The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Colonization of the large bowel by Clostridium difficile in healthy infants: quantitative study
Open accessAbstract
Colonization of the large bowel of healthy infants by Clostridium difficile was studied. Feces were collected from five breast-fed aand five formula-fed infants throughout the first year of life, and levels of C. difficile were quantitated. Three breast-fed and five formula-fed infants were colonized for periods of between 8 and 42 weeks, and another infant harbored the organism only during week 1. Colonization of breast-fed infants commenced before or during weaning, with levels reaching 10(3) to 10(5) organisms per g of wet feces. Colonization of formula-fed infants commenced before solid foods were given, with levels of 10(3) to 10(7) organisms per g of wet feces. Isolates from eight of the babies were shown to produce cytotoxin in vitro. Single fecal specimens from 60 more children aged up to 4 years were also examined, and it was found that the carriage rate of C. difficile fell sharply after 1 year of age, although in the second year it was still higher than in adults. These findings are discussed in relation to the microbial ecology of the large bowel and the paradox that levels of C. difficile in the large bowel of healthy infants are similar to those causing pseudomembranous colitis in patients.
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“multiple studies have shown a decrease in Clostridia colonization of breast-fed infants19, 20 including colonization with Clostridium difficile 21.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [21]
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Cites
Holdeman, L. V., Moore, W. E., & Cato, E. P. (1977) · Cited by 2,988
INTESTINAL FLORA IN NEW-BORN INFANTS
Hall, I. C. (1935) · American journal of diseases of children · doi:10.1001/archpedi.1935.01970020105010 · Cited by 766
CLOSTRIDIUM DIFFICILE AND THE ÆTIOLOGY OF PSEUDOMEMBRANOUS COLITIS
Larson, H. E., Price, A. B., Honour, P., & Borriello, S. P. (1978) · The Lancet · doi:10.1016/s0140-6736(78)90912-1 · Cited by 648
Selective and differential medium for isolation of Clostridium difficile
George, W. L., Sutter, V. L., Citron, D. M., & Finegold, S. M. (1979) · Journal of Clinical Microbiology · doi:10.1128/jcm.9.2.214-219.1979 · Cited by 616
Role of Clostridium difficile in antibiotic-associated pseudomembranous colitis
Bartlett, J. G., Moon, N. I., Chang, T.-W., Taylor, N. S., & Onderdonk, A. B. (1978) · Gastroenterology · doi:10.1016/0016-5085(78)90457-2 · Cited by 507
Antibiotic-Associated Pseudomembranous Colitis
Bartlett, J. G. (1979) · Clinical Infectious Diseases · doi:10.1093/clinids/1.3.530 · Cited by 243
Clinical and laboratory observations in Clostridium difficile colitis
Bartlett, J. G., Taylor, N. S., Chang, T., & Dzink, J. L. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.11.2521 · Cited by 161
George, W. L., Sutter, V. L., & Finegold, S. M. (1978) · Current Microbiology · doi:10.1007/bf02601709 · Cited by 123
Pseudomembranous enterocolitis (antibiotic-related colitis).
Bartlett, J. G., & Sl, G. (1977) · PubMed · Cited by 102
Transport and Storage of Faeces for Bacteriological Examination
Crowther, J. S. (1971) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1971.tb02307.x · Cited by 100
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Entis, P. (2014) · ASM Press eBooks · doi:10.1128/9781555816186.app1
Tilkorn, F. K. M. T. (2022) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-156
Chambers, C. J. (2013) · The University of Bath Online Publications Store (The University of Bath)
Diagnostik und Epidemiologie der Clostridium difficile-Infektion
Ruckdeschel, G., Lob, S. H., & Schwarzenböck, A. (1996) · Springer eBooks · doi:10.1007/978-3-642-80327-7_4
Metadata
- Authors
- Stark, P. L., Lee, A., & Parsonage, B. D.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1982-03
- Volume
- 35
- Issue
- 3
- Pages
- 895-899
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC351131
- OpenAlex
- W2102086074
- Cited by
- 104
- References
- 24
- Citations by year
- 2024: 2 · 2022: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 5
- FWCI
- 10.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- Clostridium difficile, intestinal colonization, infants, breastfeeding, bottle feeding, weaning, cytotoxin production, carriage rate, pseudomembranous colitis, fecal carriage
- MeSH terms
- Bacterial Toxins, Clostridium, Cytotoxins, Feces, Humans, Infant, Infant, Newborn, Intestine, Large, Prospective Studies, Time Factors
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