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Nanocellulose hyperfine network achieves sustained release of berberine hydrochloride solubilized with β-cyclodextrin for potential anti-infection oral administration

Xiao, L. J., Poudel, A. J., Huang, L., Wang, Y., Abdalla, A. M. E., & Yang, G. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.03.030 · Cited by 34 · see citing works

Nutraceutical approaches to metabolic syndrome

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Effect of ion-pair formation with bile salts on the in vitro cellular transport of berberine

Chae, H.-W., Kim, I., Jin, H., Kim, D., Chung, S., & Shim, C. (2008) · Archives of Pharmacal Research · doi:10.1007/s12272-008-1127-4 · Cited by 31 · see citing works

Biodistribution and pharmacokinetic profile of berberine and its metabolites in hepatocytes

Liu, X., Li, W., Zhang, H., Wang, X., Huang, Y., Li, Y., & Pan, G. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154288 · Cited by 27 · see citing works

A UPLC‐MS/MS method for simultaneous quantitation of three monoterpene glycosides and four alkaloids in rat plasma: application to a comparative pharmacokinetic study of Huo Luo Xiao Ling Dan and single herb extract

Ai, Y., Wu, Y., Wang, F., Ma, W., Bian, Q., Lee, D. Y. W., & Dai, R. (2015) · Journal of Mass Spectrometry · doi:10.1002/jms.3563 · Cited by 26 · see citing works

LC-MS/MS Determination and Pharmacokinetic Study of Dehydrocorydaline in Rat Plasma after Oral Administration of Dehydrocorydaline and Corydalis yanhusuo Extract

Li, Q., Li, K., Sun, H. L., Jin, W., Shi, J.-W., & Shi, Y. (2014) · Molecules · doi:10.3390/molecules191016312 · Cited by 25 · see citing works

Efficacy of Nutraceutical Combination of Monacolin K, Berberine, and Silymarin on Lipid Profile and PCSK9 Plasma Level in a Cohort of Hypercholesterolemic Patients

Formisano, E., Pasta, A., Cremonini, A. L., Favari, E., Ronca, A., Carbone, F., Semino, T., Pierro, F. D., Sukkar, S. G., & Pisciotta, L. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2019.0168 · Cited by 25 · see citing works

Response of Escherichia coli to Prolonged Berberine Exposure

Gökgöz, N. B., Avcı, F. G., Yoneten, K. K., Alaybeyoglu, B., Özkırımlı, E., Sayar, N. A., Kazan, D., & Akbulut, B. S. (2016) · Microbial Drug Resistance · doi:10.1089/mdr.2016.0063 · Cited by 24 · see citing works

Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells

Liu, Y., Zhu, K., Cao, L., Xie, Z., Gu, M., Lu, W. P., Li, J., & Nan, F. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0346-1 · Cited by 24 · see citing works

Approaching strategy to increase the oral bioavailability of berberine, a quaternary ammonium isoquinoline alkaloid: part 2. development of oral dosage formulations

Murakami, T., Bodor, E. T., & Bodor, N. S. (2023) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2023.2203858 · Cited by 23 · see citing works

Requirement for Ergosterol in Berberine Tolerance Underlies Synergism of Fluconazole and Berberine against Fluconazole-Resistant Candida albicans Isolates

Xu, Y., Quan, H., Wang, Y., Zhong, H., Sun, J., Xu, J., Jia, N., & Jiang, Y. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00491 · Cited by 23 · see citing works

Pharmacokinetic interactions between metformin and berberine in rats: Role of oral administration sequences and microbiota

Lyu, Y., Zhang, Y., Yang, M., Lin, L., Yang, X., Cheung, S. C. K., Shaw, P. C., Chan, P. K. S., Kong, A. P. S., & Zuo, Z. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116818 · Cited by 23 · see citing works

Berberine in fish nutrition: Impact on hepatoenteric health, antioxidative and immune status

Wang, L., Sagada, G., Wang, C., Gao, C. Y., Wang, B., Shao, Q., & Yan, Y. (2022) · Frontiers in Marine Science · doi:10.3389/fmars.2022.967748 · Cited by 22 · see citing works

The uptake and transport behavior of berberine in Coptidis Rhizoma extract through rat primary cultured cortical neurons

Wang, X., Xing, D., Wang, W., Fan, L., Su, H. C., & Du, L. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2004.12.050 · Cited by 22 · see citing works

Neuroprotective effect of Berberine Nanoparticles Against Seizures in Pentylenetetrazole Induced Kindling Model of Epileptogenesis: Role of Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms

