The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
TonB-Dependent Systems of Uropathogenic Escherichia coli: Aerobactin and Heme Transport and TonB Are Required for Virulence in the Mouse
Open accessAbstract
The uropathogenic Escherichia coli strain CFT073 has multiple iron acquisition systems, including heme and siderophore transporters. A tonB mutant derivative of CFT073 failed to use heme as an iron source or to utilize the siderophores enterobactin and aerobactin, indicating that transport of these compounds in CFT073 is TonB dependent. The TonB−derivative showed reduced virulence in a mouse model of urinary tract infection. Virulence was restored when the tonB gene was introduced on a plasmid. To determine the importance of the individual TonB-dependent iron transport systems during urinary tract infections, mutants defective in each of the CFT073 high-affinity iron transport systems were constructed and tested in the mouse model. Mouse virulence assays indicated that mutants defective in a single iron transport system were able to infect the kidney when inoculated as a pure culture but were unable to efficiently compete with the wild-type strain in mixed infections. These results indicate a role for TonB-dependent systems in the virulence of uropathogenic E. coli strains.
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Nucleotide Biosynthesis Is Critical for Growth of Bacteria in Human Blood
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Metadata
- Authors
- Torres, A. G., Redford, P., Welch, R. A., & Payne, S. M.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2001-10
- Volume
- 69
- Issue
- 10
- Pages
- 6179-6185
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2108503897
- Cited by
- 287
- References
- 55
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Torres, A. G., Redford, P., Welch, R. A., & Payne, S. M. (2001). TonB-Dependent Systems of Uropathogenic Escherichia coli: Aerobactin and Heme Transport and TonB Are Required for Virulence in the Mouse. Infection and Immunity. https://doi.org/10.1128/iai.69.10.6179-6185.2001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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