The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Deletion of Two-Component Regulatory Systems Increases the Virulence of Mycobacterium tuberculosis
Open accessAbstract
Two-component regulatory signal transduction systems are widely distributed among bacteria and enable the organisms to make coordinated changes in gene expression in response to a variety of environmental stimuli. The genome sequence of Mycobacterium tuberculosis contains 11 complete two-component systems, four isolated homologous regulators, and three isolated homologous sensors. We have constructed defined mutations in six of these genes and measured virulence in a SCID mouse model. Mice infected with four of the mutants (deletions of devR , tcrXY , trcS , and kdpDE ) died more rapidly than those infected with wild-type bacteria. The other two mutants ( narL and Rv3220c ) showed no change compared to the wild-type H37Rv strain. The most hypervirulent mutant ( devR Δ) also grew more rapidly in the acute stage of infection in immunocompetent mice and in gamma interferon-activated macrophages. These results define a novel class of genes in this pathogen whose presence slows down its multiplication in vivo or increases its susceptibility to host killing mechanisms. Thus, M. tuberculosis actively maintains a balance between its own survival and that of the host.
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Cites
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Cited by
The Enduring Hypoxic Response of Mycobacterium tuberculosis
Rustad, T. R., Harrell, M. I., Liao, R., & Sherman, D. R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001502 · Cited by 491
Tuberculosis — metabolism and respiration in the absence of growth
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Bacterial Growth and Cell Division: a Mycobacterial Perspective
Hett, E. C., & Rubin, E. J. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00028-07 · Cited by 408
Rao, V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27335 · Cited by 200
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Metadata
- Authors
- Parish, T., Smith, D. A., Kendall, S., Casali, N., Bancroft, G. J., & Stoker, N. G.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2003-03
- Volume
- 71
- Issue
- 3
- Pages
- 1134-1140
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2132473872
- Cited by
- 293
- References
- 39
- FWCI
- 10.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Parish, T., Smith, D. A., Kendall, S., Casali, N., Bancroft, G. J., & Stoker, N. G. (2003). Deletion of Two-Component Regulatory Systems Increases the Virulence of Mycobacterium tuberculosis. Infection and Immunity. https://doi.org/10.1128/iai.71.3.1134-1140.2003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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