Influence of the Bcg Locus on Natural Resistance to Primary Infection with the Facultative Intracellular Bacterium Francisella tularensis in Mice
Open accessAbstract
The implication of the Bcg locus in the control of natural resistance to infection with a live vaccine strain (LVS) of the intracellular pathogen Francisella tularensis was studied. Analysis of phenotypic expression of natural resistance and susceptibility was performed using mouse strains congenic at the Bcg locus. Comparison of the kinetics of bacterial colonization of spleen showed that B10.A.Bcg(r) mice were extremely susceptible during early phases of primary sublethal infection, while their congenic C57BL/10N [Bcg(s)] counterparts could be classified as resistant to F. tularensis LVS infection according to the 2-log-lower bacterial CFU within the tissue as long as 5 days after infection. Different phenotypes of Bcg congenic mice were associated with differential expression of the cytokines tumor necrosis factor alpha, interleukin-10, and gamma interferon and production of reactive oxygen intermediates. These results strongly suggest that the Bcg locus, which is close or identical to the Nramp1 gene, controls natural resistance to infection by F. tularensis and that its effect is the opposite of that observed for other Bcg-controlled pathogens.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Slc11a1 coding rather than regulatory region variation is relevant to a broader spectrum of intracellular infectious agents including Francisella tularensis and S. Typhimurium.
“coding rather than in the regulatory region of Slc11a1, which is relevant to a broader spectrum of intracellular infectious agents also including Francisella tularensis and S. Typhimurium (Govoni et al., 1996;Kovarova et al., 2000;Vidal et al., 1995).”
From Iron in infection and immunity (2020) · cites this paper as Kovarova et al., 2000
In both humans and mice, NRAMP1 function affects the balance between proinflammatory mediators such as TNF and IFN-γ and antiinflammatory mediators such as IL-10 towards adequate production of the former.
“In both humans and mice, the function of NRAMP1 affects the balance between proinflammatory mediators such as TNF and IFN-γ and antiinflammatory ones such as IL-10 towards adequate production of the former (Awomoyi et al., 2002;Fritsche et al., 2003Fritsche et al., , 2008;;Kovarova et al., 2000).”
From Iron in infection and immunity (2020) · cites this paper as Kovarova et al., 2000
Cites
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061 · see citing works
The Instructive Role of Innate Immunity in the Acquired Immune Response
Fearon, D. T., & Locksley, R. M. (1996) · Science · doi:10.1126/science.272.5258.50 · Cited by 1,718 · see citing works
Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg
Vidal, S. M., Malo, D., Vogan, K., Skamene, E., & Gros, P. (1993) · Cell · doi:10.1016/0092-8674(93)90135-d · Cited by 1,104 · see citing works
Vidal, S., Tremblay, M. L., Govoni, G., Gauthier, S., Sebastiani, G., Malo, D., Skamene, E., Olivier, M., Jothy, S., & Gros, P. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.3.655 · Cited by 603 · see citing works
Nramp defines a family of membrane proteins.
Cellier, M. F., Privé, G. G., Belouchi, A., Kwan, T., Rodrigues, V., Chia, W., & Gros, P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10089 · Cited by 349 · see citing works
Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice.
