The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Iha: a Novel Escherichia coli O157:H7 Adherence-Conferring Molecule Encoded on a Recently Acquired Chromosomal Island of Conserved Structure
Open accessAbstract
The mechanisms used by Shiga toxin (Stx)-producing Escherichia coli to adhere to epithelial cells are incompletely understood. Two cosmids from an E. coli O157:H7 DNA library contain an adherence-conferring chromosomal gene encoding a protein similar to iron-regulated gene A (IrgA) of Vibrio cholerae (M. B. Goldberg, S. A. Boyko, J. R. Butterton, J. A. Stoebner, S. M. Payne, and S. B. Calderwood, Mol. Microbiol. 6:2407–2418, 1992). We have termed the product of this gene the IrgA homologue adhesin (Iha), which is encoded by iha . Iha is 67 kDa in E. coli O157:H7 and 78 kDa in laboratory E. coli and is structurally unlike other known adhesins. DNA adjacent to iha contains tellurite resistance loci and is conserved in structure in distantly related pathogenic E. coli , but it is absent from nontoxigenic E. coli O55:H7, sorbitol-fermenting Stx-producing E. coli O157:H−, and laboratory E. coli . We have termed this region the tellurite resistance- and adherence-conferring island. We conclude that Iha is a novel bacterial adherence-conferring protein and is contained within an E. coli chromosomal island of conserved structure. Pathogenic E. coli O157:H7 has only recently acquired this island.
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Self-citation
Metadata
- Authors
- Tarr, P. I., Bilge, S. S., Vary, J. C., Jelacic, S., Habeeb, R. L., Ward, T. R., Baylor, M. R., & Besser, T. E.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2000-03
- Volume
- 68
- Issue
- 3
- Pages
- 1400-1407
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2159153498
- Cited by
- 357
- References
- 33
- FWCI
- 14.41
- Type
- journal article
- Language
- en
- Open access
- green
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- Tarr, P. I., Bilge, S. S., Vary, J. C., Jelacic, S., Habeeb, R. L., Ward, T. R., Baylor, M. R., & Besser, T. E. (2000). Iha: a Novel Escherichia coli O157:H7 Adherence-Conferring Molecule Encoded on a Recently Acquired Chromosomal Island of Conserved Structure. Infection and Immunity. https://doi.org/10.1128/iai.68.3.1400-1407.2000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
