Cited by 408Gut microbiota and healthT-cell and B-cell ImmunologyImmune Response and Inflammation

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Segmented Filamentous Bacteria Are Potent Stimuli of a Physiologically Normal State of the Murine Gut Mucosal Immune System

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Talham, Gwen L., Jiang, Han-Qing, Bos, Nicolaas A., Cebra, John J.·1999·Infection and Immunity

DOI 10.1128/iai.67.4.1992-2000.1999PMC PMC96557

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Abstract

Segmented filamentous bacteria (SFB) are autochthonous bacteria inhabiting the intestinal tracts of many species, including humans. We studied the effect of SFB on the mucosal immune system by monoassociating formerly germfree C3H/HeN mice with SFB. At various time points during 190 days of colonization, fragment cultures of small intestine and Peyer's patches (PP) were analyzed for total immunoglobulin A (IgA) and SFB-specific IgA production. Also, phenotypic changes indicating germinal center reactions (GCRs) and the activation of CD4(+) T cells in PP were determined by using fluorescence-activated cell sorter analyses. A second group of SFB-monoassociated mice was colonized with a gram-negative commensal, Morganella morganii, to determine if the mucosal immune system was again stimulated and to evaluate the effect of prior colonization with SFB on the ability of M. morganii to translocate to the spleen and mesenteric lymph nodes. We found that SFB stimulated GCRs in PP from day 6 after monoassociation, that GCRs only gradually waned over the entire length of colonization, that natural IgA production was increased to levels 24 to 63% of that of conventionally reared mice, and that SFB-specific IgA was produced but accounted for less than 1.4% of total IgA. Also, the proportion of CD4(+), CD45RBlow T cells, indicative of activated cells, gradually increased in the PP to the level found in conventionally reared mice. Secondary colonization with M. morganii was able to stimulate GCRs anew, leading to a specific IgA antibody response. Previous stimulation of mucosal immunity by SFB did not prevent the translocation of M. morganii in the double-colonized mice. Our findings generally indicate that SFB are one of the single most potent microbial stimuli of the gut mucosal immune system.

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Authors: Talham, G. L., Jiang, H.-Q., Bos, N. A., & Cebra, J. J.
Affiliations: University of Pennsylvania (US)
University of Groningen (NL)
ORCID: Bos, Nicolaas A.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 1999-04
Volume: 67
Issue: 4
Pages: 1992-2000
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.67.4.1992-2000.1999
PMC: PMC96557
OpenAlex: W2106689062
Cited by: 408
References: 23
Citations by year: 2026: 8 · 2025: 16 · 2024: 14 · 2023: 16 · 2022: 15 · 2021: 22 · 2020: 21 · 2019: 13 · 2018: 17 · 2017: 12 · 2016: 24 · 2015: 22 · 2014: 30 · 2013: 29 · 2012: 25
FWCI: 1.72
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders: National Institutes of Health (5r01ai035936-04)
National Institute of Allergy and Infectious Diseases (AI37108, R37AI037108, R01AI037108, AI-35936)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: segmented filamentous bacteria, gut mucosal immunity, immunoglobulin A, Peyer's patches, germinal center reaction, CD4+ T cell activation, Morganella morganii, commensal bacteria, bacterial translocation, germ-free mice, secondary colonization, small intestine
MeSH terms: Animals, Clostridium, Enterobacteriaceae, Female, Intestinal Mucosa, Lymph Nodes, Mesentery, Mice, Inbred BALB C, Mice, Inbred C3H, Spleen, Germinal Center, Mice

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Segmented Filamentous Bacteria Are Potent Stimuli of a Physiologically Normal State of the Murine Gut Mucosal Immune System

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