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Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins
Open accessAbstract
Berberine, an alkaloid from the plant Berberis aristata, which has been known since ancient times as an antidiarrheal medication in India and China, inhibited by approximately 70% the secretory responses of the heat-labile enterotoxins of Vibrio cholerae and Escherichia coli in the rabbit ligated intestinal loop model. The drug was effective when given either before or after enterotoxin binding and when given either intraluminally or parenterally; it did not inhibit the stimulation of adenylate cyclase by cholera enterotoxin and caused no histological damage to intestinal mucosa. Berberine also markedly inhibited the secretory response of E. coli heat-stable enterotoxin in the infant mouse model. Although the mechanism of action of the drug is not yet known, these data provide a rationale for its apparent clinical usefulness in treating acute diarrheal disease.
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Cited by
Alkaloids: An overview of their antibacterial, antibiotic-enhancing and antivirulence activities
Cushnie, T. P. T., Cushnie, B., & Lamb, A. J. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.06.001 · Cited by 894
Berberine as a potential autophagy modulator
Mohammadinejad, R., Ahmadi, Z., Tavakol, S., & Ashrafizadeh, M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28325 · Cited by 132
P-glycoprotein-mediated transport of berberine across Caco-2 cell monolayers
Maeng, H.-J., Yoo, H.-J., Kim, I.-W., Song, I.-S., Chung, S.-J., & Shim, C.-K. (2002) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10268 · Cited by 128
Xu, Y., Wang, Y., Yan, L., Liang, R.-M., Dai, B.-D., Tang, R.-J., Gao, P.-H., & Jiang, Y.-Y. (2009) · Journal of Proteome Research · doi:10.1021/pr9005074 · Cited by 113
Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p
Tong, Y., Zhang, J., Sun, N., Wang, X.-M., Wei, Q., Zhang, Y., Huang, R., Pu, Y., Dai, H., Ren, B., et al. (2021) · Science Bulletin · doi:10.1016/j.scib.2020.12.035 · Cited by 70
Metadata
- Authors
- Sack, R. B., & Froehlich, J. L.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1982-02
- Volume
- 35
- Issue
- 2
- Pages
- 471-475
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2145147747
- Cited by
- 158
- References
- 0
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sack, R. B., & Froehlich, J. L. (1982). Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins. Infection and Immunity. https://doi.org/10.1128/iai.35.2.471-475.1982
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
