The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines
Open accessAbstract
Coronavirus disease 2019 (COVID-19) has swept the world, unlike any other pandemic in the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; disease prognosis is influenced mainly by multi-organ involvement. Acute respiratory distress syndrome, heart failure, renal failure, liver damage, shock and multi-organ failure are strongly associated with morbidity and mortality. The COVID-19 disease pathology is plausibly linked to the hyperinflammatory response of the body characterized by pathological cytokine levels. The term ‘cytokine storm syndrome’ is perhaps one of the critical hallmarks of COVID-19 disease severity. In this review, we highlight prominent cytokine families and their potential role in COVID-19, the type I and II interferons, tumour necrosis factor and members of the Interleukin family. We address various changes in cellular components of the immune response corroborating with changes in cytokine levels while discussing cytokine sources and biological functions. Finally, we discuss in brief potential therapies attempting to modulate the cytokine storm.
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Cites
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Cited by
Pro-Inflammatory and Anti-Inflammatory Interleukins in Infectious Diseases: A Comprehensive Review
Al-Qahtani, A. A., Alhamlan, F. S., & Al-Qahtani, A. A. (2024) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed9010013 · Cited by 291
Metadata
- Authors
- Fara, A., Mitrev, Z., Rosalia, R. A., & Assas, B. M.
- Venue
- Open Biology
- Publisher
- The Royal Society
- Published
- 2020-09
- Volume
- 10
- Issue
- 9
- Pages
- 200160-200160
- ISSN
- 2046-2441 (ISSN-L)
- OpenAlex
- W3087308906
- Cited by
- 369
- References
- 138
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- gold
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- Fara, A., Mitrev, Z., Rosalia, R. A., & Assas, B. M. (2020). Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines. Open Biology. https://doi.org/10.1098/rsob.200160
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
