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Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection
Open accessAbstract
We sought to identify which Pseudomonas aeruginosa products are involved initiating respiratory tract infection. Defined mutants derived from strain PAO i.e., PAOR1 (lasR),PAO-pmm (algC) (an LPS mutant), and AK1152 (which is Fla- and lacks functional pili), were significantly less virulent than PAO1 in a BALBc/ByJ neonatal mouse model of infection as measured by their abilities to cause acute pneumonia, bacteremia, and death. All three mutants were also less adherent to epithelial cells in an in vitro binding assay. PAOR1 and AK1152 were less able to elicit epithelial production of interleukin-8 than PAO1. LasR was found to be required for the optimal expression of neuraminidase under conditions of increased osmolarity, as might be present in certain pathological conditions. PAO-exsA::omega,, which lacks exoenzyme S expression, was fully virulent, causing at least as much pathology as PAO1. The expression of several P. aeruginosa virulence factors appears to be required to establish pulmonary infection in the neonatal mouse.
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Citations
Cited by
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients
Smith, E. E., Buckley, D. G., Wu, Z., Saenphimmachak, C., Hoffman, L. R., D’Argenio, D. A., Miller, S. I., Ramsey, B. W., Speert, D. P., Moskowitz, S. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602138103 · Cited by 1,319
Köhler, T., Curty, L. K., Barja, F., van Delden, C., & Pechère, J.-C. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.21.5990-5996.2000 · Cited by 852
Contribution of Quorum Sensing to the Virulence of Pseudomonas aeruginosa in Burn Wound Infections
Rumbaugh, K. P., Griswold, J. A., Iglewski, B. H., & Hamood, A. N. (1999) · Infection and Immunity · doi:10.1128/iai.67.11.5854-5862.1999 · Cited by 408
Self-citationNatural pathogens of laboratory mice, rats, and rabbits and their effects on research
Baker, D. G. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.2.231 · Cited by 394
Visick, K. L., Foster, J., Doino, J., McFall-Ngai, M., & Ruby, E. G. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.16.4578-4586.2000 · Cited by 357
Metadata
- Authors
- Tang, H. B., DiMango, E., Bryan, R., Gambello, M., Iglewski, B. H., Goldberg, J. B., & Prince, A.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1996-01
- Volume
- 64
- Issue
- 1
- Pages
- 37-43
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2142319547
- Cited by
- 400
- References
- 0
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection. https://app.cochat.ai/papers/10.1128/iai.64.1.37-43.1996
- The paper
- Tang, H. B., DiMango, E., Bryan, R., Gambello, M., Iglewski, B. H., Goldberg, J. B., & Prince, A. (1996). Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection. Infection and Immunity. https://doi.org/10.1128/iai.64.1.37-43.1996
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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