CoChat
Sign Up
Cited by 110Viral Infections and Immunology ResearchVirology and Viral DiseasesEvolution and Genetic Dynamics

The DOI matches its Crossref record; 25 of the 26 references it cites were found in a registry or an index.

Natural variation of poliovirus neutralization epitopes

Open access
Crainic, R, Couillin, P, Blondel, B, Cabau, N, Boué, A, Horodniceanu, F·1983·Infection and Immunity
DOI 10.1128/iai.41.3.1217-1225.1983PMC PMC264629
Open this paper in CoChat — free account

Abstract

Poliovirus-neutralizing monoclonal antibodies were prepared against type 1, type 2, and type 3 wild laboratory (Mahoney, MEF1, and Saukett) and Sabin vaccine strains. Fifty-five poliovirus laboratory strains and field isolates were assayed by neutralization index test with a panel of homotypic monoclonal antibodies. A total of 27 monoclonal antibodies were used. Two categories of neutralization epitopes were found, i.e., cross-reacting (K), which is present on almost all strains of the same serotype, and strain-specific (V, variable), either wild (VW) or Sabin (VS). Several distinct neutralization epitopes were defined for each of the three poliovirus serotypes in almost every category. The study of antigenic variation of the Sabin type 1 vaccine virus during replication in human intestine showed that the VS neutralization epitope may be lost and even replaced by the VW epitopes of the parental Mahoney virus. A late isolate from a vaccine-fed infant recovered the complete neutralization epitope pattern of the Mahoney strain. Upon in vivo virus replication, a different kind of antigenic variation was also detected in which an epitope lost its function in virus neutralization but kept its antigenic conformation unaltered. Neutralization epitope analysis demonstrated that the presence of VS epitopes on a field isolate suggests the Sabin origin of the strain when the isolate displays the same epitope pattern as the original Sabin virus, or confirms it when the VS epitope(s) is mutually exclusive of VW epitopes. The lack of VS epitopes on a field isolate does not rule out its being of Sabin origin.

Overview

Integrity signals

Registry

Crossref · 10.1128/iai.41.3.1217-1225.1983

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Citations

Cites

Show all 26 references

Research works printed but not linked: 1

  1. Osterhaus A. D., van Wezel A. L., van Steenis G., Hazendonk A. G., Drost G. Production and potential use of monoclonal antibodies against polio viruses. Dev Biol Stand. 1981;50:221–228. [PubMed] [Google Scholar]

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Crainic, R., Couillin, P., Blondel, B., Cabau, N., Boué, A., & Horodniceanu, F.
Venue
Infection and Immunity
Publisher
American Society for Microbiology
Published
1983-09
Volume
41
Issue
3
Pages
1217-1225
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
DOI
10.1128/iai.41.3.1217-1225.1983
PMC
PMC264629
OpenAlex
W1893449782
Cited by
110
References
26
Citations by year
2026: 1 · 2023: 2 · 2019: 1 · 2018: 2 · 2015: 3 · 2014: 3 · 2012: 2
FWCI
7.66
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Infection and Immunity (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords
poliovirus, neutralizing epitopes, antigenic variation, Sabin vaccine strains, Mahoney strain, neutralizing monoclonal antibodies, cross-reactive epitopes, strain-specific epitopes, oral polio vaccine, human intestine
MeSH terms
Antibodies, Monoclonal, Epitopes, Antigens, Viral, Cross Reactions, Humans, Hybridomas, Neutralization Tests, Serotyping, Virus Cultivation, Poliovirus

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review