their Immunomodulatory Potential to Promote Health and Wellness
Tieu, S., Charchoglyan, A., Wagter-Lesperance, L., Karimi, K., Bridle, B. W., Karrow, N. A., & Mallard, B. A. (2022) · Nutrients · doi:10.3390/nu14194075 · Cited by 32
MARTX Toxin in the Zoonotic Serovar of Vibrio vulnificus Triggers an Early Cytokine Storm in Mice
Murciano, C., Lee, C.-T., Fernández-Bravo, A., Hsieh, T.-H., Fouz, B., Hor, L., & Amaro, C. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00332 · Cited by 29
Production and Uptake of Distinct Endogenous Catecholate-Type Siderophores Are Required for Iron Acquisition and Virulence in Chromobacterium violaceum
Batista, B. B., Santos, R. E. R. D. S., Ricci-Azevedo, R., & Neto, J. F. D. S. (2019) · Infection and Immunity · doi:10.1128/iai.00577-19 · Cited by 28
Exploring the Immunomodulatory Moonlighting Activities of Acute Phase Proteins for Tolerogenic Dendritic Cell Generation
Serrano, I., Luque, A., & Aran, J. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00892 · Cited by 28
How Severe Anaemia Might Influence the Risk of Invasive Bacterial Infections in African Children
Abuga, K. M., Muriuki, J. M., Williams, T. N., & Atkinson, S. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186976 · Cited by 32
The Microbiota–Gut–Brain Axis Heart Shunt Part I: The French Paradox, Heart Disease and the Microbiota
Obrenovich, M. E., Siddiqui, B., McCloskey, B., & Reddy, V. P. (2020) · Microorganisms · doi:10.3390/microorganisms8040490 · Cited by 29
The important lessons lurking in the history of meningococcal epidemiology
Borrow, R., & Findlow, J. (2024) · Expert Review of Vaccines · doi:10.1080/14760584.2024.2329618 · Cited by 26
Host Iron Nutritional Immunity Induced by a Live Yersinia pestis Vaccine Strain Is Associated with Immediate Protection against Plague
Zauberman, A., Vagima, Y., Tidhar, A., Aftalion, M., Gur, D., Rotem, S., Chitlaru, T., Levy, Y., & Mamroud, E. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00277 · Cited by 28
DNA Viremia Is Associated with Hyperferritinemia in Pediatric Sepsis
Simon, D. W., Halstead, E. S., Davila, S., Kernan, K. F., Clark, R. S. B., Storch, G. A., & Carcillo, J. A. (2019) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2019.06.033 · Cited by 27
A heme‐binding protein produced by Haemophilus haemolyticus inhibits non‐typeable Haemophilus influenzae
Latham, R. D., Torrado, M., Atto, B., Walshe, J. L., Wilson, R., Guss, J. M., Mackay, J. P., Tristram, S. G., & Gell, D. A. (2019) · Molecular Microbiology · doi:10.1111/mmi.14426 · Cited by 24
Virulence genes and previously unexplored gene clusters in four commensal Neisseria spp. isolated from the human throat expand the neisserial gene repertoire
Calder, A., Menkiti, C. J., Çağdaş, A., Santos, J. L., Streich, R., Wong, A., Avini, A. H., Bojang, E., Yogamanoharan, K., Sivanesan, N., et al. (2020) · Microbial Genomics · doi:10.1099/mgen.0.000423 · Cited by 25
Protein and Microbial Biomarkers in Sputum Discern Acute and Latent Tuberculosis in Investigation of Pastoral Ethiopian Cohort
Hailemariam, M., Yu, Y., Singh, H., Teklu, T., Wondale, B., Worku, A., Zewude, A., Mounaud, S. H., Tsitrin, T., Legesse, M., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.595554 · Cited by 26
Proteomic analysis of iron-regulated membrane proteins identify FhuE receptor as a target to inhibit siderophore-mediated iron acquisition in Acinetobacter baumannii
Tiwari, V., Rajeswari, M. R., & Tiwari, M. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.12.173 · Cited by 26
