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Type-common and type-specific monoclonal antibody to herpes simplex virus type 1
Open accessAbstract
Hybridoma cells produced by fusing mouse myeloma cells with spleen cells from mice primed with herpes simplex virus (HSV) type 1 yielded five clones producing neutralizing antibody against homologous virus. Two clones, HCl and HC2, produced antibody capable of precipitating glycoprotein C and its precursor, whereas three clones, HD1, HD2, and HD3, produced antibody capable of precipitating glycoprotein D and its precursor. Antibody produced by the HC1 and HC2 clones neutralized HSV type 1 but not HSV type 2 or HSV type 1 strain MP, which is known to lack glycoprotein C. Antibody produced by the HD1 and HD2 clones neutralized both HSV type 1 and HSV type 2, whereas antibody produced by the HD3 clone neutralized HSV type 1 but not HSV type 2. The two clones which produced antibody to glycoprotein C and the two clones which produced type-common antibody to glycoprotein D were independently derived and not clonally related inasmuch as the antibody in each pair belonged to a different subclass of immunoglobulin.
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Cited by
Vidarabine versus Acyclovir Therapy in Herpes Simplex Encephalitis
Whitley, R. J., Alford, C. A., Hirsch, M. S., Schooley, R. T., Luby, J. P., Aoki, F. Y., Hanley, D., Nahmias, A. J., Soong, S.-J., & The NIAID Collaborative Antiviral Study Group* (1986) · New England Journal of Medicine · doi:10.1056/nejm198601163140303 · Cited by 896
Showalter, S. D., Zweig, M., & Hampar, B. (1981) · Infection and Immunity · doi:10.1128/iai.34.3.684-692.1981 · Cited by 435
The virological synapse facilitates herpes simplex virus entry into T cells
Aubert, M., Yoon, M., Sloan, D. D., Spear, P. G., & Jerome, K. R. (2009) · Journal of Virology · doi:10.1128/jvi.02163-08 · Cited by 52
Metadata
- Authors
- Pereira, L., Klassen, T., & Baringer, J. R.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1980-08
- Volume
- 29
- Issue
- 2
- Pages
- 724-732
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2105258399
- Cited by
- 238
- References
- 0
- FWCI
- 23.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Pereira, L., Klassen, T., & Baringer, J. R. (1980). Type-common and type-specific monoclonal antibody to herpes simplex virus type 1. Infection and Immunity. https://doi.org/10.1128/iai.29.2.724-732.1980
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