The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Iron, copper, zinc, and manganese transport and regulation in pathogenic Enterobacteria: correlations between strains, site of infection and the relative importance of the different metal transport systems for virulence
Open accessAbstract
For all microorganisms, acquisition of metal ions is essential for survival in the environment or in their infected host. Metal ions are required in many biological processes as components of metalloproteins and serve as cofactors or structural elements for enzymes. However, it is critical for bacteria to ensure that metal uptake and availability is in accordance with physiological needs, as an imbalance in bacterial metal homeostasis is deleterious. Indeed, host defense strategies against infection either consist of metal starvation by sequestration or toxicity by the highly concentrated release of metals. To overcome these host strategies, bacteria employ a variety of metal uptake and export systems and finely regulate metal homeostasis by numerous transcriptional regulators, allowing them to adapt to changing environmental conditions. As a consequence, iron, zinc, manganese, and copper uptake systems significantly contribute to the virulence of many pathogenic bacteria. However, during the course of our experiments on the role of iron and manganese transporters in extraintestinal Escherichia coli (ExPEC) virulence, we observed that depending on the strain tested, the importance of tested systems in virulence may be different. This could be due to the different set of systems present in these strains, but literature also suggests that as each pathogen must adapt to the particular microenvironment of its site of infection, the role of each acquisition system in virulence can differ from a particular strain to another. In this review, we present the systems involved in metal transport by Enterobacteria and the main regulators responsible for their controlled expression. We also discuss the relative role of these systems depending on the pathogen and the tissues they infect.
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Cites
Andrews, S. C., Robinson, A. K., & Rodríguez-Quiñones, F. (2003) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(03)00055-x · Cited by 2,702 · cited 3×
“Many Enterobacteria are able to internalize exogenous siderophores, such as the fungal siderophore ferrichrome, internalized through FhuABCD (Andrews et al., 2003).”
BackgroundNutritional immunity: transition metals at the pathogen–host interface
Hood, M. I., & Skaar, E. P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2836 · Cited by 1,535
Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis
Outten, C. E., & O'Halloran, A. T. V. (2001) · Science · doi:10.1126/science.1060331 · Cited by 1,489
The Battle for Iron between Bacterial Pathogens and Their Vertebrate Hosts
Skaar, E. P. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000949 · Cited by 796
Probiotic Bacteria Reduce Salmonella Typhimurium Intestinal Colonization by Competing for Iron
Deriu, E., Liu, J. Z., Pezeshki, M., Edwards, R. A., Ochoa, R. J., Contreras, H., Libby, S. J., Fang, F. C., & Raffatellu, M. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.06.007 · Cited by 550
A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity
White, C., Lee, J., Kambe, T., Fritsche, K., & Petris, M. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.070201 · Cited by 524
The ZnuABC high‐affinity zinc uptake system and its regulator Zur in Escherichia coli
Patzer, S. I., & Hantke, K. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00883.x · Cited by 490 · cited 10×
“…to the wild-type Frontiers in Cellular and Infection Microbiology www.frontiersin.org December 2013 | Volume 3 | Article 90 | 7 strains (Table S1; Patzer and Hantke, 1998; Campoy et al., 2002; Ammendola et al., 2007; Gunasekera et al., 2009; Sabri et al., 2009; Desrosiers et al., 2010;…”
BackgroundInfluentialThe zntA gene of Escherichia coli encodes a Zn(II)-translocating P-type ATPase
Rensing, C., Mitra, B., & Rosen, B. P. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14326 · Cited by 419
Liu, J. Z., Jellbauer, S., Poe, A. J., Ton, V., Pesciaroli, M., Kehl-Fie, T. E., Restrepo, N. A., Hosking, M. P., Edwards, R. A., Battistoni, A., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.017 · Cited by 328
The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2
Fischbach, M. A., Lin, H., Zhou, L., Yu, Y., Abergel, R. J., Liu, D. R., Raymond, K. N., Wanner, B. L., Strong, R. K., Walsh, C. T., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604636103 · Cited by 319
Cited by
Borges, A., Abreu, A., Dias, C., Saavedra, M., Borges, F., & Simões, M. (2016) · Molecules · doi:10.3390/molecules21070877 · Cited by 308
Si, M., Zhao, C., Burkinshaw, B., Zhang, B., Wei, D., Wang, Y., Dong, T. G., & Shen, X. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614902114 · Cited by 245
Type VI Secretion System Transports Zn2+ to Combat Multiple Stresses and Host Immunity
Wang, T., Si, M., Song, Y., Zhu, W., Gao, F., Wang, Y., Zhang, L., Zhang, W., Wei, G., Luo, Z.-Q., et al. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1005020 · Cited by 210
Metallochaperones and metalloregulation in bacteria
Capdevila, D. A., Edmonds, K. A., & Giedroc, D. P. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160076 · Cited by 136
Manganese homeostasis and utilization in pathogenic bacteria
Juttukonda, L. J., & Skaar, E. P. (2015) · Molecular Microbiology · doi:10.1111/mmi.13034 · Cited by 121
“, 2014), the role of transition metals in Enterobacteria virulence (Porcheron et al., 2013) and the importance of Mn and Zn in nutritional immunity (Kehl-Fie and Skaar, 2010).”
Background
Metadata
- Authors
- Porcheron, G., Garénaux, A., Proulx, J., Sabri, M., & Dozois, C. M.
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 3
- Pages
- 90-90
- ISSN
- 2235-2988 (ISSN-L)
- OpenAlex
- W1969504421
- Cited by
- 366
- References
- 38
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- gold
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- Porcheron, G., Garénaux, A., Proulx, J., Sabri, M., & Dozois, C. M. (2013). Iron, copper, zinc, and manganese transport and regulation in pathogenic Enterobacteria: correlations between strains, site of infection and the relative importance of the different metal transport systems for virulence. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2013.00090
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