Cited by 152Oral microbiology and periodontitis researchBacterial biofilms and quorum sensingBiochemical and Structural Characterization

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Inhibition of coaggregation between Fusobacterium nucleatum and Porphyromonas (Bacteroides) gingivalis by lactose and related sugars

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Kolenbrander, P E, Andersen, R N·1989·Infection and Immunity

DOI 10.1128/iai.57.10.3204-3209.1989PMC PMC260790

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Abstract

The coaggregation of Fusobacterium nucleatum PK1594 and Porphyromonas (Bacteroides) gingivalis PK1924 was inhibited equally well by lactose, N-acetyl-D-galactosamine, and D-galactose, which caused 50% inhibition of coaggregation at 2 mM sugar concentration. Other sugars such as D-galactosamine, D-fucose (6-deoxy-D-galactose), and alpha-methyl- and beta-methyl-D-galactosides also inhibited coaggregation. Sugar specificity was apparent, since neither L-fucose, L-rhamnose, N-acetyl-D-glucosamine, nor N-acetylneuraminic acid was an inhibitor. Protease treatment of the fusobacterium completely abolished coaggregation, whereas it had no effect on the coaggregating activity of the porphyromonad. Although numerous lactose-inhibitable coaggregating pairs are known to occur among gram-positive bacteria, this report and the accompanying survey (P. E. Kolenbrander, R. N. Andersen, and L. V. H. Moore, Infect. Immun. 57:3194-3203, 1989) are the first studies demonstrating the extensive nature of this type of interaction between gram-negative human oral bacteria. The significance of galactoside-inhibitable coaggregations between these two potential periodontal pathogens is discussed.

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Background
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Authors: Kolenbrander, P. E., & Andersen, R. N.
Affiliations: National Institutes of Health (US)
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 1989-10
Volume: 57
Issue: 10
Pages: 3204-3209
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.57.10.3204-3209.1989
PMC: PMC260790
OpenAlex: W1868918083
Cited by: 152
References: 39
Citations by year: 2026: 1 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 4 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 9
FWCI: 8.22
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
Keywords: bacterial coaggregation, Fusobacterium nucleatum, Porphyromonas gingivalis, lactose, galactosides, N-acetylgalactosamine, galactose, sugar specificity, periodontal pathogens, oral bacteria, protease sensitivity, Gram-negative bacteria, bacterial adhesion
MeSH terms: Acetylgalactosamine, Bacterial Adhesion, Bacteroides, Fusobacterium, Galactose, Kinetics, Lactose

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Inhibition of coaggregation between Fusobacterium nucleatum and Porphyromonas (Bacteroides) gingivalis by lactose and related sugars

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