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Cited by 190Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressBioactive Compounds and Antitumor Agents

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Effects of oxygen tension and pH on the respiratory burst of human neutrophils

Open access
Gabig, TG, Bearman, SI, Babior, BM·1979·Blood
DOI 10.1182/blood.v53.6.1133.1133
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Abstract

The respiratory burst of human neutrophils was measured under conditions of hypoxia and low pH. O2 -- production by neutrophils activated with opsonized zymosan fell slowly as the oxygen concentration declined to 1%, then dropped more sharply, reaching negligible levels at oxygen concentrations less than 0.25%. Production was half maximal at an oxygen concentration of 0.35% (equivalent to approximately 10-microM dissolved oxygen). O2- production by the cell- free O2- -forming system prepared from zymosan-activated neutrophils showed a similar dependence on oxygen concentration. A drop in pH caused decreases in both oxygen consumption and O2-- production by zymosan-treated neutrophils, values at PH 6.0 being 10%--20% of those observed at pH 7.5. Experiments with the cell-free O2-- -forming system suggested that this decline in respiratory burst activity at low pH was due to inefficient activation of the O2-- -forming enzyme under acidic conditions.

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  • The PMN oxidative burst is not hindered by even relatively low O2 (as low as 4.5% O2), so ROS can be generated in the relatively low O2 environments of inflamed intestinal mucosa.

    “Notably, the PMN oxidative burst is not hindered by even relatively low O2 (as low as 4.5% O2)8, which is important, since it means that ROS can be generated in the relatively low O2 environments of inflamed intestinal mucosa3.”

    From Hypoxia: an alarm signal during intestinal inflammation (2010) · cites this paper as [8]

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Metadata

Authors
Gabig, T., Bearman, S., & Babior, B.
Affiliations
Tufts Medical Center (US)
Venue
Blood
Publisher
American Society of Hematology
Published
1979-06-01
Volume
53
Issue
6
Pages
1133-1139
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood.v53.6.1133.1133
OpenAlex
W1501589213
Cited by
190
References
13
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 3 · 2012: 7
FWCI
1.14
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Keywords
respiratory burst, neutrophils, hypoxia, oxygen partial pressure, low pH, superoxide production, zymosan, opsonized zymosan, NADPH oxidase, oxygen consumption, enzyme activation
MeSH terms
Hypoxia, Humans, Hydrogen-Ion Concentration, Neutrophils, Oxygen, Oxygen Consumption, Phagocytosis

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