Gros, P., Skamene, E., & Forget, A. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.127.6.2417 · Cited by 343 · see citing works
Unanue, E. R. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb00988.x · Cited by 263 · see citing works
Malo, D., Vogan, K. J., Vidal, S. M., Hu, J., Cellier, M. F., Schurr, E., Fuks, A., Bumstead, N., Morgan, K. W., & Gros, P. (1994) · Genomics · doi:10.1006/geno.1994.1458 · Cited by 259 · see citing works
Live vaccine strain of Francisella tularensis: infection and immunity in mice
Fortier, A. H., Slayter, M. V., Ziemba, R., Meltzer, M. S., & Nacy, C. A. (1991) · Infection and Immunity · doi:10.1128/iai.59.9.2922-2928.1991 · Cited by 257 · see citing works
Women Fight Uphill Battle for Equity
Kinoshita, J. (1996) · Science · doi:10.1126/science.274.5284.50 · Cited by 213 · see citing works
Hackam, D. J., Rotstein, O. D., Zhang, W.-J., Gruenheid, S., Gros, P., & Grinstein, S. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.351 · Cited by 202 · see citing works
Fortier, A. H., Polsinelli, T., Green, S. J., et al. (1992) · Infection and Immunity · doi:10.1128/iai.60.3.817-825.1992 · Cited by 189 · see citing works
Fortier, A. H., Leiby, D. A., Narayanan, R. B., Asafo‐Adjei, E., Crawford, R. M., Nacy, C. A., & Meltzer, M. S. (1995) · Infection and Immunity · doi:10.1128/iai.63.4.1478-1483.1995 · Cited by 172 · see citing works
Govoni, G., Vidal, S., Gauthier, S., Skamene, E., Malo, D., & Gros, P. (1996) · Infection and Immunity · doi:10.1128/iai.64.8.2923-2929.1996 · Cited by 167 · see citing works
Localisation of Nramp1 in macrophages: Modulation with activation and infection
Searle, S., Bright, N. A., Roach, T. I. A., Atkinson, P. G. P., Barton, C. H., Meloen, R. H., & Blackwell, J. M. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.19.2855 · Cited by 158 · see citing works
Forget, A., Skamene, E., Gros, P., Miailhe, A.-C., & Turcotte, R. (1981) · Infection and Immunity · doi:10.1128/iai.32.1.42-47.1981 · Cited by 116 · see citing works
Metal ion homeostasis and intracellular parasitism
Agranoff, D. D., & Krishna, S. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00790.x · Cited by 110 · see citing works
Life and death of an intracellular pathogen: Francisella tularensis and the macrophage.
Ah, F., Green, S. J., Polsinelli, T., et al. (1994) · PubMed · Cited by 106 · see citing works
Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg)
Blackwell, J. M., & Searle, S. (1999) · Immunology Letters · doi:10.1016/s0165-2478(98)00127-8 · Cited by 102 · see citing works
Blackwell, J. M., Barton, C. H., White, J. K., Roach, T. I. A., Shaw, M., Whitehead, S. H., Mock, B. A., Searle, S., Williams, H. P., & Baker, A.-M. (1994) · Immunology Letters · doi:10.1016/0165-2478(94)00161-8 · Cited by 98 · see citing works
Conlan, J. W., Sjöstedt, A. B., & North, R. J. (1994) · Infection and Immunity · doi:10.1128/iai.62.12.5603-5607.1994 · Cited by 88 · see citing works
Anthony, L. S. D., & Kongshavn, P. A. L. (1987) · Microbial Pathogenesis · doi:10.1016/0882-4010(87)90110-0 · Cited by 78 · see citing works
Culkin, S. J., Rhinehart-Jones, T. R., & Elkins, K. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.7.3277 · Cited by 75 · see citing works
ATKINSON, & Barton (1999) · Immunology · doi:10.1046/j.1365-2567.1999.00672.x · Cited by 74 · see citing works
Genetic regulation of macrophage priming/activation: the Lsh gene story
Blackwell, J. M., Roach, T. I. A., Atkinson, S. E., Ajioka, J. W., Barton, C. H., & Shaw, M. (1991) · Immunology Letters · doi:10.1016/0165-2478(91)90032-6 · Cited by 74 · see citing works
Soo, S.-S., Villarreal‐Ramos, B., Khan, C. M. A., Hormaeche, C. E., & Blackwell, J. M. (1998) · Infection and Immunity · doi:10.1128/iai.66.5.1910-1917.1998 · Cited by 68 · see citing works
Cytokine expression in the liver during the early phase of murine tularemia
