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Purification and antibacterial activity of antimicrobial peptides of rabbit granulocytes
Open accessAbstract
Six antimicrobial peptides, corresponding to the family of "lysosomal cationic proteins" described previously by Zeya and Spitznagel (H. I. Zeya and J. K. Spitznagel, J. Bacteriol. 91:750-754, 1966; H. I. Zeya and J. K. Spitznagel, J. Bacteriol. 91:755-762, 1966), were purified from rabbit peritoneal granulocytes by preparative acrylamide gel electrophoresis and reversed-phase high-pressure liquid chromatography. Each of the peptides was of low molecular weight (ca. 4,000) as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The two most cationic peptides, NP-1 and NP-2, were active against a broad spectrum of gram-positive and gram-negative bacteria. The remaining four peptides, NP-3A, NP-3B, NP-4, and NP-5, had more selective antibacterial activity. None of the peptides was active against Bordetella bronchiseptica, a common pathogen of domestic rabbits. Antibacterial activity was best expressed at near neutral pH under conditions of low ionic strength.
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Citations
Cited by
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Agents that increase the permeability of the outer membrane
Vaara, M. (1992) · Microbiological Reviews · doi:10.1128/mr.56.3.395-411.1992 · Cited by 1,879
Defensins: Antimicrobial and Cytotoxic Peptides of Mammalian Cells
Lehrer, R. I., Lichtenstein, A. K., & Ganz, T. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.000541 · Cited by 991
Self-citationYang, D., Biragyn, A., Hoover, D. M., Lubkowski, J., & Oppenheim, J. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104603 · Cited by 572
Kagan, B. L., Selsted, M. E., Ganz, T., & Lehrer, R. I. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.210 · Cited by 532
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Metadata
- Authors
- Selsted, M. E., Szklarek, D., & Lehrer, R. I.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1984-07
- Volume
- 45
- Issue
- 1
- Pages
- 150-154
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2286897117
- Cited by
- 307
- References
- 0
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Selsted, M. E., Szklarek, D., & Lehrer, R. I. (1984). Purification and antibacterial activity of antimicrobial peptides of rabbit granulocytes. Infection and Immunity. https://doi.org/10.1128/iai.45.1.150-154.1984
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