Cited by 592Helicobacter pylori-related gastroenterology studiesCardiovascular Health and Risk FactorsAtherosclerosis and Cardiovascular Diseases

Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors

Open access
Patel, P, Mendall, M A, Carrington, D, Strachan, D P, Leatham, E, Molineaux, N, Levy, J, Blakeston, C +3 more·1995·BMJ

Abstract

Objective: To investigate the relation between seropositivity to chronic infections with Helicobacter pylori and Chlamydia pneumoniae and both coronary heart disease and cardiovascular risk factors. Objective:To investigate the relation between seropositivity to chronic infections with Helicobacter pylori and Chlamydia pneumoniae and both coronary heart disease and cardiovascular risk factors. Setting: General practices in Merton, Sutton, and Wandsworth, south London. Subjects: 388 white south London men aged 50-69. Main outcome measures: Evidence of coronary risk factors and infection with H pylori or C pneumoniae. Results: 47 men (12.1%) had electrocardiographic evidence of ischaemia or infarction. 36 (76.6%) and 18 (38.3%) were seropositive for H pylori and C pneumoniae, respectively, compared with 155 (45.5%) and 62 (18.2%) men with normal electrocardiograms. Odds ratios for abnormal electrocardiograms were 3.82 (95% confidence interval 1.60 to 9.10) and 3.06 (12.33 to 7.01) in men seropositive for H pylori and C pneumoniae, respectively, after adjustment for a range of socioeconomic indicators and risk factors for coronary heart disease. Cardiovascular risk factors that were independently associated with seropositivity to H pylori included fibrinogen concentration and total leucocyte count. Seropositivity to C pneumoniae was independently associated with raised fibrinogen and malondialdehyde concentrations. Conclusions: Both H pylori and C pneumoniae infections are associated with coronary heart disease. These relations are not explained by a wide range of confounding factors. Possible mechanisms include an increase in risk factor levels due to a low grade chronic inflammatory response.

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Crossref · 10.1136/bmj.311.7007.711

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Authors
Patel, P., Mendall, M. A., Carrington, D., Strachan, D. P., Leatham, E., Molineaux, N., Levy, J., Blakeston, C., Seymour, C. A., Camm, A. J., & Northfield, T. C.
Affiliations
St George's, University of London (GB)
Venue
BMJ
Publisher
BMJ
Published
1995-09-16
Volume
311
Issue
7007
Pages
711-714
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
OpenAlex
W1988289155
Cited by
592
References
32
Citations by year
2026: 2 · 2025: 1 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 14 · 2017: 5 · 2016: 4 · 2015: 11 · 2014: 12 · 2013: 6 · 2012: 12
FWCI
54.25
Type
journal article
Language
en
Open access
Locations
  • BMJ (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
Helicobacter pylori, Chlamydia pneumoniae, coronary artery disease, cardiovascular risk factors, seropositivity, chronic infection, fibrinogen, malondialdehyde, white blood cell count, myocardial infarction, low-grade inflammation, men
MeSH terms
Aged, C-Reactive Protein, Chlamydia Infections, Coronary Disease, Cross-Sectional Studies, Electrocardiography, Fibrinogen, Humans, Leukocyte Count, London, Male, Middle Aged, Risk Factors, Helicobacter pylori, Helicobacter Infections, Chlamydophila pneumoniae

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