The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Molecular Evolution of a Pathogenicity Island from Enterohemorrhagic Escherichia coli O157:H7
Open accessAbstract
We report the complete 43,359-bp sequence of the locus of enterocyte effacement (LEE) from EDL933, an enterohemorrhagic Escherichia coli O157:H7 serovar originally isolated from contaminated hamburger implicated in an outbreak of hemorrhagic colitis. The locus was isolated from the EDL933 chromosome with a homologous-recombination-driven targeting vector. Recent completion of the LEE sequence from enteropathogenic E. coli (EPEC) E2348/69 afforded the opportunity for a comparative analysis of the entire pathogenicity island. We have identified a total of 54 open reading frames in the EDL933 LEE. Of these, 13 fall within a putative P4 family prophage designated 933L. The prophage is not present in E2348/69 but is found in a closely related EPEC O55:H7 serovar and other O157:H7 isolates. The remaining 41 genes are shared by the two complete LEEs, and we describe the nature and extent of variation among the two strains for each gene. The rate of divergence is heterogeneous along the locus. Most genes show greater than 95% identity between the two strains, but other genes vary more than expected for clonal divergence among E. coli strains. Several of these highly divergent genes encode proteins that are known to be involved in interactions with the host cell. This pattern suggests recombinational divergence coupled with natural selection and has implications for our understanding of the interaction of both pathogens with their host, for the emergence of O157:H7, and for the evolutionary history of pathogens in general.
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Cites
The Complete Genome Sequence of Escherichia coli K-12
Blattner, F. R., Plunkett, G., Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., et al. (1997) · Science · doi:10.1126/science.277.5331.1453 · Cited by 7,452
Self-citationSharp, P. M., & Li, W.-H. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.3.1281 · Cited by 3,992
Griffin, P. M., & Tauxe, R. V. (1991) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036079 · Cited by 1,807
A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.
McDaniel, T. K., Jarvis, K. G., Donnenberg, M. S., & Kaper, J. B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1664 · Cited by 1,245
Self-citationEnteropathogenic E. coli (EPEC) Transfers Its Receptor for Intimate Adherence into Mammalian Cells
Kenny, B., DeVinney, R., Stein, M., Reinscheid, D. J., Frey, E. A., & Finlay, B. B. (1997) · Cell · doi:10.1016/s0092-8674(00)80437-7 · Cited by 1,174
Jerse, A. E., Yu, J., Tall, B. D., & Kaper, J. B. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.20.7839 · Cited by 1,124
Self-citationKnutton, S., Baldwin, T., Williams, P. H., & McNeish, A. S. (1989) · Infection and Immunity · doi:10.1128/iai.57.4.1290-1298.1989 · Cited by 875
Moon, H. W., Whipp, S. C., Argenzio, R. A., Levine, M. M., & Giannella, R. A. (1983) · Infection and Immunity · doi:10.1128/iai.41.3.1340-1351.1983 · Cited by 846
Elliott, S. J., Wainwright, L. A., McDaniel, T. K., Jarvis, K. G., Deng, Y., Lai, L., McNamara, B. P., Donnenberg, M. S., & Kaper, J. B. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00783.x · Cited by 635
Self-citationJarvis, K. G., Girón, J. A., Jerse, A. E., McDaniel, T. K., Donnenberg, M. S., & Kaper, J. B. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7996 · Cited by 626
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Cited by
Genome sequence of enterohaemorrhagic Escherichia coli O157:H7
Perna, N. T., Plunkett, G., Burland, V., Mau, B., Glasner, J. D., Rose, D. J., Mayhew, G. F., Evans, P. S., Gregor, J., Kirkpatrick, H. A., et al. (2001) · Nature · doi:10.1038/35054089 · Cited by 2,055
Self-citationPathogenicity Islands and the Evolution of Microbes
Hacker, J., & Kaper, J. B. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.641 · Cited by 1,303
Self-citationPathogenicity Islands in BacterialPathogenesis
Schmidt, H., & Hensel, M. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.1.14-56.2004 · Cited by 776
Horizontal gene transfer and the origin of species: lessons from bacteria
de la Cruz, F., & Davies, J. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01703-0 · Cited by 567
Search and Discovery Strategies for Biotechnology: the Paradigm Shift
Bull, A. T., Ward, A. C., & Goodfellow, M. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.3.573-606.2000 · Cited by 477
Metadata
- Authors
- Perna, N. T., Mayhew, G. F., Pósfai, G., Elliott, S., Donnenberg, M. S., Kaper, J. B., & Blattner, F. R.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1998-08
- Volume
- 66
- Issue
- 8
- Pages
- 3810-3817
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2127912613
- Cited by
- 419
- References
- 36
- FWCI
- 21.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Molecular Evolution of a Pathogenicity Island from Enterohemorrhagic Escherichia coli O157:H7. https://app.cochat.ai/papers/10.1128/iai.66.8.3810-3817.1998
- The paper
- Perna, N. T., Mayhew, G. F., Pósfai, G., Elliott, S., Donnenberg, M. S., Kaper, J. B., & Blattner, F. R. (1998). Molecular Evolution of a Pathogenicity Island from Enterohemorrhagic Escherichia coli O157:H7. Infection and Immunity. https://doi.org/10.1128/iai.66.8.3810-3817.1998
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
