The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Inhibition of coaggregation between Fusobacterium nucleatum and Porphyromonas (Bacteroides) gingivalis by lactose and related sugars
Open accessAbstract
The coaggregation of Fusobacterium nucleatum PK1594 and Porphyromonas (Bacteroides) gingivalis PK1924 was inhibited equally well by lactose, N-acetyl-D-galactosamine, and D-galactose, which caused 50% inhibition of coaggregation at 2 mM sugar concentration. Other sugars such as D-galactosamine, D-fucose (6-deoxy-D-galactose), and alpha-methyl- and beta-methyl-D-galactosides also inhibited coaggregation. Sugar specificity was apparent, since neither L-fucose, L-rhamnose, N-acetyl-D-glucosamine, nor N-acetylneuraminic acid was an inhibitor. Protease treatment of the fusobacterium completely abolished coaggregation, whereas it had no effect on the coaggregating activity of the porphyromonad. Although numerous lactose-inhibitable coaggregating pairs are known to occur among gram-positive bacteria, this report and the accompanying survey (P. E. Kolenbrander, R. N. Andersen, and L. V. H. Moore, Infect. Immun. 57:3194-3203, 1989) are the first studies demonstrating the extensive nature of this type of interaction between gram-negative human oral bacteria. The significance of galactoside-inhibitable coaggregations between these two potential periodontal pathogens is discussed.
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Metadata
- Authors
- Kolenbrander, P. E., & Andersen, R. N.
- Affiliations
- National Institutes of Health (US)
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1989-10
- Volume
- 57
- Issue
- 10
- Pages
- 3204-3209
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC260790
- OpenAlex
- W1868918083
- Cited by
- 152
- References
- 39
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 4 · 2019: 2 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 9
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
- Keywords
- bacterial coaggregation, Fusobacterium nucleatum, Porphyromonas gingivalis, lactose, galactosides, N-acetylgalactosamine, galactose, sugar specificity, periodontal pathogens, oral bacteria, protease sensitivity, Gram-negative bacteria, bacterial adhesion
- MeSH terms
- Acetylgalactosamine, Bacterial Adhesion, Bacteroides, Fusobacterium, Galactose, Kinetics, Lactose
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