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Cited by 233

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Chlamydia pneumoniae infection induces inflammatory changes in the aortas of rabbits

Open access
Laitinen, K, Laurila, A, Pyhälä, L, Leinonen, M, Saikku, P·1997·Infection and Immunity

Abstract

Chlamydia pneumoniae, a common human respiratory pathogen, has been associated with atherosclerosis in several seroepidemiological studies. Moreover, its presence in lesions of vessel walls has been demonstrated by culture, immunohistochemistry, PCR, and electron microscopy. In this study, we infected intranasally with C. pneumoniae New Zealand White rabbits which had been fed a normal diet. Reinfection was given 3 weeks later. Six of the nine reinfected animals showed inflammatory changes consisting of intimal thickening or fibroid plaques resembling atherosclerosis in 2 to 4 weeks after reinfection. One rabbit had calcified lesions. Immunohistochemistry for C. pneumoniae was strongly positive in the three older affected animals. No lesions were seen in the controls. The results suggest that C. pneumoniae infection is capable of inducing inflammatory atherosclerosis-like changes in the aortas of infected rabbits.

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Crossref · 10.1128/iai.65.11.4832-4835.1997

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Metadata

Authors
Laitinen, K., Laurila, A., Pyhälä, L., Leinonen, M., & Saikku, P.
Venue
Infection and Immunity
Published
1997-11
Volume
65
Issue
11
Pages
4832-4835
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
OpenAlex
W2119004647
Cited by
233
References
1
FWCI
13.61
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Chlamydia pneumoniae infection induces inflammatory changes in the aortas of rabbits. https://app.cochat.ai/papers/10.1128/iai.65.11.4832-4835.1997
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Laitinen, K., Laurila, A., Pyhälä, L., Leinonen, M., & Saikku, P. (1997). Chlamydia pneumoniae infection induces inflammatory changes in the aortas of rabbits. Infection and Immunity. https://doi.org/10.1128/iai.65.11.4832-4835.1997

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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