The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Direct Ex Vivo Analysis of Antigen-Specific IFN-γ-Secreting CD4 T Cells in Mycobacterium tuberculosis -Infected Individuals: Associations with Clinical Disease State and Effect of Treatment
Open accessAbstract
The wide spectrum of clinical outcomes following infection with Mycobacterium tuberculosis is largely determined by the host immune response; therefore, we studied several clinically defined groups of individuals (n = 120) that differ in their ability to contain the bacillus. To quantitate M. tuberculosis-specific T cells directly ex vivo, we enumerated IFN-γ-secreting CD4 T cells specific for ESAT-6, a secreted Ag that is highly specific for M. tuberculosis, and a target of protective immune responses in animal models. We found that frequencies of circulating ESAT-6 peptide-specific IFN-γ-secreting CD4 T cells were higher in latently infected healthy contacts and subjects with minimal disease and low bacterial burdens than in patients with culture-positive active pulmonary tuberculosis (p = 0.009 and p = 0.002, respectively). Importantly, the frequency of these Ag-specific CD4 T cells fell progressively in all groups with treatment (p = 0.005), suggesting that the lower responses in patients with more extensive disease were not due to tuberculosis-induced immune suppression. This population of M. tuberculosis Ag-specific Th1-type CD4 T cells appears to correlate with clinical phenotype and declines during successful therapy; these features are consistent with a role for these T cells in the containment of M. tuberculosis in vivo. Such findings may assist in the design and evaluation of novel tuberculosis vaccine candidates.
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Cites
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Cited by
Menzies, D., Pai, M., & Comstock, G. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-5-200703060-00006 · Cited by 984
Interferon-γ assays in the immunodiagnosis of tuberculosis: a systematic review
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A systematic review of rapid diagnostic tests for the detection of tuberculosis infection
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Self-citationSpecific Detection of Tuberculosis Infection: An Interferon-γ–based Assay Using New Antigens
Mori, T., Sakatani, M., Yamagishi, F., Takashima, T., Kawabe, Y., Nagao, K., Shigeto, E., Harada, N., Mitarai, S., Okada, M., et al. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200402-179oc · Cited by 657
Immunology of Mycobacterium tuberculosis Infections
Sia, J. K., & Rengarajan, J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0022-2018 · Cited by 312
Metadata
- Authors
- Pathan, A. A., Wilkinson, K. A., Klenerman, P., McShane, H., Davidson, R. N., Pasvol, G., Hill, A. V. S., & Lalvani, A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-11-01
- Volume
- 167
- Issue
- 9
- Pages
- 5217-5225
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2111728452
- Cited by
- 351
- References
- 47
- FWCI
- 9.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Direct Ex Vivo Analysis of Antigen-Specific IFN-γ-Secreting CD4 T Cells in Mycobacterium tuberculosis -Infected Individuals: Associations with Clinical Disease State and Effect of Treatment. https://app.cochat.ai/papers/10.4049/jimmunol.167.9.5217
- The paper
- Pathan, A. A., Wilkinson, K. A., Klenerman, P., McShane, H., Davidson, R. N., Pasvol, G., Hill, A. V. S., & Lalvani, A. (2001). Direct Ex Vivo Analysis of Antigen-Specific IFN-γ-Secreting CD4 T Cells in Mycobacterium tuberculosis -Infected Individuals: Associations with Clinical Disease State and Effect of Treatment. The Journal of Immunology. https://doi.org/10.4049/jimmunol.167.9.5217
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
