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Bactericidal Activity of Aerobic and Anaerobic Polymorphonuclear Neutrophils
Open accessAbstract
Human polymorphonuclear neutrophils (PMN) were made anaerobic by nitrogen washout (oxygen saturation <1%, Eh < −42 mV at pH 7.0), and the ability of the cells to kill bacteria was assayed and compared to the bactericidal activity of aerobic PMN. Anaerobic PMN were able to kill Staphylococcus epidermidis, Enterococcus , viridans streptococci, Pseudomonas aeruginosa, Peptostreptococcus anaerobius, Bacteroides fragilis, Clostridium perfringens , and Peptococcus magnus normally. Organisms that were not killed normally by anaerobic PMN included Staphylococcus aureus (strains Wood 46 and 502a), Escherichia coli, Serratia marcescens, Klebsiella pneumoniae, Proteus vulgaris , and Salmonella typhimurium. These findings suggest that mechanisms other than those dependent on hydrogen peroxide may be important in the killing of some bacteria.
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Citations
Cited by
Killing activity of neutrophils is mediated through activation of proteases by K+ flux
Reeves, E. P., Lu, H., Jacobs, H. L., Messina, C. G. M., Bolsover, S., Gabella, G., Potma, E. O., Warley, A., Roes, J., & Segal, A. W. (2002) · Nature · doi:10.1038/416291a · Cited by 1,153
Parkos, C. A., Allen, R. A., Cochrane, C. G., & Jesaitis, A. J. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113128 · Cited by 455
Iron and infection: the heart of the matter
Bullen, J. J., Rogers, H. J., Spalding, P. B., & Ward, C. G. (2005) · FEMS Immunology & Medical Microbiology · doi:10.1016/j.femsim.2004.11.010 · Cited by 273
Effects of oxygen tension and pH on the respiratory burst of human neutrophils
Gabig, T., Bearman, S., & Babior, B. (1979) · Blood · doi:10.1182/blood.v53.6.1133.1133 · Cited by 190
Natural resistance, iron and infection: a challenge for clinical medicine
Bullen, J. J., Rogers, H. J., Spalding, P. B., & Ward, C. G. (2006) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46386-0 · Cited by 163
Metadata
- Authors
- Mandell, G. L.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1974-02
- Volume
- 9
- Issue
- 2
- Pages
- 337-341
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W1873563342
- Cited by
- 329
- References
- 0
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mandell, G. L. (1974). Bactericidal Activity of Aerobic and Anaerobic Polymorphonuclear Neutrophils. Infection and Immunity. https://doi.org/10.1128/iai.9.2.337-341.1974
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