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Evaluation of New Vaccines in the Mouse and Guinea Pig Model of Tuberculosis
Open accessAbstract
The results of this study provide the first evidence that two completely separate vaccine approaches, one based on a subunit vaccine consisting of a mild adjuvant admixed with purified culture filtrate proteins and enhanced by the cytokine interleukin-2 and the second based on immunization with DNA encoding the Ag85A protein secreted by Mycobacterium tuberculosis, could both prevent the onset of caseating disease, which is the hallmark of the guinea pig aerogenic infection model. In both cases, however, the survival of vaccinated guinea pigs was shorter than that conferred by Mycobacterium bovis BCG, with observed mortality of these animals probably due to consolidation of lung tissues by lymphocytic granulomas. An additional characteristic of these approaches was that neither induced skin test reactivity to commercial tuberculin. These data thus provide optimism that development of nonliving vaccines which can generate long-lived immunity approaching that conferred by the BCG vaccine is a feasible goal.
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Citations
Cited by
Specific immune-based diagnosis of tuberculosis
Andersen, P., Munk, M., Pollock, J., & Doherty, T. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02742-2 · Cited by 924
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis
Pym, A. S., Brodin, P., Majlessi, L., Brosch, R., Demangel, C., Williams, A., Griffiths, K. E., Marchal, G., Leclerc, C., & Cole, S. T. (2003) · Nature Medicine · doi:10.1038/nm859 · Cited by 644
A multistage tuberculosis vaccine that confers efficient protection before and after exposure
Aagaard, C., Hoang, T., Dietrich, J., Cardona, P.-J., Izzo, A., Dolganov, G., Schoolnik, G. K., Cassidy, J. P., Billeskov, R., & Andersen, P. (2011) · Nature Medicine · doi:10.1038/nm.2285 · Cited by 527
Control of latentMycobacterium tuberculosis infection is dependent on CD8 T cells
van Pinxteren, L. A. H., Cassidy, J. P., Smedegaard, B. H. C., Agger, E. M., & Andersen, P. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(200012)30:12<3689::aid-immu3689>3.0.co;2-4 · Cited by 366
Olsen, A. W., van Pinxteren, L. A. H., Okkels, L. M., Rasmussen, P. B., & Andersen, P. (2001) · Infection and Immunity · doi:10.1128/iai.69.5.2773-2778.2001 · Cited by 344
Metadata
- Authors
- Baldwin, S. L., D’Souza, C., Roberts, A. D., Kelly, B. P., Frank, A. A., Lui, M. A., Ulmer, J. B., Huygen, K., McMurray, D. M., & Orme, I. M.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1998-06
- Volume
- 66
- Issue
- 6
- Pages
- 2951-2959
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2139832445
- Cited by
- 272
- References
- 0
- FWCI
- 20.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Evaluation of New Vaccines in the Mouse and Guinea Pig Model of Tuberculosis. https://app.cochat.ai/papers/10.1128/iai.66.6.2951-2959.1998
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- Baldwin, S. L., D’Souza, C., Roberts, A. D., Kelly, B. P., Frank, A. A., Lui, M. A., Ulmer, J. B., Huygen, K., McMurray, D. M., & Orme, I. M. (1998). Evaluation of New Vaccines in the Mouse and Guinea Pig Model of Tuberculosis. Infection and Immunity. https://doi.org/10.1128/iai.66.6.2951-2959.1998
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