The DOI matches its Crossref record.
T-cell cytokine responses in human infection with Mycobacterium tuberculosis
Open accessAbstract
Compared with healthy tuberculin reactors, Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells from tuberculosis patients had diminished production and mRNA expression of the Th1 cytokines gamma interferon and interleukin 2 (IL-2), with no change in production and mRNA expression for the Th2 cytokines IL-4, IL-10, and IL-13. These results were confirmed by evaluation of T cells and CD4+ cells. At the level of systemic T cells, development of tuberculosis is associated with diminished Th1 but not enhanced Th2 responses.
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Citations
Cited by
Interferon-γ assays in the immunodiagnosis of tuberculosis: a systematic review
Pai, M., Riley, L. W., & Colford, J. M. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)01206-x · Cited by 913
Regulatory T Cells Are Expanded in Blood and Disease Sites in Patients with Tuberculosis
Guyot-Revol, V., Innes, J. A., Hackforth, S., Hinks, T., & Lalvani, A. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200508-1294oc · Cited by 444
The Host Immune Response to Tuberculosis
SCHLUGER, N. W., & ROM, W. N. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.3.9708002 · Cited by 428
Effects of cytokines on mycobacterial phagosome maturation
Via, L. E., Fratti, R. A., McFalone, M., Pagán-Ramos, E., Deretic, D., & Deretic1, V. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.7.897 · Cited by 356
Pathan, A. A., Wilkinson, K. A., Klenerman, P., McShane, H., Davidson, R. N., Pasvol, G., Hill, A. V. S., & Lalvani, A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.5217 · Cited by 351
Metadata
- Authors
- Zhang, M., Lin, Y., Iyer, D. V., Gong, J., Abrams, J. S., & Barnes, P. F.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1995-08
- Volume
- 63
- Issue
- 8
- Pages
- 3231-3234
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W1819607739
- Cited by
- 285
- References
- 0
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, M., Lin, Y., Iyer, D. V., Gong, J., Abrams, J. S., & Barnes, P. F. (1995). T-cell cytokine responses in human infection with Mycobacterium tuberculosis. Infection and Immunity. https://doi.org/10.1128/iai.63.8.3231-3234.1995
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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