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Effect of SpeB and EndoS from Streptococcus pyogenes on Human Immunoglobulins
Open accessAbstract
Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity, while EndoS is highly specific for IgG.
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Cited by
Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus
Walker, M. J., Barnett, T. C., McArthur, J. D., Cole, J. N., Gillen, C. M., Henningham, A., Sriprakash, K. S., Sanderson-Smith, M. L., & Nizet, V. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00101-13 · Cited by 908
IdeS, a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G
von Pawel-Rammingen, U. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1607 · Cited by 473
Nelson, D. C., Garbe, J., & Collin, M. (2011) · bchm · doi:10.1515/bc.2011.208 · Cited by 160
Self-citationBacterial Proteases and Virulence
Frees, D., Brøndsted, L., & Ingmer, H. (2013) · Subcellular Biochemistry · doi:10.1007/978-94-007-5940-4_7 · Cited by 159
Zhang, X., Lu, C., Zhang, F., Song, Y., Cai, M., & Zhu, H. (2017) · Pathogens and Disease · doi:10.1093/femspd/ftx085 · Cited by 8
Metadata
- Authors
- Collin, M., & Olsén, A.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2001-11
- Volume
- 69
- Issue
- 11
- Pages
- 7187-7189
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2126168699
- Cited by
- 203
- References
- 0
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Collin, M., & Olsén, A. (2001). Effect of SpeB and EndoS from Streptococcus pyogenes on Human Immunoglobulins. Infection and Immunity. https://doi.org/10.1128/iai.69.11.7187-7189.2001
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