Apathogenic, intestinal, segmented, filamentous bacteria stimulate the mucosal immune system of mice
Open accessAbstract
Segmented filamentous bacteria (SFBs) are apathogenic autochthonous bacteria in the murine small intestine that preferentially attach to Peyer's patch epithelium. SFBs have never been cultured in vitro. We have studied the effects of SFBs on the immune system of the host. Mice monoassociated with SFBs were compared with germ-free mice and with mice without SFBs but with a specific-pathogen-free (SPF) gut flora. SFBs versus no microbial flora raised the number of lymphoid cells in the lamina propria of the ileal and cecal mucosa, raised the number of immunoglobulin A (IgA)-secreting cells in the intestinal mucosa, produced elevated IgA titers in serum and intestinal secretions, and enhanced the concanavalin A-induced proliferative responses of mesenteric lymph node cells. The SPF flora had effects similar to but less pronounced than those mediated by SFBs. The results indicate that SFBs stimulate the mucosal immune system to a greater extent than do other autochthonous gut bacteria.
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Segmented filamentous bacteria are critical promoters of intestinal mucosal IgA production and Th17 cell induction.
“segmented filamentous bacteria are critical promoters of intestinal mucosal IgA production (39, 40)and Th17 cell induction (41, 42)”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [39]
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- Authors
- Klaasen, H. L., Van der Heijden, P. J., Stok, W., Poelma, F. G., Koopman, J. P., Van den Brink, M. E., Bakker, M. H., Eling, W. M., & Beynen, A. C.
- Affiliations
- Radboud University Nijmegen (NL)
- Central Animal Laboratory, Catholic University, Nijmegen, The Netherlands.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1993-01
- Volume
- 61
- Issue
- 1
- Pages
- 303-306
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC302719
- OpenAlex
- W1940354221
- Cited by
- 231
- References
- 17
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 10 · 2020: 10 · 2019: 12 · 2018: 16 · 2017: 10 · 2016: 14 · 2015: 11 · 2014: 8 · 2013: 16 · 2012: 9
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- segmented filamentous bacteria, mucosal immunity, Peyer's patches, gut microbiota, germ-free mice, immunoglobulin A, lamina propria lymphocytes, mesenteric lymph nodes, concanavalin A response, ileum, cecum
- MeSH terms
- Animals, Bacterial Infections, Cecum, Feces, Germ-Free Life, Immunoglobulin A, Intestinal Mucosa, Intestine, Small, Lymphocyte Activation, Spleen, T-Lymphocytes, Mice
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