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Anaerobiosis, type 1 fimbriae, and growth phase are factors that affect invasion of HEp-2 cells by Salmonella typhimurium
Open accessAbstract
The invasion of HEp-2 cells by Salmonella typhimurium was studied under various conditions. Anaerobiosis was shown to markedly affect the internalization of bacterial cells by HEp-2 cells. Anaerobically grown bacteria incubated with HEp-2 cells under anaerobic conditions markedly stimulated the rate of invasion. Anaerobiosis may therefore be a controlling factor in the invasion process. Cells obtained during the logarithmic phase of growth invaded at much higher rates than cells obtained during the stationary phase of growth. The presence of mannose-sensitive type 1 fimbriae on the bacterial surface also promoted invasion, and these fimbriae appear to play a role as an accessory virulence factor.
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Citations
Cited by
Environmental signals controlling expression of virulence determinants in bacteria
Mekalanos, J. J. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.1.1-7.1992 · Cited by 788
Molecular genetic bases of Salmonella entry into host cells
Galán, J. E. (1996) · Molecular Microbiology · doi:10.1111/j.1365-2958.1996.tb02615.x · Cited by 435
Molecular Basis of the Interaction of Salmonella with the Intestinal Mucosa
Darwin, K. H., & Miller, V. L. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.3.405 · Cited by 435
Evolution of Host Adaptation in Salmonella enterica
Bäumler, A. J., Tsolis, R. M., Ficht, T. A., & Adams, L. G. (1998) · Infection and Immunity · doi:10.1128/iai.66.10.4579-4587.1998 · Cited by 367
Measurement of invasion by gentamicin resistance
Elsinghorst, E. A. (1994) · Methods in Enzymology · doi:10.1016/0076-6879(94)36030-8 · Cited by 342
Metadata
- Authors
- Ernst, R. K., Dombroski, D. M., & Merrick, J. M.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1990-06
- Volume
- 58
- Issue
- 6
- Pages
- 2014-2016
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W1910231172
- Cited by
- 211
- References
- 0
- FWCI
- 41.23
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Anaerobiosis, type 1 fimbriae, and growth phase are factors that affect invasion of HEp-2 cells by Salmonella typhimurium. https://app.cochat.ai/papers/10.1128/iai.58.6.2014-2016.1990
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- Ernst, R. K., Dombroski, D. M., & Merrick, J. M. (1990). Anaerobiosis, type 1 fimbriae, and growth phase are factors that affect invasion of HEp-2 cells by Salmonella typhimurium. Infection and Immunity. https://doi.org/10.1128/iai.58.6.2014-2016.1990
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