The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Serum Levels of the Proinflammatory Cytokines Interleukin-1 Beta (IL-1β), IL-6, IL-8, IL-10, Tumor Necrosis Factor Alpha, and IL-12(p70) in Malian Children with Severe Plasmodium falciparum Malaria and Matched Uncomplicated Malaria or Healthy Controls
Open accessAbstract
Inflammatory cytokines play an important role in human immune responses to malarial disease. However, the role of these mediators in disease pathogenesis, and the relationship between host protection and injury remains unclear. A total of 248 cases of severe Plasmodium falciparum malaria among children aged 3 months to 14 years residing in Bandiagara, Mali, were matched to cases of uncomplicated malaria and healthy controls. Using modified World Health Organization criteria for defining severe malaria, we identified 100 cases of cerebral malaria (coma, seizure, and obtundation), 17 cases of severe anemia (hemoglobin, <5 g/dl), 18 cases combined cerebral malaria with severe anemia, and 92 cases with hyperparasitemia (asexual trophozoites, >500,000/mm 3). Significantly elevated levels (given as geometric mean concentrations in picograms/milliliter) of interleukin-6 (IL-6; 485.2 versus 54.1;P= <0.001), IL-10 (1,099.3 versus 14.1;P= <0.001), tumor necrosis factor alpha (10.1 versus 7.7;P= <0.001), and IL-12(p70) (48.9 versus 31.3;P= 0.004) in serum were found in severe cases versus healthy controls. Significantly elevated levels of IL-6 (485.2 versus 141.0;P= <0.001) and IL-10 (1,099.3 versus 133.9;P= <0.001) were seen in severe malaria cases versus uncomplicated malaria controls. Cerebral malaria was associated with significantly elevated levels of IL-6 (754.5 versus 311.4;P= <0.001) and IL-10 (1,405.6 versus 868.6;P= 0.006) compared to severe malaria cases without cerebral manifestations. Conversely, lower levels of IL-6 (199.2 versus 487.6;P= 0.03) and IL-10 (391.1 versus 1,160.9;P= 0.002) were noted in children with severe anemia compared to severe malaria cases with hemoglobin at >5 g/dl. Hyperparasitemia was associated with significantly lower levels of IL-6 (336.6 versus 602.1;P= 0.002). These results illustrate the complex relationships between inflammatory cytokines and disease in P. falciparum malaria.
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The complexities of malaria disease manifestations with a focus on asymptomatic malaria
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Distinct physiological states of Plasmodium falciparum in malaria-infected patients
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Cytokines in CAR T Cell–Associated Neurotoxicity
Gust, J., Ponce, R., Liles, W. C., Garden, G. A., & Turtle, C. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.577027 · Cited by 264
The two faces of interleukin 10 in human infectious diseases
Mege, J.-L., Meghari, S., Honstettre, A., Capo, C., & Raoult, D. (2006) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(06)70577-1 · Cited by 257
Metadata
- Authors
- Lyke, K. E., Burges, R., Cissoko, Y., Sangare, L., Dao, M., Diarra, I., Kone, A., Harley, R., Plowe, C. V., Doumbo, O. K., & Sztein, M. B.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2004-10
- Volume
- 72
- Issue
- 10
- Pages
- 5630-5637
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2146597942
- Cited by
- 434
- References
- 43
- FWCI
- 11.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Lyke, K. E., Burges, R., Cissoko, Y., Sangare, L., Dao, M., Diarra, I., Kone, A., Harley, R., Plowe, C. V., Doumbo, O. K., & Sztein, M. B. (2004). Serum Levels of the Proinflammatory Cytokines Interleukin-1 Beta (IL-1β), IL-6, IL-8, IL-10, Tumor Necrosis Factor Alpha, and IL-12(p70) in Malian Children with Severe Plasmodium falciparum Malaria and Matched Uncomplicated Malaria or Healthy Controls. Infection and Immunity. https://doi.org/10.1128/iai.72.10.5630-5637.2004
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
