The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Host-Pathogen Interactions: Redefining the Basic Concepts of Virulence and Pathogenicity
Open accessAbstract
While preparing to teach the Microbial Pathogenesis graduate course at our institution, we found ourselves struggling to find basic definitions of virulence and pathogenicity that incorporated the contributions of both the host and the pathogen. The generally used definition of a pathogen as a microbe that causes disease in a host (Table 1) seemed inadequate, because some microbes do not cause clinically evident disease in all hosts. As we investigated the origins of the modern concepts of microbial pathogenesis, we found that while the importance of a host’s susceptibility for a microbe’s virulence was often recognized, the existing definitions did not account for the contributions of both pathogen and host. Historical definitions of pathogens were based on their ability to cause disease as an invariant trait. An integrated view of microbial pathogenesis accounting for the contributions of both host and pathogen has not been developed. In this article, we review historical concepts of microbial pathogenicity and virulence, propose new definitions, and suggest a classification system for microbial pathogens based on their ability to cause damage as a function of the host’s immune response.
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Citations
Cites
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Cited by
Disease Tolerance as a Defense Strategy
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The Genus Aeromonas : Taxonomy, Pathogenicity, and Infection
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Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
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Virulence evolution and the trade‐off hypothesis: history, current state of affairs and the future
ALIZON, S., HURFORD, A., MIDEO, N., & VAN BAALEN, M. (2009) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2008.01658.x · Cited by 932
Metadata
- Authors
- Casadevall, A., & Pirofski, L.-A.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1999-08
- Volume
- 67
- Issue
- 8
- Pages
- 3703-3713
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2099198339
- Cited by
- 769
- References
- 22
- FWCI
- 10.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Casadevall, A., & Pirofski, L.-A. (1999). Host-Pathogen Interactions: Redefining the Basic Concepts of Virulence and Pathogenicity. Infection and Immunity. https://doi.org/10.1128/iai.67.8.3703-3713.1999
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
