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Cited by 537

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Porphyromonas gingivalis invasion of gingival epithelial cells

Open access
Lamont, R J, Chan, A, Belton, C M, Izutsu, K T, Vasel, D, Weinberg, A·1995·Infection and Immunity
DOI 10.1128/iai.63.10.3878-3885.1995
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Abstract

Porphyromonas gingivalis, a periodontal pathogen, can invade primary cultures of gingival epithelial cells. Optimal invasion occurred at a relatively low multiplicity of infection (i.e., 100) and demonstrated saturation at a higher multiplicity of infection. Following the lag phase, during which bacteria invaded poorly, invasion was independent of growth phase. P. gingivalis was capable of replicating within the epithelial cells. Invasion was an active process requiring both bacterial and epithelial cell energy production. Invasion was sensitive to inhibitors of microfilaments and microtubules, demonstrating that epithelial cell cytoskeletal rearrangements are involved in bacterial entry. P. gingivalis, but not epithelial cell, protein synthesis was necessary for invasion. Invasion within the epithelial cells was not blocked by inhibitors of protein kinase activity. Invasion was inhibited by protease inhibitors, suggesting that P. gingivalis proteases may be involved in the invasion process. Low-passage clinical isolates of P. gingivalis invaded with higher efficiency than the type strain. Serum inhibited invasion of the type strain but had no effect on the invasion of a clinical isolate. Invasion of gingival epithelial cells by P. gingivalis may contribute to the pathology of periodontal diseases.

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Metadata

Authors
Lamont, R. J., Chan, A., Belton, C. M., Izutsu, K. T., Vasel, D., & Weinberg, A.
Venue
Infection and Immunity
Publisher
American Society for Microbiology
Published
1995-10
Volume
63
Issue
10
Pages
3878-3885
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
DOI
10.1128/iai.63.10.3878-3885.1995
OpenAlex
W2167491944
Cited by
537
References
34
FWCI
13.75
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Porphyromonas gingivalis invasion of gingival epithelial cells. https://app.cochat.ai/papers/10.1128/iai.63.10.3878-3885.1995
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Lamont, R. J., Chan, A., Belton, C. M., Izutsu, K. T., Vasel, D., & Weinberg, A. (1995). Porphyromonas gingivalis invasion of gingival epithelial cells. Infection and Immunity. https://doi.org/10.1128/iai.63.10.3878-3885.1995

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.