The DOI matches its Crossref record; 25 of the 26 references it cites were found in a registry or an index.
Natural variation of poliovirus neutralization epitopes
Open accessAbstract
Poliovirus-neutralizing monoclonal antibodies were prepared against type 1, type 2, and type 3 wild laboratory (Mahoney, MEF1, and Saukett) and Sabin vaccine strains. Fifty-five poliovirus laboratory strains and field isolates were assayed by neutralization index test with a panel of homotypic monoclonal antibodies. A total of 27 monoclonal antibodies were used. Two categories of neutralization epitopes were found, i.e., cross-reacting (K), which is present on almost all strains of the same serotype, and strain-specific (V, variable), either wild (VW) or Sabin (VS). Several distinct neutralization epitopes were defined for each of the three poliovirus serotypes in almost every category. The study of antigenic variation of the Sabin type 1 vaccine virus during replication in human intestine showed that the VS neutralization epitope may be lost and even replaced by the VW epitopes of the parental Mahoney virus. A late isolate from a vaccine-fed infant recovered the complete neutralization epitope pattern of the Mahoney strain. Upon in vivo virus replication, a different kind of antigenic variation was also detected in which an epitope lost its function in virus neutralization but kept its antigenic conformation unaltered. Neutralization epitope analysis demonstrated that the presence of VS epitopes on a field isolate suggests the Sabin origin of the strain when the isolate displays the same epitope pattern as the original Sabin virus, or confirms it when the VS epitope(s) is mutually exclusive of VW epitopes. The lack of VS epitopes on a field isolate does not rule out its being of Sabin origin.
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Kessler, S. (1975) · The Journal of Immunology · doi:10.4049/jimmunol.115.6.1617 · Cited by 2,887
A better cell line for making hybridomas secreting specific antibodies
Shulman, M. J., Wilde, C. D., & Köhler, G. (1978) · Nature · doi:10.1038/276269a0 · Cited by 1,598
History of Sabin attenuated poliovirus oral live vaccine strains
Sabin, A. B., & Boulger, L. R. (1973) · Journal of Biological Standardization · doi:10.1016/0092-1157(73)90048-6 · Cited by 316
Matthews, R. E. F. (1982) · Intervirology · Cited by 276
Molecular variation of type 1 vaccine-related and wild polioviruses during replication in humans
Nottay, B. K., Kew, O. M., Hatch, M. H., Heyward, J. T., & Obijeski, J. F. (1981) · Virology · doi:10.1016/0042-6822(81)90448-7 · Cited by 190
Antigenic analysis of polioviruses by kinetic studies of serum neutralization
McBride, W. D. (1959) · Virology · doi:10.1016/0042-6822(59)90176-x · Cited by 165
Multiple Genetic Changes Can Occur in the Oral Poliovaccines upon Replication in Humans
Kew, O. M., Nottay, B. K., Hatch, M. H., Nakano, J. H., & Obijeski, J. F. (1981) · Journal of General Virology · doi:10.1099/0022-1317-56-2-337 · Cited by 149
Emini, E. A., Jameson, B. A., Lewis, A., Larsen, G. R., & Wimmer, E. (1982) · Journal of Virology · doi:10.1128/jvi.43.3.997-1005.1982 · Cited by 138
Characterization of type 1 poliovirus by electrophoretic analysis
Mandel, B. (1971) · Virology · doi:10.1016/0042-6822(71)90369-2 · Cited by 122
Intratypic Serodifferentiation of Poliomyelitis Virus Strains by Strain-Specific Antisera
van Weze, A. L., & Hazendonk, A. G. (1979) · Intervirology · doi:10.1159/000149005 · Cited by 106 · cited 2×
“upon replication in vaccinees has so far been demonstrated by using strain-specific polyclonal antibodies (22, 27).”
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Research works printed but not linked: 1
- Osterhaus A. D., van Wezel A. L., van Steenis G., Hazendonk A. G., Drost G. Production and potential use of monoclonal antibodies against polio viruses. Dev Biol Stand. 1981;50:221–228. [PubMed] [Google Scholar]
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Sorted by citations
Three-Dimensional Structure of Poliovirus at 2.9 Å Resolution
Hogle, J. M., Chow, M., & Filman, D. J. (1985) · Science · doi:10.1126/science.2994218 · Cited by 1,267
VACCINE-DERIVED POLIOVIRUSES AND THE ENDGAME STRATEGY FOR GLOBAL POLIO ERADICATION
Kew, O. M., Sutter, R. W., de Gourville, E. M., Dowdle, W. R., & Pallansch, M. A. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123625 · Cited by 703
Strebel, P. M., Sutter, R. W., Cochi, S. L., Biellik, R., Brink, E. W., Kew, O. M., Pallansch, M. A., Orenstein, W. A., & Hinman, A. R. (1992) · Clinical Infectious Diseases · doi:10.1093/clinids/14.2.568 · Cited by 337
Geographic distribution of wild poliovirus type 1 genotypes
Rico-Hesse, R., Pallansch, M. A., Nottay, B. K., & Kew, O. M. (1987) · Virology · doi:10.1016/0042-6822(87)90001-8 · Cited by 327
Antibody recognition of picornaviruses and escape from neutralization: a structural view
Mateu, M. G. (1995) · Virus Research · doi:10.1016/0168-1702(95)00048-u · Cited by 282
Metadata
- Authors
- Crainic, R., Couillin, P., Blondel, B., Cabau, N., Boué, A., & Horodniceanu, F.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1983-09
- Volume
- 41
- Issue
- 3
- Pages
- 1217-1225
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC264629
- OpenAlex
- W1893449782
- Cited by
- 110
- References
- 26
- Citations by year
- 2026: 1 · 2023: 2 · 2019: 1 · 2018: 2 · 2015: 3 · 2014: 3 · 2012: 2
- FWCI
- 7.66
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- poliovirus, neutralizing epitopes, antigenic variation, Sabin vaccine strains, Mahoney strain, neutralizing monoclonal antibodies, cross-reactive epitopes, strain-specific epitopes, oral polio vaccine, human intestine
- MeSH terms
- Antibodies, Monoclonal, Epitopes, Antigens, Viral, Cross Reactions, Humans, Hybridomas, Neutralization Tests, Serotyping, Virus Cultivation, Poliovirus
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