comparative profile of heme acquisition genes in disease-causing and colonizing nontypeable Haemophilus influenzae and Haemophilus haemolyticus
Hariadi, N. I., Zhang, L., Patel, M., Sandstedt, S. A., Davis, G. S., Marrs, C. F., & Gilsdorf, J. R. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.00345-15 · Cited by 24
Plasmids in the human gut reveal neutral dispersal and recombination that is overpowered by inflammatory diseases
Zorea, A., Pellow, D., Levin, L., Pilosof, S., Friedman, J., Ron Shamir, A., & Mizrahi, I. (2024) · Nature Communications · doi:10.1038/s41467-024-47272-x · Cited by 24
Virulence and pathogenicity of group B Streptococcus : Virulence factors and their roles in perinatal infection
Megli, C. J., Carlin, S. M., Giacobe, E. J., Hillebrand, G. H., & Hooven, T. A. (2025) · Virulence · doi:10.1080/21505594.2025.2451173 · Cited by 24
Analysis of the Genome and Mobilome of a Dissimilatory Arsenate Reducing Aeromonas sp. O23A Reveals Multiple Mechanisms for Heavy Metal Resistance and Metabolism
Uhrynowski, W., Decewicz, P., Dziewit, Ł., Radlińska, M., Krawczyk, P. S., Lipiński, L., Adamska, D., & Drewniak, Ł. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00936 · Cited by 24
Lower incidence of respiratory infections among iron-deficient children in Kilimanjaro, Tanzania
Wander, K., Shell‐Duncan, B., & Brindle, E. (2017) · Evolution Medicine and Public Health · doi:10.1093/emph/eox010 · Cited by 23
Characteristics of the iron uptake-related process of a pathogenic Vibrio splendidus strain associated with massive mortalities of the sea cucumber Apostichopus japonicus
Song, T., Liu, H., Lv, T., Zhao, X., Shao, Y., Han, Q., Li, C., & Zhang, W. (2018) · Journal of Invertebrate Pathology · doi:10.1016/j.jip.2018.05.001 · Cited by 24
Evidence for inoculum size and gas interfaces as critical factors in bacterial biofilm formation on magnesium implants in an animal model
Rahim, M. I., Szafrański, S. P., Ingendoh‐Tsakmakidis, A., Stiesch, M., & Mueller, P. P. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.110684 · Cited by 22
Prevalence of anemia and its associated factors among children aged 6–23 months, in Ethiopia: a systematic review and meta analysis
Azmeraw, M., Kassaw, A., Habtegiorgis, S. D., Tigabu, A., Amare, A. T., Tegegne, K. M., Temesgen, D., Zemariam, A. B., Kerebeh, G., Bantie, B., et al. (2023) · BMC Public Health · doi:10.1186/s12889-023-17330-y · Cited by 32

Authors: Parrow, N. L., Fleming, R. E., & Minnick, M. F.
Affiliations: National Institutes of Health (US)
Saint Louis University (US)
University of Montana (US)
ORCID: Parrow, Nermi L.
Fleming, Robert E.
Minnick, Michael F.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2013-10
Volume: 81
Issue: 10
Pages: 3503-3514
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.00602-13
PMC: PMC3811770
OpenAlex: W2126286427
Cited by: 261
References: 179
Citations by year: 2026: 14 · 2025: 26 · 2024: 25 · 2023: 24 · 2022: 25 · 2021: 26 · 2020: 31 · 2019: 26 · 2018: 16 · 2017: 16 · 2016: 11 · 2015: 11 · 2014: 8 · 2013: 1
FWCI: 7.42
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The Mathematics Enthusiast (submittedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
Keywords: iron sequestration, iron scavenging, iron bioavailability, bacterial virulence, host-pathogen interaction, acute phase response, iron overload, bacterial iron acquisition, host defense against infection
MeSH terms: Animals, Bacteria, Homeostasis, Humans, Iron

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Sequestration and Scavenging of Iron in Infection

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks