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Chlamydia pneumoniae infection induces inflammatory changes in the aortas of rabbits
Open accessAbstract
Chlamydia pneumoniae, a common human respiratory pathogen, has been associated with atherosclerosis in several seroepidemiological studies. Moreover, its presence in lesions of vessel walls has been demonstrated by culture, immunohistochemistry, PCR, and electron microscopy. In this study, we infected intranasally with C. pneumoniae New Zealand White rabbits which had been fed a normal diet. Reinfection was given 3 weeks later. Six of the nine reinfected animals showed inflammatory changes consisting of intimal thickening or fibroid plaques resembling atherosclerosis in 2 to 4 weeks after reinfection. One rabbit had calcified lesions. Immunohistochemistry for C. pneumoniae was strongly positive in the three older affected animals. No lesions were seen in the controls. The results suggest that C. pneumoniae infection is capable of inducing inflammatory atherosclerosis-like changes in the aortas of infected rabbits.
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Patel, P., Mendall, M. A., Carrington, D., Strachan, D. P., Leatham, E., Molineaux, N., Levy, J., Blakeston, C., Seymour, C. A., Camm, A. J., et al. (1995) · BMJ · doi:10.1136/bmj.311.7007.711 · Cited by 592
Cited by
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Haraszthy, V. I., Zambon, J. J., Trevisan, M., Zeid, M., & Genco, R. J. (2000) · Journal of Periodontology · doi:10.1902/jop.2000.71.10.1554 · Cited by 1,120
Xu, X. H., Shah, P. K., Faure, E., Equils, O., Thomas, L., Fishbein, M. C., Luthringer, D., Xu, X.-P., Rajavashisth, T. B., Yano, J., et al. (2001) · Circulation · doi:10.1161/hc5001.100631 · Cited by 666
Ann Campbell, L., & Rosenfeld, M. (2011) · Thrombosis and Haemostasis · doi:10.1160/th11-06-0392 · Cited by 363
Miklossy, J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-90 · Cited by 355
SÖDERBERG‐NAUCLÉR, C. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01618.x · Cited by 349
Metadata
- Authors
- Laitinen, K., Laurila, A., Pyhälä, L., Leinonen, M., & Saikku, P.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1997-11
- Volume
- 65
- Issue
- 11
- Pages
- 4832-4835
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2119004647
- Cited by
- 233
- References
- 1
- FWCI
- 13.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Laitinen, K., Laurila, A., Pyhälä, L., Leinonen, M., & Saikku, P. (1997). Chlamydia pneumoniae infection induces inflammatory changes in the aortas of rabbits. Infection and Immunity. https://doi.org/10.1128/iai.65.11.4832-4835.1997
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