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A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells.
Open accessAbstract
The ability of enteropathogenic Escherichia coli (EPEC) to form attaching and effacing intestinal lesions is a major characteristic of EPEC pathogenesis. Using TnphoA mutagenesis we have identified a chromosomal gene (eae, for E. coli attaching and effacing) that is necessary for this activity. A DNA probe derived from this gene hybridizes to 100% of E. coli of EPEC serogroups that demonstrate attaching and effacing activity on tissue culture cells as well as other pathogenic E. coli that produce attaching and effacing intestinal lesions, such as RDEC-1 (an EPEC of weanling rabbits) and enterohemorrhagic E. coli. The predicted amino acid sequence derived from the nucleotide sequence of eae shows significant homology to that of the invasin of Yersinia pseudotuberculosis.
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Cited by
Kaper, J. B., Nataro, J. P., & Mobley, H. L. T. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro818 · Cited by 5,583
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Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion
Sears, C. L., & Kaper, J. B. (1996) · Microbiological Reviews · doi:10.1128/mmbr.60.1.167-215.1996 · Cited by 508
Self-citationBoudeau, J., Glasser, A.-L., Masseret, E., Joly, B., & Darfeuille-Michaud, A. (1999) · Infection and Immunity · doi:10.1128/iai.67.9.4499-4509.1999 · Cited by 448
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Metadata
- Authors
- Jerse, A. E., Yu, J., Tall, B. D., & Kaper, J. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-10
- Volume
- 87
- Issue
- 20
- Pages
- 7839-7843
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2061060437
- Cited by
- 1,124
- References
- 0
- FWCI
- 20.97
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells. https://app.cochat.ai/papers/10.1073/pnas.87.20.7839
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- Jerse, A. E., Yu, J., Tall, B. D., & Kaper, J. B. (1990). A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.20.7839
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