The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Possible importance of macrophage-derived mediators in acute malaria
Open accessAbstract
Tumor necrosis factor, lymphocyte-activating factor, and enhanced levels of type I interferon were found in serum samples taken 2 h after mice infected with Plasmodium vinckei subsp. petteri received a small intravenous injection of endotoxin. These three mediators are among those released when mice receive an endotoxin injection 2 weeks after Mycobacterium bovis BCG or Corynebacterium parvum have been administered. There is indirect evidence that this wider range of mediators is also released in P. vinckei subsp. petteri-infected mice given parenteral endotoxin. A recent report that endotoxin is detectable in the plasma of malaria-infected mice and children implies that these mediators may also be released in the acute phase of the natural infection. We propose that these macrophage-derived mediators may be important in the glucocorticoid antagonism, bone marrow depression, fever, hypergammaglobulinemia, splenomegaly, elevation of serum amyloid A, consumptive coagulopathy, and shock syndrome with associated organ damage which can accompany malaria. The intraerythrocytic parasite death seen at crisis in some malarias, as well as the subsequent development of specific protective immunity, may also depend on these mediators.
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Clark, I. A., & Vissel, B. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0708-2 · Cited by 123
Self-citationClark, I. A., & Vissel, B. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13181 · Cited by 84
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Metadata
- Authors
- Clark, I. A., Virelizier, J. L., Carswell, E. A., & Wood, P. R.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1981-06
- Volume
- 32
- Issue
- 3
- Pages
- 1058-1066
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W1926917528
- Cited by
- 296
- References
- 16
- FWCI
- 35.75
- Type
- journal article
- Language
- en
- Open access
- green
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