Golovliov, I. R., Sandström, G., Ericsson, M., et al. (1995) · Infection and Immunity · doi:10.1128/iai.63.2.534-538.1995 · Cited by 49 · see citing works
Denis, M., Forget, A., Pelletier, M., et al. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.7.2395 · Cited by 36 · see citing works
The immune response againstFrancisella tularensislive vaccine strain in Lpsnand Lpsdmice
Macela, A., Stulík, J., Hernychová, L., et al. (1996) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1996.tb00243.x · Cited by 35 · see citing works
Self-citationTärnvik, A., Ericsson, M., Golovliov, I. R., Sandström, G., & Sjöstedt, A. B. (1996) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1996.tb00242.x · Cited by 33 · see citing works
Influence of genetic background on host resistance to experimental murine tularemia
Anthony, L. S. D., Skamene, E., & Kongshavn, P. A. L. (1988) · Infection and Immunity · doi:10.1128/iai.56.8.2089-2093.1988 · Cited by 27 · see citing works
Francisella tularensis: Host—parasite interaction
Sjöstedt, A. B., Tärnvik, A., & Sandström, G. (1996) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1996.tb00233.x · Cited by 25 · see citing works
Kovářová, H., Radzioch, D., Hajdúch, M., Šírová, M., Bláha, V., Macela, A., Stulík, J., & Hernychová, L. (1998) · Electrophoresis · doi:10.1002/elps.1150190820 · Cited by 17 · see citing works
Self-citationFrancisella tularensis: Host-parasite interaction
Sjöstedt, A. B. (1996) · FEMS Immunology & Medical Microbiology · doi:10.1016/0928-8244(95)00100-x · Cited by 14 · see citing works
Hernychová, L., Kovarova, H., Macela, A., et al. (1997) · Immunology Letters · doi:10.1016/s0165-2478(97)00063-1 · Cited by 11 · see citing works
Self-citationKovarova, H., Marcela, A.-H., & Stulík, J. (1992) · PubMed · Cited by 6 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Iron in infection and immunity
Nairz, M., & Weiss, G. (2020) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2020.100864 · Cited by 359 · see citing works
Iron in immune cell function and host defense
Haschka, D., Hoffmann, A., & Weiss, G. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.12.005 · Cited by 188 · see citing works
Nramp1 and NrampB Contribute to Resistance against Francisella in Dictyostelium
Brenz, Y., Ohnezeit, D., Winther-Larsen, H. C., & Hagedorn, M. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00282 · Cited by 19 · see citing works
- Authors
- Kovářová, H., Hernychová, L., Hajdúch, M., Šírová, M., & Macela, A.
- Affiliations
- <!--label omitted: 1-->Institute for Immunology and Radiobiology, Purkyně Military Medical Academy, 500 01 Hradec Králové,1
- <!--label omitted: 2-->Department of Pediatrics, Faculty of Medicine, Palacky University and Faculty Hospital, 775 15 Olomouc,2 and
- <!--label omitted: 3-->Institute of Microbiology, Academy of Science of the Czech Republic, 142 20 Prague,3 Czech Republic
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2000-03
- Volume
- 68
- Issue
- 3
- Pages
- 1480-1484
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC97304
- OpenAlex
- W2141910949
- Cited by
- 17
- References
- 36
- Citations by year
- 2021: 1 · 2020: 2 · 2017: 3 · 2016: 1
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacillus and Francisella bacterial research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- natural resistance to infection, Francisella tularensis, live vaccine strain, facultative intracellular bacteria, NRAMP1, congenic mice, TNF-α, IL-10, interferon-gamma, reactive oxygen species, host genetic resistance
- MeSH terms
- Natural Resistance-associated Macrophage Protein 1, Animals, Carrier Proteins, Cells, Cultured, Chromosome Mapping, Female, Immunity, Innate, Membrane Proteins, Mice, Inbred C57BL, Nitrites, Spleen, Tularemia, Cytokines, Reactive Oxygen Species, Cation Transport Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