Saha, L., Kumari, P., Rawat, K., Gautam, V., Sandhu, A., Singh, N., Bhatia, A., Bhattacharya, S., Sinha, V. R., & Chakrabarti, A. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03967-z · Cited by 20 · see citing works

Absorption characteristics of the total alkaloids from Mahonia bealei in an in situ single-pass intestinal perfusion assay

Sun, Y.-H., He, X., Xiao-Lin, Y. A. N. G., Dong, C.-L., Zhang, C.-F., Song, Z., Lu, M., Yang, Z., & Li, P. (2014) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(14)60085-6 · Cited by 20 · see citing works

Improvement of intestinal transport, absorption and anti-diabetic efficacy of berberine by using Gelucire44/14: In vitro, in situ and in vivo studies

Sun, J.-M., Bao, H., Peng, Y., Zhang, H., Sun, Y. N., Qi, J., Zhang, H., & Gao, Y. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.04.014 · Cited by 20 · see citing works

Clinical Drug Interactions with Medicinal Herbs

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Effects of berberine and hwangryunhaedok-tang on oral bioavailability and pharmacokinetics of ciprofloxacin in rats

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Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycaemic control

Sebo, Z. L., Chakrabarty, R. P., Grant, R. A., D’Alessandro, K. B., Koss, A. R., Blum, J. L. E., Davidson, S. M., Reczek, C. R., & Chandel, N. S. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01530-y · Cited by 21 · see citing works

Synthesis of hydrophobically modified berberine derivatives with high anticancer activity through modulation of the MAPK pathway

Wang, L., Yang, X., Li, X., Stoika, R. S., Wang, X., Lin, H., Ma, Y., Wang, R., & Liu, K. (2020) · New Journal of Chemistry · doi:10.1039/d0nj01645d · Cited by 16 · see citing works

Therapeutic Effects of Berberine in Metabolic Diseases and Diabetes Mellitus

Aram, K., Bahari, Z., Elliyeh, M., & Ghasemi, M. (2021) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-021-00159-0 · Cited by 16 · see citing works

Improving the oral bioavailability of berberine: A crystal engineering approach

Surampudi, A. V. S. D., Prasad, S. R., Ramanujam, P., Swain, D., Wadje, B. N., Bharate, S. B., Kamalakannan, U., Kathirvel, M., & Sridhar, B. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.126177 · Cited by 15 · see citing works

New Oral Delivery System to Improve Absorption of Berberine: Likely Interaction of Cationized Chitosan with PG-P Pump.

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A Comprehensive Review Highlighting the Prospects of Phytonutrient Berberine as an Anticancer Agent

Haque, S., Mathkor, D. M., Bhat, S. A., Musayev, A., Khituova, L., Ramniwas, S., Phillips, E., Swamy, N., Kumar, S., Yerer, M. B., et al. (2024) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70073 · Cited by 14 · see citing works

Pharmacological/Biological Effects of Berberine

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Development of Bioadhesive Microspheres for Oral Bioavailability Enhancement of Berberine Hydrochloride

Zhang, Y., & Liu, H. (2016) · International Journal of Polymer Science · doi:10.1155/2016/4235832 · Cited by 13 · see citing works

Involvement of P-glycoprotein and Multidrug Resistance Associated Protein 1 on the Transepithelial Transport of a Mercaptoacetamide-Based Histone-Deacetylase Inhibitor in Caco-2 Cells

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Effect of nonylphenol ethoxylates (NPEs) on barrier functions of epithelial cell membranes: Opening of tight junctions and competitive inhibition of P-gp-mediated efflux

Doo, M.-H., Li, H., Jang, H.-I., Song, I., Chung, S., & Shim, C. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.06.014 · Cited by 13 · see citing works

Pharmacokinetic Differences of Wuji Pill Components in Normal and Chronic Visceral Hypersensitivity Irritable Bowel Syndrome Rats Attributable to Changes in Tight Junction and Transporters

Gong, Z., Yang, Q., Wang, Y., Weng, X., Li, Y., Dong, Y. J., Zhu, X., & Chen, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.948678 · Cited by 12 · see citing works

Enhancement of Berberine Hypoglycemic Activity by Oligomeric Proanthocyanidins

Zhang, H., Wang, X., Wang, T., Chen, K., Wang, H., Jia, Q., & Li, Y. (2018) · Molecules · doi:10.3390/molecules23123318 · Cited by 12 · see citing works

Effectiveness and Safety of Novel Nutraceutical Formulation Added to Ezetimibe in Statin-Intolerant Hypercholesterolemic Subjects with Moderate-to-High Cardiovascular Risk

