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Cited by 152Oral microbiology and periodontitis researchBacterial biofilms and quorum sensingBiochemical and Structural Characterization

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Inhibition of coaggregation between Fusobacterium nucleatum and Porphyromonas (Bacteroides) gingivalis by lactose and related sugars

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Kolenbrander, P E, Andersen, R N·1989·Infection and Immunity
DOI 10.1128/iai.57.10.3204-3209.1989PMC PMC260790
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Abstract

The coaggregation of Fusobacterium nucleatum PK1594 and Porphyromonas (Bacteroides) gingivalis PK1924 was inhibited equally well by lactose, N-acetyl-D-galactosamine, and D-galactose, which caused 50% inhibition of coaggregation at 2 mM sugar concentration. Other sugars such as D-galactosamine, D-fucose (6-deoxy-D-galactose), and alpha-methyl- and beta-methyl-D-galactosides also inhibited coaggregation. Sugar specificity was apparent, since neither L-fucose, L-rhamnose, N-acetyl-D-glucosamine, nor N-acetylneuraminic acid was an inhibitor. Protease treatment of the fusobacterium completely abolished coaggregation, whereas it had no effect on the coaggregating activity of the porphyromonad. Although numerous lactose-inhibitable coaggregating pairs are known to occur among gram-positive bacteria, this report and the accompanying survey (P. E. Kolenbrander, R. N. Andersen, and L. V. H. Moore, Infect. Immun. 57:3194-3203, 1989) are the first studies demonstrating the extensive nature of this type of interaction between gram-negative human oral bacteria. The significance of galactoside-inhibitable coaggregations between these two potential periodontal pathogens is discussed.

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Crossref · 10.1128/iai.57.10.3204-3209.1989

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Metadata

Authors
Kolenbrander, P. E., & Andersen, R. N.
Affiliations
National Institutes of Health (US)
Venue
Infection and Immunity
Publisher
American Society for Microbiology
Published
1989-10
Volume
57
Issue
10
Pages
3204-3209
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
DOI
10.1128/iai.57.10.3204-3209.1989
PMC
PMC260790
OpenAlex
W1868918083
Cited by
152
References
39
Citations by year
2026: 1 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 4 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 9
FWCI
8.22
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Infection and Immunity (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
Keywords
bacterial coaggregation, Fusobacterium nucleatum, Porphyromonas gingivalis, lactose, galactosides, N-acetylgalactosamine, galactose, sugar specificity, periodontal pathogens, oral bacteria, protease sensitivity, Gram-negative bacteria, bacterial adhesion
MeSH terms
Acetylgalactosamine, Bacterial Adhesion, Bacteroides, Fusobacterium, Galactose, Kinetics, Lactose

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