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Hemolysin of Streptococcus faecalis subspecies zymogenes contributes to virulence in mice
Open accessAbstract
The conjugative plasmid pAD1 (56.7 kilobases) in Streptococcus faecalis confers hemolysin-bacteriocin (Hly-Bcn) expression and a mating response to the sex pheromone cAD1 excreted by recipient cells. We examined the contribution of hemolysin to pathogenicity in intraperitoneally infected mice by using Tn916 and Tn917 insertion mutants altered in hemolysin expression. Strains exhibiting the normal hemolysin phenotype were significantly more virulent than the nonhemolytic insertion mutants. A mutant plasmid with an increased copy number which gave rise to a larger-than-normal zone of hemolysis on blood agar rendered host strains more virulent than the wild-type streptococci in mice.
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Citations
Cited by
The rise of the Enterococcus: beyond vancomycin resistance
Arias, C. A., & Murray, B. E. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2761 · Cited by 1,776
The role and application of enterococci in food and health
Foulquié Moreno, M. R., Sarantinopoulos, P., Tsakalidou, E., & De Vuyst, L. (2006) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2005.06.026 · Cited by 1,080
Enterococci as probiotics and their implications in food safety
Franz, C. M. A. P., Huch, M., Abriouel, H., Holzapfel, W., & Gálvez, A. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.08.014 · Cited by 788
Fiore, E., Van Tyne, D., & Gilmore, M. S. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0053-2018 · Cited by 503
Diversity of enterococcal bacteriocins and their grouping in a new classification scheme
Franz, C. M. A. P., Van Belkum, M. J., Holzapfel, W. H., Abriouel, H., & Gálvez, A. (2007) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2007.00064.x · Cited by 444
Metadata
- Authors
- Ike, Y., Hashimoto, H., & Clewell, D. B.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1984-08
- Volume
- 45
- Issue
- 2
- Pages
- 528-530
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2141409425
- Cited by
- 240
- References
- 0
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ike, Y., Hashimoto, H., & Clewell, D. B. (1984). Hemolysin of Streptococcus faecalis subspecies zymogenes contributes to virulence in mice. Infection and Immunity. https://doi.org/10.1128/iai.45.2.528-530.1984
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
