In Vivo Interleukin-6 Protects Neutrophils from Apoptosis in Osteomyelitis
Open accessAbstract
Polymorphonuclear neutrophils are critical for resolution of bacterial infections. In tissues, most of the neutrophils quickly die through apoptosis. Using propidium iodide DNA staining and DNA gel electrophoresis, we found that spontaneous apoptosis of neutrophils from patients suffering osteomyelitis (n= 52) was significantly decreased in relation to control neutrophils (n= 20) (40.2% ± 25.2% versus 54.5% ± 23.5%;P< 0.03). Incubation of neutrophils from normal volunteers with sera from patients with osteomyelitis reduced apoptosis from 79.1% ± 14.8% in control sera to 62.2% ± 18.7% in osteomyelitis sera. A significant increase of serum interleukin-6 (IL-6) and IL-1α was found in osteomyelitis (IL-6, 8.8 ± 11.9 pg/ml versus 1.8 ± 1.2 pg/ml in controls [P< 0.004]; IL-1α, 3.8 ± 6.4 pg/ml versus 1.0 ± 2.2 pg/ml in controls [P< 0.02]). No differences in the levels of other cytokines, such as tumor necrosis factor alpha, were found. There was an inverse correlation between IL-6 levels and neutrophil apoptosis (r= −0.855;P< 0.007), but this was not the case for other cytokines. The antiapoptotic effect of the osteomyelitis sera was reversed with anti-IL-6 antibodies (P< 0.03) and was reproduced with recombinant human IL-6 (P< 0.001). The longer life span of neutrophils in osteomyelitis induced by IL-6 could contribute to the tissue damage that occurs in these chronic bone infections.
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Elevated IL-6 prolongs neutrophil survival by reducing apoptosis.
“elevated levels of IL-6, as either part of the host pathogen response or due to inflammageing, engenders prolonged neutrophil survival through reducing apoptosis87”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [87]
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- Authors
- Asensi, V., Valle, E., Meana, A., Fierer, J., Celada, A., Alvarez, V., Paz, J., Coto, E., Carton, J. A., Maradona, J. A., Dieguez, A., Sarasúa, J., Ocaña, M. G., & Arribas, J. M.
- Affiliations
- Infectious Diseases and Molecular Genetics UnitsDepartments of
- University of California San Diego (US)
- Institut d'Investigacions Biomèdiques de Barcelona (ES)
- Traumatology
- Plastic Surgery, Hospital Central de Asturias, Oviedo University Medical School, Oviedo
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2004-07
- Volume
- 72
- Issue
- 7
- Pages
- 3823-3828
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC427428
- OpenAlex
- W2120399781
- Cited by
- 93
- References
- 42
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 2 · 2017: 8 · 2016: 1 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 4
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- interleukin-6, neutrophil apoptosis, osteomyelitis, IL-1α, anti-apoptotic effects, serum cytokines, anti-IL-6 antibody, neutrophil lifespan, chronic bone infection, tissue damage
- MeSH terms
- Female, Humans, Inflammation, Male, Middle Aged, Neutrophils, Osteomyelitis, Interleukin-6, Cytokines, Apoptosis, Serum
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