Mazza, A., Nicoletti, M., Lenti, S., Torin, G., Rigatelli, G., Pellizzato, M., & Fratter, A. (2020) · Journal of Medicinal Food · doi:10.1089/jmf.2020.0019 · Cited by 12 · see citing works

Lipid-based floating multiparticulate delivery system for bioavailability enhancement of berberine hydrochloride

Mishra, R., & Dhole, S. N. (2019) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2019.91105 · Cited by 12 · see citing works

Detoxification mechanisms of ginseng to aconite: A review

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9-O-benzoyl-substituted berberine exerts a triglyceride-lowering effect through AMPK signaling pathway in human hepatoma HepG2 cells

Cao, S., Yu, S., Cheng, L., Yan, J., Zhu, Y., Deng, Y., Qiu, F., & Kang, N. (2018) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2018.09.007 · Cited by 11 · see citing works

Berberine: A Bitter Phytochemical With Diversely Sweet Therapeutic Properties

Sikora, B., Bahadori, M. B., Magg, A. D., Moghadasian, N., & Moghadasian, M. H. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf172 · Cited by 10 · see citing works

The Tetrahydroisoquinoline Scaffold in ABC Transporter Inhibitors that Act as Multidrug Resistance (MDR) Reversers

Teodori, E., Braconi, L., Manetti, D., Romanelli, M. N., & Dei, S. (2022) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026623666221025111528 · Cited by 9 · see citing works

The association between circulatory, local pancreatic PCSK9 and type 2 diabetes mellitus: The effects of antidiabetic drugs on PCSK9

Lu, F., Li, E., & Yang, X. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e19371 · Cited by 8 · see citing works

Unveiling Tetrahydroberberine–1,3,4-Oxadiazole hybrids as potent anticancer agents and MMP-9 inhibitors with comprehensive insights from in silico, in vitro, and ex vivo permeation studies

Shaikh, A. S., Chilvery, S., Patil, S., Mourya, A., Kumar, A., Sharma, A., Ikhe, A. S., Makhal, P. N., Madan, J., Godugu, C., et al. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108791 · Cited by 8 · see citing works

Involvement of CYP3A4 and MDR1 in altered metabolism and transport of indinavir in 1,25(OH)2D3-treated Caco-2 cells

Lee, S., Joo, S.-A., Kim, H., Lee, Y., Chung, S., Chae, Y., & Maeng, H. (2023) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2023.106396 · Cited by 8 · see citing works

Assessment and modulation of phillyrin absorption by P-gp using Caco-2 cells and MDR1-MDCKII cells

Li, Y., Ye, L.-H., Jiang, X., & Peng, C. Y. (2011) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-011-0026-0 · Cited by 8 · see citing works

The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine

Xiao, L., Xue, Y., Zhang, C., Wang, L., Lin, Y., & Pan, G. (2017) · Xenobiotica · doi:10.1080/00498254.2017.1300707 · Cited by 8 · see citing works

Bovine serum albumin modified carbon dots and berberine composite promotes tumor mitochondrial dysfunction and apoptosis

Feng, H., Hong, Y.-J., Zheng, Q.-Q., Ge, J.-M., Cheng, H., Liu, Y., Deng, J., Li, Q., & Qu, S. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.138500 · Cited by 6 · see citing works

The Effect of Streptozotocin and Alloxan on the mRNA Expression of Rat Hepatic Transporters In Vivo

Zhai, T., Wang, J., Sun, L., & Chen, Y. (2014) · AAPS PharmSciTech · doi:10.1208/s12249-014-0262-0 · Cited by 6 · see citing works

Effects of berberine on the transport of P-gp substrates across Caco-2 and L-MDR1 cell monolayers

Klotz, U. E. (2007) · Zhongguo yaolixue tongbao · Cited by 2 · see citing works

Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein

Zhang, X., Qiu, F., Jiang, J. C., Gao, C., & Tan, Y. (2011) · Xenobiotica · doi:10.3109/00498254.2010.529180 · Cited by 109 · see citing works

Effect of Ion-Pair Formation with Bile Salts on the In Vitro Cellular Transport of Berberine

(2007)

Interaction with P-glycoprotein and transport of berberine in Caco-2 cell monolayers Caco-2 세포 단층막에서의 berberine의 수송과 P-glycoprotein과의 상호작용에 관한 연구

맹한주 (2002) · Seoul National University Open Repository (Seoul National University)

The involvement of P-glycoprotein in berberine absorption

Pan, G., Wang, G., Liu, X., Fawcett, J. P., & Xie, Y. (2002) · Pharmacology &amp; Toxicology · doi:10.1034/j.1600-0773.2002.t01-1-910403.x · Cited by 225 · see citing works