The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Relationship between Candida albicans Virulence during Experimental Hematogenously Disseminated Infection and Endothelial Cell Damage In Vitro
Open accessAbstract
Candida albicans must penetrate the endothelial cell lining of the vasculature to invade the deep tissues during a hematogenously disseminated infection. We compared 27 C. albicans mutants with their wild-type parent for their capacity to damage endothelial cells in vitro and cause a lethal infection in mice following tail vein inoculation. Of 10 mutants with significantly impaired capacity to damage endothelial cells, all had attenuated virulence. Therefore, the endothelial cell damage assay can be used as a screen to identify some virulence factors relevant to hematogenously disseminated candidiasis.
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“We have found previously that C. albicans mutants with defects in the signal transduction pathways that govern hyphal formation have a significantly reduced capacity to invade both endothelial and oral epithelial cells in vitro [5][6][7].”
From Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells (2007) · cites this paper as [6]
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“Host cell invasion and damage are likely critical virulence attributes of C. albicans because mutants with defects in these processes in vitro are highly likely to have attenuated virulence in experimental animal models of hematogenously disseminated or oropharyngeal candidiasis [5][6][7][8].”
From Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells (2007) · cites this paper as [6]
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Cites
Nonfilamentous C. albicans Mutants Are Avirulent
Lo, H.-J., Köhler, J. R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., & Fink, G. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80358-x · Cited by 1,809
Isogenic strain construction and gene mapping in Candida albicans.
Fonzi, W. A., & Irwin, M. Y. (1993) · Genetics · doi:10.1093/genetics/134.3.717 · Cited by 1,695
Yeast-enhanced green fluorescent protein (yEGFP): a reporter of gene expression in Candida albicans
Cormack, B. P., Bertram, G., Egerton, M., Gow, N. A. R., Falkow, S., & Brown, A. J. P. (1997) · Microbiology · doi:10.1099/00221287-143-2-303 · Cited by 593
Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1.
Gale, C. A., Bendel, C. M., McClellan, M., Hauser, M., Becker, J. M., Berman, J., & Hostetter, M. K. (1998) · Science · doi:10.1126/science.279.5355.1355 · Cited by 356
Hube, B., Sanglard, D., Odds, F. C., Hess, D., Monod, M., Schäfer, W., Brown, A. J. P., & Gow, N. A. R. (1997) · Infection and Immunity · doi:10.1128/iai.65.9.3529-3538.1997 · Cited by 311
Identification and Characterization of TUP1-Regulated Genes in Candida albicans
Braun, B. R., Head, W. S., Wang, M. X., & Johnson, A. D. (2000) · Genetics · doi:10.1093/genetics/156.1.31 · Cited by 306
RIM101-Dependent and -Independent Pathways Govern pH Responses in Candida albicans
Davis, D. A., Wilson, R. B., & Mitchell, A. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.971-978.2000 · Cited by 296
Self-citationKöhler, J. R., & Fink, G. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13223 · Cited by 282
Sanglard, D., Hube, B., Monod, M., Odds, F. C., & Gow, N. A. R. (1997) · Infection and Immunity · doi:10.1128/iai.65.9.3539-3546.1997 · Cited by 282
Candida albicans RIM101 pH Response Pathway Is Required for Host-Pathogen Interactions
Davis, D. A., Edwards, J. E., Mitchell, A. P., & Ibrahim, A. S. (2000) · Infection and Immunity · doi:10.1128/iai.68.10.5953-5959.2000 · Cited by 276
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The Fungal PathogenCandida albicans
Fanning, S., & Mitchell, A. P. (2014) · ASM Press eBooks · doi:10.1128/9781555816636.ch46
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Metadata
- Authors
- Sanchez, A. A., Johnston, D. A., Myers, C., Edwards, J. E., Mitchell, A. P., & Filler, S. G.
- Affiliations
- University of California, Los Angeles (US)
- Columbia University (US)
- Corresponding author
- Filler, Scott G.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2004-01
- Volume
- 72
- Issue
- 1
- Pages
- 598-601
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC344013
- OpenAlex
- W2133054734
- Cited by
- 101
- References
- 36
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 6 · 2014: 11 · 2013: 5 · 2012: 5
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Infection and Immunity (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (P01 AI-37194, R29AI040636, R01AI019990, R01AI050931, R01-AI19990, R01 AI 50931, P01AI037194)
- National Institute of Dental and Craniofacial Research (R01DE013974, R01 DE 13974)
- National Center for Research Resources (M01RR000425, M01-RR00425)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- Candida albicans, virulence factors, endothelial injury, fungal mutants
- MeSH terms
- Animals, Candida albicans, Candidiasis, Cytotoxicity Tests, Immunologic, Endothelium, Vascular, Male, Mice, Inbred BALB C, Mutation, Umbilical Cord, Virulence, Virulence Factors, Endothelial Cells, Mice
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