The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Protection of Mice with a Tuberculosis Subunit Vaccine Based on a Fusion Protein of Antigen 85B and ESAT-6
Open accessAbstract
In this study, we investigated the potential of a tuberculosis subunit vaccine based on fusion proteins of the immunodominant antigens ESAT-6 and antigen 85B. When the fusion proteins were administered to mice in the adjuvant combination dimethyl dioctadecylammonium bromide-monophosphoryl lipid A, a strong dose-dependent immune response was induced to both single components as well as to the fusion proteins. The immune response induced was accompanied by high levels of protective immunity and reached the level of Mycobacterium bovis BCG-induced protection over a broad dose range. The vaccine induced efficient immunological memory, which remained stable 30 weeks postvaccination.
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Citations
Cites
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847
Cited by
The success and failure of BCG — implications for a novel tuberculosis vaccine
Andersen, P., & Doherty, T. M. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1211 · Cited by 788
Self-citationA multistage tuberculosis vaccine that confers efficient protection before and after exposure
Aagaard, C., Hoang, T., Dietrich, J., Cardona, P.-J., Izzo, A., Dolganov, G., Schoolnik, G. K., Cassidy, J. P., Billeskov, R., & Andersen, P. (2011) · Nature Medicine · doi:10.1038/nm.2285 · Cited by 527
Self-citationESAT-6 proteins: protective antigens and virulence factors?
Brodin, P., Rosenkrands, I., Andersen, P., Cole, S. T., & Brosch, R. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.09.007 · Cited by 312
Self-citationAnnulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis
Kaufmann, S. H. E., & McMichael, A. J. (2005) · Nature Medicine · doi:10.1038/nm1221 · Cited by 273
Tuberculosis Vaccines and Prevention of Infection
Hawn, T. R., Day, T. A., Scriba, T. J., Hatherill, M., Hanekom, W. A., Evans, T. G., Churchyard, G. J., Kublin, J. G., Bekker, L.-G., & Self, S. G. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00021-14 · Cited by 164
Metadata
- Authors
- Olsen, A. W., van Pinxteren, L. A. H., Okkels, L. M., Rasmussen, P. B., & Andersen, P.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2001-05
- Volume
- 69
- Issue
- 5
- Pages
- 2773-2778
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2143543601
- Cited by
- 344
- References
- 1
- FWCI
- 14.52
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Protection of Mice with a Tuberculosis Subunit Vaccine Based on a Fusion Protein of Antigen 85B and ESAT-6. https://app.cochat.ai/papers/10.1128/iai.69.5.2773-2778.2001
- The paper
- Olsen, A. W., van Pinxteren, L. A. H., Okkels, L. M., Rasmussen, P. B., & Andersen, P. (2001). Protection of Mice with a Tuberculosis Subunit Vaccine Based on a Fusion Protein of Antigen 85B and ESAT-6. Infection and Immunity. https://doi.org/10.1128/iai.69.5.2773-2778.2001
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